Catalog Number: 0289
Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole
Biological Activity
Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors.
    Akhondzadeh and Stone
    Br.J.Pharmacol., 1995;115:527
  2. The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo.
    Gleason et al.
    J.Appl.Physiol., 2009;106:1257
  3. Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors.
    Jafari-Sabet and Jannat-Dastjerdi
    Behav.Brain Res., 2009;202:5
  4. GABAC receptors: relatively simple transmitter-gated ion channels?
    TiPS, 1996;17:319
  5. Central actions of ibotenic acid and muscimol.
    Johnston et al.
    Biochem.Pharmacol., 1968;17:2488

The citations listed below are publications that use Tocris products. Selected citations for Muscimol include:

Showing Results 1 - 10 of 32

  1. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα.
    Authors: Chen Et al.
  2. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    PLoS One
  3. The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast.
    Authors: Parent Et al.
    Neurobiol Dis
  4. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Authors: Sivakumaran Et al.
  5. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci
  6. Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
    Authors: Wang Et al.
    J Neurosci
  7. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Front Integr Neurosci
  8. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast
  9. The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
    Authors: Kangarlu-Haghighi Et al.
    Sci Rep
  10. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    PLoS One
  11. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    J Biol Chem
  12. Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
    Authors: Hengen Et al.
    PLoS One
  13. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One
  14. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Neurobiol Learn Mem
  15. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
  16. Motor cortex feedback influences sensory processing by modulating network state.
    Authors: Zagha Et al.
  17. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Mol Cell Biol
  18. The contribution of synaptic location to inhibitory gain control in pyramidal cells.
    Authors: Pouille Et al.
    Physiol Rep
  19. Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus.
    Authors: Maclaren Et al.
    PLoS Comput Biol
  20. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One
  21. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    Front Cell Neurosci
  22. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci
  23. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    J Pharmacol Exp Ther
  24. Development of asymmetric inhibition underlying direction selectivity in the retina.
    Authors: Wei Et al.
    J Biol Chem
  25. Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
    Authors: Porcher Et al.
  26. Developmental regulation and neuroprotective effects of striatal tonic GABAA currents.
    Authors: Santhakumar Et al.
  27. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
  28. Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning.
    Authors: Kalmbach Et al.
    Learn Mem
  29. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol
  30. Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight.
    Authors: Manookin Et al.
    J Neurosci
  31. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol
  32. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol
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