Cadherin-23 Antibody

Name: Cadherin-23 Antibody
Brand: Novus Biologicals
SKU: NBP1-20898
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-20898

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-YNISLYENVTVGTS corresponding to internal region according to NP_071407.3, NP_443068.1.

Epitope

C terminus

Specificity

This antibody is expected to recognize both reported isoforms (NP_071407.3; NP_443068.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Cadherin-23 Antibody

Western Blot: Cadherin-23 Antibody [NBP1-20898]

Western Blot: CDH23 Antibody [NBP1-20898] - Analysis of CDH23 in Human Amygdala lysate (35ug protein in RIPA buffer). Detected by chemiluminescence using this antibody at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Cadherin-23 Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:1000

Western Blot

1 - 3 ug/ml

Application Notes

WB: Approx. 60 kDa band observed in human brain (amygdala and frontal cortex lysates (calculated MW of 58.6 kDa band according to NP_443068.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cadherin-23

This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is a large, single-pass transmembrane protein composed of an extracellular domain containing 27 repeats that show significant homology to the cadherin ectodomain. Expressed in the neurosensory epithelium, the protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Two alternative splice variants have been identified that encode different isoforms. Additional variants have been observed but their full-length nature has not been determined.

Alternate Names

cadherin related 23, cadherin-23, cadherin-like 23, cadherin-related 23, cadherin-related family member 23, CDHR23, DKFZp434P2350, FLJ00233, FLJ36499, KIAA1774, KIAA1812, MGC102761, Otocadherin, USH1D

Entrez Gene IDs

64072 (Human)

Gene Symbol

CDH23

UniProt

Q9H251 (Human)

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Certificate of Analysis

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Product Specific Notices for Cadherin-23 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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