CHIR 99021 trihydrochloride
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
Purity: ≥98%
Biological Activity
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AKT kinase activity is required for Li to modulate mood-related behaviors in mice.
Pan et al.
Neuropsychopharmacology, 2011;36:1397 -
Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo.
Ring et al.
Diabetes, 2003;52:588 -
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains.
Ye et al.
PLoS One, 2012;7:e35892
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Citations for CHIR 99021 trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CHIR 99021 trihydrochloride include:
4 Citations: Showing 1 - 4
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A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
Authors: Ward and Gilad
Elife 2019;8
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Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.
Authors: Modic Et al.
Mol Cell 2019;74:951
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A promoter interaction map for cardiovascular disease genetics.
Authors: Montefiori Et al.
Elife 2018;7
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Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential.
Authors: Judson Et al.
Cell Stem Cell 2018;22:177
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