CKI 7 dihydrochloride

Key Product Details

Product Description

CKI 7 dihydrochloride is a casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

Product Specifications for CKI 7 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CKI 7 dihydrochloride

The following data is based on the product molecular weight 358.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.58 mL	27.88 mL	55.76 mL
2.5 mM	1.12 mL	5.58 mL	11.15 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Rena D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 PMID: 14710188
• Peifer 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 2009 PMID: 19591487
• Osakada In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 2009 PMID: 19671662

Product Documents for CKI 7 dihydrochloride