Catalog Number: 5983
Chemical Name: 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
Biological Activity
Potent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.
Technical Data
  • M.Wt:
    470.61
  • Formula:
    C31H34O4
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    684238-37-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
    Burford et al.
    J.Med.Chem., 2015;58:4220
  2. Proposed mode of binding and action of positive allosteric modulators at opioid receptors.
    Shang et al.
    ACS Chem.Biol., 2016;11:1220
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