Biological ActivityBAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Chen and Ikeda
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
Lembo et al.
Two faces for an opioid peptide - and more receptors for pain research.
Simonin and Kieffer
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Citations for BAM (8-22)
The citations listed below are publications that use Tocris products. Selected citations for BAM (8-22) include:
5 Citations: Showing 1 - 5
Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension.
Authors: Grundy Et al.
BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
Authors: Sanjel Et al.
Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with CP-induced cystitis.
Authors: Honda Et al.
Cent European J Urol 2019;72:142
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Authors: Hin Et al.
Bioorg Med Chem 2014;22:5831
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Authors: Moser and Giesler
J Neurosci 2013;33:6093
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