Asenapine maleate

Tocris Bioscience | Catalog # 3737

Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
Tocris Bioscience

Key Product Details

Description

Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
View all Non-selective 5-HT Receptor Antagonists »

Product Description

Asenapine maleate is a novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

Product Specifications for Asenapine maleate

Molecular Weight

401.84

Formula

C17H16ClNO.C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

CAS Number

85650-56-2

PubChem ID

73416848

InChI Key

QGBIWSABMNWWNB-FGYPTBLJSA-N

SMILES

CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.18 100
Ethanol 20.09 50

Preparing Stock Solutions for Asenapine maleate

The following data is based on the product molecular weight 401.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.50 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for Asenapine maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Asenapine maleate

For research use only

Citations for Asenapine maleate

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