BMPR-IA/ALK-3 Antibody

Novus Biologicals | Catalog # NB100-41375

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all BMPR-IA/ALK-3 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KSDSDQKKSEN corresponding to internal region according to NP_004320.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for BMPR-IA/ALK-3 Antibody

Western Blot: BMPR-IA/ALK-3 Antibody [NB100-41375]

Western Blot: BMPR-IA/ALK-3 Antibody [NB100-41375]

Western Blot: BMPR-IA/ALK-3 Antibody [NB100-41375] - (1ug/ml) staining of HeLa cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for BMPR-IA/ALK-3 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in lysates of HeLa and HepG2 (calculated MW of 60.2 kDa band according to NP_004320.2). An additional band of 20 kDa band was consistently observed, however this band was not blocked by the immunizing peptide and it is therefore a non-specific signal. We call for caution when used for other assays than WB.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: BMPR-IA/ALK-3

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Long Name

Bone Morphogenetic Protein Receptor IA/Activin Receptor-like Kinase 3

Alternate Names

ALK-3, BMPR1A, BMPRIA, CD292

Entrez Gene IDs

657 (Human)

Gene Symbol

BMPR1A

UniProt

NP_004320.2 (Human)

Additional BMPR-IA/ALK-3 Products

Product Documents for BMPR-IA/ALK-3 Antibody

Certificate of Analysis

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Product Specific Notices for BMPR-IA/ALK-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for BMPR-IA/ALK-3 Antibody

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