CHIR 99021 trihydrochloride
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
Biological ActivityHydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AKT kinase activity is required for Li to modulate mood-related behaviors in mice.
Pan et al.
Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo.
Ring et al.
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains.
Ye et al.
PLoS One, 2012;7:e35892
Citation for CHIR 99021 trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CHIR 99021 trihydrochloride include:
1 Citation: Showing 1 - 1
Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential.
Authors: Judson Et al.
Cell Stem Cell 2018;22:177
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