Catalog Number: 1763
Biological Activity
Endogenous peptide fragment that is a selective agonist for the sensory neuron specific receptor (EC50 values are 28 and 14 nM for SNSR3 and SNSR4 respectively); first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors.
Technical Data
  • M.Wt:
    1971.22
  • Formula:
    C91H127N25O23S
  • Sequence:
    VGRPEWWMDYQKRYG
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    412961-36-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
    Chen and Ikeda
    J.Neurosci., 2004;24:5044
  2. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
    Lembo et al.
    Nat.Neurosci., 2002;5:201
  3. Two faces for an opioid peptide - and more receptors for pain research.
    Simonin and Kieffer
    Nat.Neurosci., 2002;5:185
Citations:

The citations listed below are publications that use Tocris products. Selected citations for BAM (8-22) include:

2 Citations: Showing 1 - 2
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  1. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
    Authors: Hin Et al.
    Bioorg Med Chem 2014;22:5831
  2. Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
    Authors: Moser and Giesler
    J Neurosci 2013;33:6093

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