SB 431542

GMP Version Available: TB1614-GMP
Catalog # Availability Size / Price Qty
SB 431542 | CAS No. 301836-41-9 | TGF-beta Receptor Inhibitors
1 Image
Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Purity: ≥99%

Product Details
Citations (259)
Supplemental Products
Reviews (10)

Biological Activity

SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs.

Applications in hiPSCs

 Dopaminergic Neurons Derived from hiPSCs using SB 431542

Dopaminergic Neurons Derived from hiPSCs using SB 431542

Dopaminergic neurons derived from human induced pluripotent stem cells (hiPSC) using SB 431542, CHIR 99021 (Cat. No. 4423), DAPT (Cat. No. 2634) and Purmorphamine (Cat. No. 4551). Cells cultured in Neuronal Media supplemented with TGF-3 (Cat. No. 8420-B3, R&D Systems), cAMP, GDNF (Cat. No. 212-GD, R&D Systems), BDNF (Cat. No. 248-BDB, R&D Systems), N21-MAX (Cat. No. AR008, R&D Systems). Differentiation shown at days 55 (left) and 62 (right). Images courtesy of Kevin Flynn, Bio-Techne.

Technical Data

Soluble to 10 mM in ethanol and to 100 mM in DMSO with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SB 431542

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

259 Citations: Showing 1 - 10

  1. Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use.
    Authors: Kim Et al.
    Cell Stem Cell  2021;28:343
  2. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
    Authors: piao Et al.
    Cell Stem Cell  2021;28:217
  3. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: Yang Et al.
    Cell Stem Cell  2020;27:125
  4. Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
    Authors: Frith and Tsakiridis
    Curr Protoc Stem Cell Biol  2019;:e81
  5. Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
    Authors: Baror Et al.
    Glia  2019;67:1374
  6. Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities.
    Authors: Yin Et al.
    Eneuro  2019;6
  7. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart.
    Authors: Bise Et al.
    NPJ Regen Med  2019;4:2
  8. Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
    Authors: Sharma Et al.
    Arterioscler Thromb Vasc Biol  2019;39:212
  9. Long-term functional maintenance of primary human hepatocytes in vitro.
    Authors: Xiang Et al.
    Science  2019;364:399
  10. A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
    Authors: Serrano Et al.
    Stem Cells Dev  2019;28:81
  11. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
    Authors: Paonessa Et al.
    Cell Rep  2019;26:582
  12. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
    Authors: Colunga Et al.
    Cell Rep  2019;26:2566
  13. Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome.
    Authors: Balbi Et al.
    Data Brief  2019;25:104324
  14. Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
    Authors: Lang Et al.
    Cell Stem Cell  2019;24:93
  15. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
    Authors: Montel-Hagen Et al.
    Cell Stem Cell  2019;24:376
  16. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches.
    Authors: Varghese Et al.
    Stem Cells Int  2019;2019:5968236
  17. Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
    Authors: Nguyen Et al.
    Stem Cells Int  2019;2019:3298432
  18. Reliability of human cortical organoid generation.
    Authors: Yoon Et al.
    Nat Methods  2019;16:75
  19. The Spatiotemporal Control of Zygotic Genome Activation.
    Authors: Gentsch Et al.
    iScience  2019;16:485
  20. An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.
    Authors: Canfield Et al.
    Fluids Barriers CNS  2019;16:25
  21. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
    Authors: Haidar Et al.
    Autophagy  2019;15:1051
  22. A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology.
    Authors: Yoshimatsu Et al.
    PLoS One  2019;14:e0221164
  23. Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.
    Authors: Aquino-Martínez Et al.
    PLoS One  2019;14:e0210301
  24. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  25. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
    Authors: Yin Et al.
    Stem Cell Reports  2019;12:488
  26. Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
    Authors: Easterbrook Et al.
    Stem Cell Reports  2019;12:1056
  27. Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals.
    Authors: Gentsch Et al.
    Nat Commun  2019;10:4269
  28. Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
    Authors: Caron Et al.
    Stem Cell Res Ther  2019;10:221
  29. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  30. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  31. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  32. Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
    Authors: Yang Et al.
    Sci Rep  2018;8:8495
  33. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
    Authors: Bayo-Puxan Et al.
    Sci Rep  2018;8:16644
  34. Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
    Authors: Hsu Et al.
    Elife  2018;7
  35. Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling.
    Authors: Subramanian Et al.
    Elife  2018;7
  36. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
    Authors: Smyth Et al.
    Int J Parasitol  2018;48:379
  37. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
    Authors: McCauley Et al.
    Curr Protoc Stem Cell Biol  2018;45:e51
  38. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
    Authors: Noskovičová Et al.
    Am J Physiol Lung Cell Mol Physiol  2018;314:L695
  39. Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
    Authors: Bernard Et al.
    J Biol Chem  2018;293:1218
  40. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
    Authors: Mehta Et al.
    Cell Rep  2018;25:1081
  41. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
    Authors: Wang
    Nat Med  2018;24(5):647
  42. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
    Authors: Nehme Et al.
    Cell Rep  2018;23:2509
  43. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  44. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.
    Authors: Tebbenkamp Et al.
    Cell  2018;175:1088
  45. Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
    Authors: Wu Et al.
    Cell  2018;172:423
  46. MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo.
    Authors: Molina Et al.
    PLoS Genet  2018;14:e1007621
  47. Generation and assembly of human brain region-specific three-dimensional cultures.
    Authors: Sloan Et al.
    Nat Protoc  2018;13:2062
  48. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
    Authors: Raykhel Et al.
    J Cell Sci  2018;131
  49. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
    Authors: Li Et al.
    Stem Cell Reports  2018;11:998
  50. Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
    Authors: Fr?hlich Et al.
    Front Mol Neurosci  2018;11:81
  51. TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
    Authors: Albers Et al.
    Int J Stem Cells  2018;11:111
  52. Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
    Authors: Medelnik Et al.
    Stem Cell Reports  2018;10:1751
  53. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
    Authors: Sloan Et al.
    Neuron  2017;95:779
  54. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    Authors: Offermann Et al.
    Oncotarget  2017;8:7964
  55. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  56. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
    Authors: Christoforou Et al.
    Sci Rep  2017;7:40285
  57. Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
    Authors: Kunnen Et al.
    Cell Mol Life Sci  2017;74:2283
  58. Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
    Authors: Song Et al.
    Mol Cell  2017;67:148
  59. Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory.
    Authors: Park Et al.
    Elife  2017;6
  60. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
    Authors: Takata Et al.
    Immunity  2017;47:183
  61. Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
    Authors: Charney Et al.
    Dev Cell  2017;40:595
  62. Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
    Authors: Yang Et al.
    Cell Mol Gastroenterol Hepatol  2017;3:484
  63. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
    Authors: Major Et al.
    Curr Protoc Stem Cell Biol  2017;39:1H.10.1
  64. Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer.
    Authors: Funaki Et al.
    Oncol Rep  2017;38:2277
  65. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
    Authors: Ruetz Et al.
    Cell Stem Cell  2017;21:791
  66. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  67. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  68. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
    Authors: McCauley Et al.
    Cell Stem Cell  2017;20:844
  69. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
    Authors: Saini Et al.
    Cell Stem Cell  2017;20:635
  70. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
    Authors: Bershteyn Et al.
    Cell Stem Cell  2017;20:435
  71. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  72. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC Cancer  2017;17(1):202
  73. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  74. p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
    Authors: Molina Et al.
    Development  2017;144:2270
  75. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
    Authors: Sampaziotis Et al.
    Nat Protoc  2017;12:814
  76. Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
    Authors: Bao Et al.
    Nat Protoc  2017;12:1890
  77. Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.
    Authors: Guo Et al.
    Biomaterials  2017;122:179
  78. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  79. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells  2016;8:e65580
  80. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
    Authors: Spender Et al.
    Oncotarget  2016;7:81995
  81. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy  2016;7:174
  82. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  83. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc  2016;6:21518
  84. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2016;6:19727
  85. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol  2016;6:19533
  86. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer.
    Authors: Buczek Et al.
    Oncogene  2016;35:3465
  87. Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
    Authors: Genbacev Et al.
    Hum Reprod  2016;31:1300
  88. Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
    Authors: Topalovski Et al.
    J Biol Chem  2016;291:22244
  89. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421
  90. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  91. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  92. AVNA programs the differentiation of human TFH cells.
    Authors: Locci Et al.
    Nat Immunol  2016;17:976
  93. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  94. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
    Authors: Maturana Et al.
    J Neuroinflammation  2016;13:295
  95. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens  2016;12:e1005991
  96. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One  2016;11:e0165497
  97. Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.
    Authors: Ghaedi and Niklason
    Methods Mol Biol  2016;
  98. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep  2015;89:5134
  99. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  100. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol  2015;6:8896
  101. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun  2015;6:7264
  102. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest  2015;6:5
  103. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther  2015;6:125
  104. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol  2015;63:420
  105. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer  2015;61:42626
  106. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol  2015;5:660
  107. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev  2015;5:323
  108. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo  2015;5:16872
  109. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol  2015;5:11252
  110. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest  2015;5:1010
  111. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One  2015;52:1850
  112. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest  2015;400:129
  113. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  114. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev  2015;3:e1486
  115. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med  2015;330:29
  116. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet  2015;26:205
  117. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun  2015;263:190
  118. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports  2015;24:5260
  119. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol  2015;24:2591
  120. Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain  2015;21:276
  121. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  122. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol  2015;17:615
  123. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  124. The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway.
    Authors: Wilson Et al.
    Sci Rep  2015;15:55
  125. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports  2015;142:3166
  126. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  127. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  128. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep  2015;125:3008
  129. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol  2015;125:2032
  130. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell  2015;11:e1004453
  131. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ  2015;10:e0125590
  132. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  133. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One  2015;10:e0116995
  134. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res  2015;10:413
  135. Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
    Authors: Ginsberg Et al.
    Nat Protoc  2015;10:1975
  136. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One  2014;9:e91269
  137. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis  2014;70:12
  138. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One  2014;4:7323
  139. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med  2014;3:1169
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    Dev Cell  2011;20:689
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  226. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.
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Effective inhibition of TGFb family receptors
By Paul Humphreys on 12/11/2020
Application: Species: Human

I have used SB431542 for both selective inhibition of TGFb family receptors in TGFb activity assays and to drive differentiation of pluripotent stem cells towards mesodermal tissues.Concentration: 1nM working

Differentiation to cortical neurons
By Julieta O'Flaherty on 12/11/2020
Application: Species: Human

I routinely use this product to differentiate human induced pluripotent stem cells into cortical neurons. I use it at 10uM. Once reconstituted, I would only store it for a maximum of one month in -80C

Inhibition of pSmad 2/3 in a human epithelial cell line
By Anonymous on 10/26/2020
Application: Species: Human

Tested a human lung epithelial cell line pretreated with SB431542 at either 10, 1 or 0.1uM for 30 min and then added TGFb1 at 5ng/ml in two different matrices. Incubated 24hr and then lysed cells to look at pSmad 2/3 levels by immunoassay

iPSC differentiation
By Stephanie Hsiao on 10/13/2020
Application: Species: Human

Differentiation of human iPSCs into hematopoietic progenitor cells

For hPSC culture
By Anonymous on 06/30/2020
Application: Species: Human

For hPSC culture, final concentration 10 μM.

3D cultures
By Anonymous on 02/06/2020
Application: Species: Human

Worked consistently in generation of cerebral organoids from human iPS cells

Dífferentiation of iPSC into neural progentor cells
By Vladimir Milenkovic on 01/15/2020
Application: Species: Human

Human induced pluripotent stem cells (iPSCs) were differentiated into neural progenitor cells (NPCs) as described in Chambers et al. 2009 (PMID: 19252484.) SB431542 was used at 20uM. Differentiated NPCs were then immunostained using PAX6 monoclonal Ab, and we had over 80% of PAX6 positive cells.

Works really well as a TGF-beta receptor Inhibitor
By Anonymous on 12/08/2019
Application: Species: Human

I used it as a TGF-beta receptor Inhibitor in Breast cancer Cells to study the impact of blocking TGF-beta pathway on EMT. I used the concentration 5uM and it works really well.

endothelial differentiation
By Anonymous on 05/01/2018
Application: Species: Human

Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)

Works great.
By Anonymous on 01/04/2018
Application: Species: Human

I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.

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