Autophinib
Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity: ≥98%
Biological Activity
Autophinib is a potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
Identification and further development of potent TBK1 inhibitors.
Richters et al.
ACS Chem Biol., 2015;10:289 -
Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.
Robke et al.
Angew.Chem.Int.Ed.Engl., 2017;56:8153
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Autophinib
There are currently no reviews for this product. Be the first to review Autophinib and earn rewards!
Have you used Autophinib?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
