BMS 986187

Key Product Details

Product Description

BMS 986187 is a potent δ-opioid receptor positive allosteric modulator (EC₅₀ = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu⁵]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.

Product Specifications for BMS 986187

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BMS 986187

The following data is based on the product molecular weight 470.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.62 mL	53.12 mL	106.25 mL
1 mM	2.12 mL	10.62 mL	21.25 mL
2 mM	1.06 mL	5.31 mL	10.62 mL
10 mM	0.21 mL	1.06 mL	2.12 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Shang Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 2016 PMID: 26841170
• Burford Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 2015 PMID: 25901762

Product Documents for BMS 986187