Ceefourin 1

Key Product Details

Product Description

Ceefourin 1 is a selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC₅₀ = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684). Ceefourin 1 inhibits cAMP efflux from acute myeloid leukemia cells (AML) and promotes apoptosis in combination with Histamine (Cat. No. 3545).

Product Specifications for Ceefourin 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ceefourin 1

The following data is based on the product molecular weight 294.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.98 mL	33.97 mL
5 mM	0.68 mL	3.40 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Sahores Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine. Biochim.Biophys.Acta 2023 PMID: 36773726
• Cheung High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 2014 PMID: 24973542

Product Documents for Ceefourin 1