CGP 7930
Chemical Name: 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol
Purity: ≥98%
Biological Activity
CGP 7930 is a positive allosteric modulator of GABAB receptors. Increases the potency and efficacy of GABA at both native and recombinant GABAB receptors (EC50 values are 5.37 and 4.60μM respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Differential modulation by the GABAB receptor allosteric potentiator 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area.
Chen et al.
J.Pharmacol.Exp.Ther., 2006;317:1170 -
The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats.
Liang et al.
Neuropharmacology, 2006;50:632 -
Positive allosteric modulation of native and recombinant γ-aminobutyric acidB receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.
Urwyler et al.
Mol.Pharmacol., 2001;60:963
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Citations for CGP 7930
The citations listed below are publications that use Tocris products. Selected citations for CGP 7930 include:
3 Citations: Showing 1 - 3
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GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Authors: Zhang Et al.
PLoS One 2015;5:10468
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GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
Authors: Tu Et al.
J Neurosci 2010;30:749
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.
Authors: Rondard Et al.
EMBO J 2008;27:1321
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