CHIR 99021 in solution

Tocris Bioscience | Catalog # 8170

Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
Tocris Bioscience
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Key Product Details

Description

Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
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Product Description

CHIR 99021 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of CHIR 99021 (Cat. No. 4423) pre-dissolved in DMSO. A potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Acts as Wnt activator. In combination with the irreversible inhibitor of LSD1, Tranylcypromine (Cat. No. 3852), CHIR 99021 enables reprogramming of mouse embryonic fibroblasts into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192); promotes differentiation of hPSCs in cardiomyocytes and allows formation of extended pluripotent stem (EPS) cells in combination with (S)-(+)-Dimethindene maleate (Cat. No. 1425), Minocycline (Cat. No. 3268) and human leukemia inhibitory factor.

CHIR 99021 synthesized to cGMP guidelines also available.

Product Specifications for CHIR 99021 in solution

Molecular Weight

465.34

Formula

C22H18Cl2N8

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

CAS Number

252917-06-9

PubChem ID

9956119

InChI Key

AQGNHMOJWBZFQQ-UHFFFAOYSA-N

SMILES

ClC(C=C1Cl)=CC=C1C2=NC(NCCNC3=CC=C(C#N)C=N3)=NC=C2C4=NC=C(C)N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for CHIR 99021 in solution

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CHIR 99021 in solution

For research use only

Related Research Areas

Notch Pathway

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