Antibiotic-Antimycotic (100X)

Contains 10,000 units/mL penicillin (base), 10,000 µg/mL streptomycin (base) and 25 µg/mL amphotericin B in 0.85% saline, utilizing penicillin G sodium salt, streptomycin sulfate and amphotericin B as Fungizone© Antimycotic. Antibiotic-Antimycotic is stable for 3 days at 37 °C.

Antibiotic-Antimycotic Solution contains penicillin, streptomycin, and Amphotericin B. Penicillin is a beta-lactam antibiotic derived from Penicillium fungi. It interferes with the final stage of bacterial cell wall synthesis, the cross-linking of different peptidoglycan strands. Amphotericin B is a polyene antifungal agent originally extracted from Streptomyces. Streptomycin is an aminoglycoside antibiotic produced by Streptomyces. It binds to the 30S subunit of the bacterial 70S ribosome and blocks the initiation complex of protein synthesis. It interferes with the permeability of cell membranes of sensitive fungi and yeasts. Amphotericin B forms a complex with ergosterol and causes leakage of low molecular weight substances from the cells.