Neurotransmitter Receptors, Transporters, and Ion Channels

Neurotransmitter receptors are expressed on the surface of post-synaptic cells to bind ligand-specific neurotransmitters and hormones. They are also expressed on presynaptic cells to provide feedback mechanisms and attenuate excessive neurotransmitter release. The majority of neurotransmitter receptors are integral membrane proteins with seven transmembrane domains, commonly coupled to G-proteins. Binding of a ligand to its specific neurotransmitter receptor may result in the activation of a myriad of cell signal transduction pathways and modulation of ion channel homeostasis. R&D Systems offers quality products for experiments focused on the role of dopamine, gamma-aminobutyric acid (GABA), glutamate, N-methyl-D-aspartic acid (NMDA), thrombin and more.

Neurotransmitter Receptors

Corticotropin-releasing Hormone Receptors CRHR1 CRHR2	Nicotinic Acetylcholine Receptors (View All) Nicotinic Acetylcholine R alpha 1/CHRNA1 Nicotinic Acetylcholine R alpha 2/CHRNA2 Nicotinic Acetylcholine R alpha 3/CHRNA3 Nicotinic Acetylcholine R alpha 4/CHRNA4 Nicotinic Acetylcholine R alpha 5/CHRNA5 Nicotinic Acetylcholine R alpha 6/CHRNA6 Nicotinic Acetylcholine R alpha 7/CHRNA7 Nicotinic Acetylcholine R alpha 9/CHRNA9 Nicotinic Acetylcholine R alpha 10/CHRNA10 Nicotinic Acetylcholine R beta 1/CHRNB1 Nicotinic Acetylcholine R beta 2/CHRNB2 Nicotinic Acetylcholine R beta 3/CHRNB3 Nicotinic Acetylcholine R beta 4/CHRNB4 Nicotinic Acetylcholine R delta/CHRND Nicotinic Acetylcholine R epsilon/CHRNE Nicotinic Acetylcholine R gamma/CHRNG
Glycine Receptors GLRA1 Glycine R Glycine Receptor Agonists	Proteinase-Activated Receptor PAR1 PAR2 PAR3 PAR4
Leukotriene Receptors Leukotriene B4 R1 Leukotriene B4 R2	SEZ6 Receptors SEZ6/BSRP-C SEZ6L SEZ6L2/BSRP-A
Melanin-concentrating Hormone Receptors MCHR1 MCHR2	TRPV Family Vanilloid R1/TRPV1 Vanilloid R-like 3/TRPV3 TRPV5 TRPV6
Muscarinic Cholinergic Receptors CHRM1 CHRM2 CHRM3 CHRM4 CHRM5	Other Neurotransmitter Receptors CFTR Growth Hormone R/GHR KOR Leptin R NPY5R PTH2R VIPR2

Neurotransmitter Transporters

Neurotransmitter transporters are a group of transmembrane proteins that carry neurotransmitters across biological membranes to specific cellular and subcellular locations. They are found in the plasma membrane of neurons and glia and many members of this family are sodium-dependent. They often rely on an electrochemical gradient across the membrane to provide energy for neurotransmitter transport, for example Na⁺ cotransport provides the energy necessary for glutamate transport. Neurotransmitter transporters are found at high concentrations in synaptic clefts where they act to terminate the effects of the neurotransmitter by removing it from the cleft.

5-HT Transporters 5-HT Transporter Compounds 5-HT Transporter Inhibitors	Glycine Transporters GlyT1/SLC6A9 GlyT2/SLC6A5 Glycine Transporter Inhibitors
Adrenergic Transporters Adrenergic Transporter Compounds Adrenergic Transporter Inhibitors Adrenergic Transporter Substrates	Nucleoside Transporters Nucleoside Transporter Inhibitors
Cannabinoid Transporters Cannabinoid Transporter Inhibitors	SLC6 Transporters GAT-1/SLC6A1 SLC6A2/NET SLC6A3/DAT1 SLC6A4/5-HTTLPR TauT/SLC6A6 SLC6A7 SLC6A8
Dipeptidyl Peptidase IV Transporters DPP6 DPP10	Other SLC Transporters xCT/SLC7A11 SLC12A3 SLC13A1 SLC13A3/NaDC3 MCT8/SLC16A2 Sialin/SLC17A5 VGLUT1/SLC17A7 SLC22A1 SLC22A2/OCT2 VIAAT/SLC32A1 SLC39A4 SLCO1C1/OATP1C1
Dopamine Transporters Dopamine Transporter Inhibitors	Pannexin Transporters Pannexin-1 Pannexin-2 Pannexin-3
GABA Transporters GABA Inhibitors	Vesicular Monoamine Transporters VMAT1/SLC18A1 VMAT2 Vesicular Monoamine Transporter Inhibitors Additional VMAT Products
Glutamate Transporters (EAAT) EAAT1/GLAST-1 EAAT2/GLT1 Glutamate Transporter Modulators Glutamate Transporter Inhibitors	Other Neurotransmitter Transporters Nucleoporin NUP85 Polycystin-1/PKD1

Neurotransmitter transporters are of great clinical interest. They are the pharmacological target of many drugs in the treatment of depression (for example serotonin-noradrenalin reuptake inhibitors (SNRIs)), epilepsy and schizophrenia. In addition, narcotics such as cocaine exert their effects through actions on this class of transporters.

Neurotransmitter Receptors, Transporters, and Ion Channels

Neurotransmitter Receptors

Neurotransmitter Transporters

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