Asenapine maleate

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3737/10
3737/50
Asenapine maleate | CAS No. 85650-56-2 | Non-selective 5-HT Receptor Antagonists
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Description: Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent

Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

Technical Data

M.Wt:
401.84
Formula:
C17H16ClNO.C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
85650-56-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
    Shahid et al.
    J.Psychopharmacol., 2009;23:65
  2. Asenapine.
    Meltzer et al.
    Nat.Rev.Drug Discov., 2009;8:843
  3. Asenapine effects in animal models of psychosis and cognitive function.
    Marston et al.
    Psychopharmacol., 2009;206:699

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Citation for Asenapine maleate

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