Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi
values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A
receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.
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All Tocris products are intended for laboratory research use only.
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
Shahid et al.
Meltzer et al.
Nat.Rev.Drug Discov., 2009;8:843
Asenapine effects in animal models of psychosis and cognitive function.
Marston et al.
The citations listed below are publications that use Tocris products. Selected citations for Asenapine maleate include:
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