Potent IP receptor agonist; analog of Epoprostenol
(Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro
values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo
. Orally active.
Soluble to 25 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation.
Miyamoto et al.
Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat.
Saito et al.
Nihon Kyobu Shikkan Gakkai Zasshi., 1995;33:497