Muscimol

Catalog # Availability Size / Price Qty
0289/10
0289/50
0289/1
Muscimol | CAS No. 2763-96-4 | GABA-A Receptor Agonists
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Description: Potent GABAA agonist; also GABAA-ρ partial agonist

Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole

Purity: ≥98%

Product Details
Citations (45)
Reviews

Biological Activity

Muscimol is a potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data

M.Wt:
114.1
Formula:
C4H6N2O2
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
2763-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Muscimol

The citations listed below are publications that use Tocris products. Selected citations for Muscimol include:

45 Citations: Showing 1 - 10

  1. Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
    Authors: Kramer Et al.
    ELife  2020;9
  2. Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice.
    Authors: Namikawa Et al.
    Front Aging Neurosci  2018;9:395
  3. Local GABAA receptor mediated suppression of DA release within the nucleus accumbens.
    Authors: Brodnik Et al.
    ACS Chem Neurosci  2018;17:1978
  4. Septal and Hippocampal Neurons Contribute to Auditory Relay and Fear Conditioning.
    Authors: Xiao Et al.
    Front Cell Neurosci  2018;12:102
  5. Discrete Circuits Support Generalized versus Context-Specific Vocal Learning in the Songbird.
    Authors: Tian and Brainard
    Neuron  2017;96:1168
  6. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
    Authors: David-Pereira
    Neuroscience  2017;349:341
  7. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα.
    Authors: Chen Et al.
    Nature  2016;6:26554
  8. Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task
    Authors: Nasehi Et al.
    Neuroscience  2016;339:287
  9. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    PLoS One  2015;9:290
  10. The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast.
    Authors: Parent Et al.
    Neurobiol Dis  2015;9:23
  11. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
    Authors: Grosso Et al.
    Nat Commun  2015;6:8886
  12. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Authors: Sivakumaran Et al.
    EXCLI J  2015;35:8291
  13. Context-induced reinstatement of methA. seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
    Authors: Rubio Et al.
    J Neurosci  2015;35:5625
  14. Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
    Authors: Wang Et al.
    J Neurosci  2015;35:1712
  15. NMDA receptor channel blocker-like discriminative stimulus effects of NO gas.
    Authors: Richardson and Shelton
    Front Integr Neurosci  2015;352:156
  16. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast  2015;2015:924728
  17. The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
    Authors: Kangarlu-Haghighi Et al.
    Sci Rep  2015;14:613
  18. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    PLoS One  2015;142:3178
  19. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    J Biol Chem  2015;10:e0131076
  20. Daily isoflu. exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs.
    Authors: Hengen Et al.
    PLoS One  2015;10:e0119351
  21. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
    Authors: Xia Et al.
    PLoS One  2014;9:e100968
  22. GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status.
    Authors: Tashiro Et al.
    Neurobiol Learn Mem  2014;259:53
  23. Pachymic Acid Enhances Drug-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice.
    Authors: Shah Et al.
    Biomol Ther (Seoul)  2014;22:314
  24. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Authors: Pandya and Pillai
    Neuroscience  2014;12:47
  25. Motor cortex feedback influences sensory processing by modulating network state.
    Authors: Zagha Et al.
    Neuron  2013;79:567
  26. The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
    Authors: Wagner Et al.
    Mol Cell Biol  2013;238:29
  27. The contribution of synaptic location to inhibitory gain control in pyramidal cells.
    Authors: Pouille Et al.
    Physiol Rep  2013;1:e00067
  28. PF inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
    Authors: Yang Et al.
    J Immunol  2013;190:6511
  29. Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus.
    Authors: Maclaren Et al.
    PLoS Comput Biol  2013;102:28
  30. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
    Authors: Ring Et al.
    PLoS One  2012;7:e36874
  31. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    Front Cell Neurosci  2012;7:e35024
  32. Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
    Authors: Ilie Et al.
    J Neurosci  2012;32:5321
  33. The loop diuretic compound blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci  2012;32:1757
  34. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  35. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    J Pharmacol Exp Ther  2011;7:e1002149
  36. Development of asymmetric inhibition underlying direction selectivity in the retina.
    Authors: Wei Et al.
    J Biol Chem  2011;469:402
  37. Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons.
    Authors: Porcher Et al.
    Neuroscience  2011;286:21667
  38. Developmental regulation and neuroprotective effects of striatal tonic GABAA currents.
    Authors: Santhakumar Et al.
    Development  2010;167:644
  39. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    Neuroscience  2009;284:8726
  40. Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning.
    Authors: Kalmbach Et al.
    Learn Mem  2009;16:86
  41. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
    Authors: Yoon Et al.
    Br J Pharmacol  2009;157:666
  42. Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight.
    Authors: Manookin Et al.
    J Neurosci  2008;28:4136
  43. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  44. Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
    Authors: Milenković Et al.
    J Neurophysiol  2007;98:1634
  45. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol  2004;142:1038

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