Cystic fibrosis transmembrane conductance regulator (CFTR) is a multi-pass transmembrane protein that functions as a chloride channel. CFTR belongs to the ATP-binding cassette (ABC) superfamily. Mutations in CFTR cause the pulmonary disease, cystic fibrosis (CF). Specifically, deletion of phenyalanine at position 508 (DeltaF508-CFTR) results in a folding defect which impairs chloride channel function. The mechanism by which channel dysfunction relates to disease symptoms is a focus of intense research. CFTR dysfunction results in disruption of ion transport and subsequent blockage of airways by secreted mucus. CFTR may also play a role in the skeletal muscle atrophy and dysfunction that characterizes CF. In addition, CFTR-mediated chloride secretion underlies fluid accumulation and cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
Human CFTR ELISA Kit (Colorimetric)
Novus Biologicals | Catalog # NBP2-75258
Key Product Details
Sample Type & Volume Required Per Well
Sensitivity
Assay Range
Product Specifications
Assay Type
Kit Type
Species
Specificity
Precision
Intra-Assay Precision (Precision within an assay) CV% 5.5%
Inter-Assay Precision (Precision between assays) CV% 4.79%
Recovery for Human CFTR ELISA Kit (Colorimetric)
Recovery
Linearity
Scientific Data Images for Human CFTR ELISA Kit (Colorimetric)
ELISA: Human CFTR ELISA Kit (Colorimetric) [NBP2-75258] -
ELISA: Human CFTR ELISA Kit (Colorimetric) [NBP2-75258] - Standard Curve ReferenceKit Contents for Human CFTR ELISA Kit (Colorimetric)
- Biotinylated Detection Ab Diluent
- Concentrated Biotinylated Detection Ab (100x)
- Concentrated HRP Conjugate (100x)
- Concentrated Wash Buffer (25x)
- HRP Conjugate Diluent
- Micro ELISA Plate (Dismountable)
- Plate Sealer
- Product Manual
- Reference Standard
- Sample Diluent
- Stop Solution
- Substrate Reagent
Preparation and Storage
Shipping
Stability & Storage
Background: CFTR
Long Name
Alternate Names
Gene Symbol
Additional CFTR Products
Product Documents for Human CFTR ELISA Kit (Colorimetric)
Certificate of Analysis
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Product Specific Notices for Human CFTR ELISA Kit (Colorimetric)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.
Related Research Areas
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Protocols
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- Troubleshooting Guide: ELISA
- View all Protocols, Troubleshooting, Illustrated assays and Webinars
Associated Pathways
