Autophinib

Catalog # Availability Size / Price Qty
6324/50
6324/10
Cat.No. 6324 - Autophinib | C14H11ClN6O3 | CAS No. 1644443-47-9
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Description: Potent VPS34 inhibitor

Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine

Purity: ≥98%

Product Details
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Biological Activity

Potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).

Technical Data

M.Wt:
346.73
Formula:
C14H11ClN6O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1644443-47-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Identification and further development of potent TBK1 inhibitors.
    Richters et al.
    ACS Chem Biol., 2015;10:289
  2. Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.
    Robke et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:8153

Product Datasheets

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