CHIR 99021 trihydrochloride

Key Product Details

Product Description

CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.

CHIR 99021, CHIR 99021 in solution and CHIR 99021 synthesized to cGMP guidelines also available.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.

Product Specifications for CHIR 99021 trihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CHIR 99021 trihydrochloride

The following data is based on the product molecular weight 574.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.48 mL	17.40 mL	34.80 mL
2.5 mM	0.70 mL	3.48 mL	6.96 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

• Ring Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003 PMID: 12606497
• Ye Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 2012 PMID: 22540008
• Pan AKT kinase activity is required for Li to modulate mood-related behaviors in mice. Neuropsychopharmacology 2011 PMID: 21389981

Product Documents for CHIR 99021 trihydrochloride