CKI 7 dihydrochloride
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Biological ActivityCKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.
Osakada et al.
J.Cell Sci., 2009;122:3169
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
Rena et al.
EMBO Rep., 2004;5:60
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ.
Peifer et al.
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