Axin-2 Antibody (S06-3A8)

Novus Biologicals | Catalog # NBP3-14909

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-3A8 expressed in HEK293
View all Axin-2 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human Axin-2 (Uniprot#: Q9Y2T1)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

94 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Axin-2 Antibody (S06-3A8)

Western Blot: Axin-2 Antibody (S06-3A8) [NBP3-14909]

Western Blot: Axin-2 Antibody (S06-3A8) [NBP3-14909]

Western Blot: Axin-2 Antibody (S06-3A8) [NBP3-14909] - Western blot detection of Axin-2 in K562, C6, 3T3, Hela cell lysates using Axin-2 Rabbit mAb (1:1000 diluted). Predicted band size: 94kDa. Observed band size: 94kDa.

Applications for Axin-2 Antibody (S06-3A8)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Axin-2

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. (provided by RefSeq)

Long Name

Axis Inhibitor 2

Alternate Names

AXIL, Axin2, Conductin, MGC10366, MGC126582

Gene Symbol

AXIN2

Additional Axin-2 Products

Product Documents for Axin-2 Antibody (S06-3A8)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Axin-2 Antibody (S06-3A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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