Autophinib

Key Product Details

Product Description

Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC₅₀ = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC₅₀ values = 40 and 90 nM, respectively).

Product Specifications for Autophinib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Autophinib

The following data is based on the product molecular weight 346.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.42 mL	72.10 mL	144.20 mL
1 mM	2.88 mL	14.42 mL	28.84 mL
2 mM	1.44 mL	7.21 mL	14.42 mL
10 mM	0.29 mL	1.44 mL	2.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Robke Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28544137
• Richters Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 2015 PMID: 25540906

Product Documents for Autophinib