SB 431542

Catalog # Availability Size / Price Qty
1614/10
1614/1
1614/50
Cat.No. 1614 - SB 431542 | C22H16N4O3 | CAS No. 301836-41-9
1 Image
Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Purity: ≥99%

Product Details
Citations (192)
Supplemental Products
Reviews (2)

Biological Activity

Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

Technical Data

M.Wt:
384.39
Formula:
C22H16N4O3
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
301836-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for SB 431542

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

192 Citations: Showing 1 - 10

  1. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  2. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  3. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
    Authors: Wang
    Nat Med  2018;24(5):647
  4. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  5. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    Authors: Offermann Et al.
    Oncotarget  2017;8:7964
  6. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  7. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
    Authors: Christoforou Et al.
    Sci Rep  2017;7:40285
  8. Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
    Authors: Kunnen Et al.
    Cell Mol Life Sci  2017;74:2283
  9. Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
    Authors: Yang Et al.
    Cell Mol Gastroenterol Hepatol  2017;3:484
  10. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  11. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  12. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
    Authors: Saini Et al.
    Cell Stem Cell  2017;20:635
  13. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  14. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC Cancer  2017;17(1):202
  15. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  16. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells  2016;8:e65580
  17. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
    Authors: Spender Et al.
    Oncotarget  2016;7:81995
  18. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy  2016;7:174
  19. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  20. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc  2016;6:21518
  21. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2016;6:19727
  22. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol  2016;6:19533
  23. Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
    Authors: Topalovski Et al.
    J Biol Chem  2016;291:22244
  24. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  25. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  26. Activin A programs the differentiation of human TFH cells.
    Authors: Locci Et al.
    Nat Immunol  2016;17:976
  27. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  28. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
    Authors: Maturana Et al.
    J Neuroinflammation  2016;13:295
  29. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens  2016;12:e1005991
  30. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One  2016;11:e0165497
  31. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep  2015;89:5134
  32. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  33. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol  2015;6:8896
  34. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun  2015;6:7264
  35. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest  2015;6:5
  36. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther  2015;6:125
  37. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol  2015;63:420
  38. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer  2015;61:42626
  39. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol  2015;5:660
  40. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev  2015;5:323
  41. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo  2015;5:16872
  42. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol  2015;5:11252
  43. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest  2015;5:1010
  44. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One  2015;52:1850
  45. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest  2015;400:129
  46. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  47. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev  2015;3:e1486
  48. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med  2015;330:29
  49. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet  2015;26:205
  50. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun  2015;263:190
  51. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports  2015;24:5260
  52. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol  2015;24:2591
  53. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain  2015;21:276
  54. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  55. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol  2015;17:615
  56. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  57. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Authors: Wilson Et al.
    Sci Rep  2015;15:55
  58. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports  2015;142:3166
  59. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  60. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  61. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep  2015;125:3008
  62. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol  2015;125:2032
  63. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell  2015;11:e1004453
  64. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ  2015;10:e0125590
  65. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  66. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One  2015;10:e0116995
  67. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res  2015;10:413
  68. Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
    Authors: Ginsberg Et al.
    Nat Protoc  2015;10:1975
  69. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One  2014;9:e91269
  70. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis  2014;70:12
  71. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One  2014;4:7323
  72. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med  2014;3:1169
  73. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.
    Authors: Aguila Et al.
    Stem Cells Transl Med  2014;3:1032
  74. miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Authors: Rosa Et al.
    Dev Biol  2014;391:81
  75. Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
    Authors: Magaña Et al.
    Dev Biol  2014;387:15
  76. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
    Authors: Curado Et al.
    Exp Neurol  2014;34:4389
  77. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
    Authors: Orlova Et al.
    Arterioscler Thromb Vasc Biol  2014;34:177
  78. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  79. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    Authors: O'Reilly Et al.
    J Biol Chem  2014;289:9952
  80. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
    Authors: Wu Et al.
    Fibrogenesis Tissue Repair  2014;289:20193
  81. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li Et al.
    Cell Signal  2014;26:1369
  82. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
    Authors: Fang Et al.
    J Pharm Sci Pharmacol  2014;1:175
  83. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
    Authors: Soares Et al.
    Cell Stem Cell  2014;173:53
  84. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  85. The development of zebrafish tendon and ligament progenitors.
    Authors: Chen
    Development  2014;141:2035
  86. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    J Cell Sci  2014;111:18126
  87. Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
    Authors: Razak Et al.
    Nat Neurosci  2013;8:e73532
  88. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  89. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
    Authors: Lotz Et al.
    PLoS One  2013;8:e56289
  90. A novel model of dormancy for bone metastatic breast cancer cells.
    Authors: Marlow Et al.
    Cancer Res  2013;73:6886
  91. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Authors: Briones-Orta Et al.
    Am J Stem Cells  2013;73:1800
  92. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front.Cell Neurosci.  2013;6:64
  93. The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Authors: Woodruff Et al.
    Cell Rep  2013;5:974
  94. Translating dosage compensation to trisomy 21.
    Authors: Jiang Et al.
    Nature  2013;500:296
  95. High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;3:2296
  96. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Authors: Kreitzer Et al.
    Nat Methods  2013;2:119
  97. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    Authors: Spender Et al.
    J Biol Chem  2013;288:5198
  98. Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
    Authors: Honda Et al.
    ACS Chem Neurosci  2013;288:26157
  99. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res  2013;247:694
  100. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Authors: Davila Et al.
    J Neurosci Methods  2013;216:104
  101. Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.
    Authors: Lee-Chang Et al.
    J Immunol  2013;191:4141
  102. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas and
    Nat Neurosci  2013;16:1773
  103. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther  2013;14:638
  104. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
    Authors: Rafiei and Komarova
    BMC Cancer  2013;13:605
  105. TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.
    Authors: McQualter Et al.
    Stem Cell Res  2013;11:1222
  106. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    PLoS One  2013;11:1206
  107. Snail cooperates with KrasG12D to promote pancreatic fibrosis.
    Authors: Shields Et al.
    Mol Cancer Res  2013;11:1078
  108. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
    Authors: Shalom-Feuerstein Et al.
    Neuropsychopharmacology  2013;110:2152
  109. Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.
    Authors: Kusuma Et al.
    Antimicrob Agents Chemother  2013;110:12601
  110. A simple tool to improve pluripotent stem cell differentiation.
    Authors: Chetty Et al.
    Cell  2013;10:553
  111. High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
    Authors: Outten Et al.
    Curr Protoc Stem Cell Biol  2012;Chapter 1:Unit 1D.6
  112. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    Nat Biotechnol  2012;7:e49079
  113. TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
    Authors: Sohni Et al.
    PLoS One  2012;7:e47629
  114. Transposon-mediated BAC transgenesis in human ES cells.
    Authors: Rostovskaya Et al.
    Nucleic Acids Res  2012;40:e150
  115. A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells.
    Authors: Smith Et al.
    PLoS One  2012;3:518
  116. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A  2012;3:482
  117. Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
    Authors: Grönroos Et al.
    Mol Cell Biol  2012;32:2904
  118. Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
    Authors: Denham Et al.
    J Neurosci  2012;30:2400
  119. TGF-β blockade does not improve control of an established persistent viral infection.
    Authors: Boettler Et al.
    Viral Immunol  2012;25:232
  120. Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
    Authors: Mak Et al.
    Stem Cells Int  2012;2012:140427
  121. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    Authors: Shi Et al.
    Cancer Res  2012;15:477
  122. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
    Authors: Patsialou Et al.
    Breast Cancer Res  2012;14:R139
  123. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.
    Authors: Boeuf Et al.
    BMC Cancer  2012;12:488
  124. Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
    Authors: Varela Et al.
    Sci Rep  2012;122:569
  125. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
    Authors: Valdez Et al.
    Nature  2012;11:676
  126. Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
    Authors: Luo and Su
    PLoS Biol  2012;10:e1001402
  127. Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells.
    Authors: Hoda Et al.
    Br J Cancer  2012;107:1978
  128. Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
    Authors: Xie Et al.
    Proc Natl Acad Sci U S A  2011;Suppl 1
  129. Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling.
    Authors: Kurita and Wada
    Biol Lett  2011;7:759
  130. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T-regulatory cells.
    Authors: Olkhanud Et al.
    Cancer Res  2011;71:3505
  131. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
    Authors: Bedel Et al.
    Cancer Res  2011;71:1615
  132. Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
    Authors: Wilson Et al.
    PLoS One  2011;6:e22842
  133. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
    Authors: Tan Et al.
    Nat Cell Biol  2011;6:e17124
  134. Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.
    Authors: Herman-Edelstein Et al.
    Diabetes  2011;60:1779
  135. Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
    Authors: Chen Et al.
    PLoS One  2011;4:9
  136. Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
    Authors: Duan Et al.
    J Clin Cell Immunol  2011;36:54
  137. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
    Authors: Seibler Et al.
    Shock  2011;31:5970
  138. Reversible differentiation of myofibroblasts by MyoD.
    Authors: Hecker Et al.
    PLoS One  2011;317:1914
  139. Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression.
    Authors: Dangi-Garimella Et al.
    Oncogene  2011;30:1002
  140. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
    Authors: Grocott Et al.
    Stem Cell Reports  2011;2:265
  141. Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.
    Authors: Holley Et al.
    J Biol Chem  2011;286:6241
  142. Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
    Authors: Shields Et al.
    J Biol Chem  2011;286:10495
  143. β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
    Authors: Paek Et al.
    Dev Cell  2011;20:689
  144. A poised chromatin platform for TGF-β access to master regulators.
    Authors: Xi Et al.
    Biochem Biophys Res Commun  2011;147:1511
  145. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
    Authors: Ewan Et al.
    Cancer Res  2010;70:5963
  146. Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
    Authors: Redondo Et al.
    PLoS One  2010;5:e9800
  147. Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.
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endothelial differentiation
By Anonymous on 05/01/2018
Species: Human

Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)


Works great.
By Anonymous on 01/04/2018
Species: Human

I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.


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