ABCG2/CD338 Antibody (S02-5C2)

Name: ABCG2/CD338 Antibody (S02-5C2)
Brand: Novus Biologicals
SKU: NBP3-19837
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19837

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-5C2 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human ABCG2/CD338 (Uniprot # Q9UNQ0)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

72 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ABCG2/CD338 Antibody (S02-5C2)

Western Blot: ABCG2/CD338 Antibody (S02-5C2) [NBP3-19837]

Western Blot: ABCG2/CD338 Antibody (S02-5C2) [NBP3-19837] - Western blot detection of ABCG2/CD338 in HepG2, U251, HL-60 using NBP3-19837 (1:1000 diluted)

Applications for ABCG2/CD338 Antibody (S02-5C2)

Application

Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ABCG2

Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) p-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). Tumor cells can be intrinsically resistant to drugs or they can acquire resistance to structurally and functionally unrelated drugs on drug exposure. This phenomenon is known as multidrug resistance (MDR). In human tumor cells, several transporter proteins can be involved in MDR. These proteins, MDR1 P-gp (ABCB1), MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3), and BCRP (ABCG2), belong to the ABC transporter family. They act as efflux pumps, which result in decreased intracellular concentrations of cytotoxic drugs. BCRP is a recently discovered half-transporter that probably acts as a homo- or heterodimer in transporting cytotoxic agents. The transporter molecule is capable of transporting several anticancer drugs but has thus far been found mainly in MX-resistant cell lines.

Long Name

ATP-binding Cassette Transporter G2

Alternate Names

ABCP, BCRP, CD338, MXR

Gene Symbol

ABCG2

Additional ABCG2 Products

Product Documents for ABCG2/CD338 Antibody (S02-5C2)

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Product Specific Notices for ABCG2/CD338 Antibody (S02-5C2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.