Muscimol

  ( 39 citations )    
Product Datasheet
Catalog Number:0289
Chemical Name:5-Aminomethyl-3-hydroxyisoxazole
Product Details
Citations (39)
Reviews
Biological Activity
Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.
Technical Data
  • M.Wt:
    114.1
  • Formula:
    C4H6N2O2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    2763-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Muscimol include:

39 Citations: Showing 1 - 10
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  1. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience  2017;349:341
  2. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα.
    Authors: Chen Et al.
    Nature  2016;6:26554
  3. Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task
    Authors: Nasehi Et al.
    Neuroscience  2016;339:287
  4. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    PLoS One  2015;9:290
  5. The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast.
    Authors: Parent Et al.
    Neurobiol Dis  2015;9:23
  6. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
    Authors: Grosso Et al.
    Nat Commun  2015;6:8886
  7. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Authors: Sivakumaran Et al.
    EXCLI J  2015;35:8291
  8. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci  2015;35:5625
  9. Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
    Authors: Wang Et al.
    J Neurosci  2015;35:1712
  10. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Front Integr Neurosci  2015;352:156
  11. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast  2015;2015:924728
  12. The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
    Authors: Kangarlu-Haghighi Et al.
    Sci Rep  2015;14:613
  13. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    PLoS One  2015;142:3178
  14. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    J Biol Chem  2015;10:e0131076
  15. Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
    Authors: Hengen Et al.
    PLoS One  2015;10:e0119351
  16. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  17. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Neurobiol Learn Mem  2014;259:53
  18. Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice.
    Authors: Shah Et al.
    Biomol Ther (Seoul)  2014;22:314
  19. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Neuroscience  2014;12:47
  20. Motor cortex feedback influences sensory processing by modulating network state.
    Authors: Zagha Et al.
    Neuron  2013;79:567
  21. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Mol Cell Biol  2013;238:29
  22. The contribution of synaptic location to inhibitory gain control in pyramidal cells.
    Authors: Pouille Et al.
    Physiol Rep  2013;1:e00067
  23. Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus.
    Authors: Maclaren Et al.
    PLoS Comput Biol  2013;102:28
  24. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  25. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    Front Cell Neurosci  2012;7:e35024
  26. Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
    Authors: Ilie Et al.
    J Neurosci  2012;32:5321
  27. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  28. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  29. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    J Pharmacol Exp Ther  2011;7:e1002149
  30. Development of asymmetric inhibition underlying direction selectivity in the retina.
    Authors: Wei Et al.
    J Biol Chem  2011;469:402
  31. Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
    Authors: Porcher Et al.
    Neuroscience  2011;286:21667
  32. Developmental regulation and neuroprotective effects of striatal tonic GABAA currents.
    Authors: Santhakumar Et al.
    Development  2010;167:644
  33. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    Neuroscience  2009;284:8726
  34. Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning.
    Authors: Kalmbach Et al.
    Learn Mem  2009;16:86
  35. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol  2009;157:666
  36. Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight.
    Authors: Manookin Et al.
    J Neurosci  2008;28:4136
  37. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  38. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol  2007;98:1634
  39. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol  2004;142:1038
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