CHIR 99021 trihydrochloride
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
Biological ActivityHydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Pan et al.
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Ring et al.
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains.
Ye et al.
PLoS One, 2012;7:e35892
Citation for CHIR 99021 trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CHIR 99021 trihydrochloride include:
1 Citation: Showing 1 - 1
Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential.
Authors: Judson Et al.
Cell Stem Cell 2018;22:177
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