Catalog Number: 5329
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Biological Activity
Casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
    Rena et al.
    EMBO Rep., 2004;5:60
  2. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.
    Osakada et al.
    J.Cell Sci., 2009;122:3169
  3. 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ.
    Peifer et al.
    J.Med.Chem., 2009;52:7618
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information