Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Biological ActivityPotent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and further development of potent TBK1 inhibitors.
Richters et al.
ACS Chem Biol., 2015;10:289
Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.
Robke et al.
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