SB 431542

Catalog # Availability Size / Price Qty
1614/10
1614/1
1614/50
TGF-beta Receptor Inhibitors Small Molecule
1 Image
Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Purity: ≥99%

Product Details
Citations (240)
Supplemental Products
Reviews (2)

Biological Activity

Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

Technical Data

M.Wt:
384.39
Formula:
C22H16N4O3
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
301836-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SB 431542

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

240 Citations: Showing 1 - 10

  1. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart.
    Authors: Bise Et al.
    NPJ Regen Med  2019;4:2
  2. Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
    Authors: Sharma Et al.
    Arterioscler Thromb Vasc Biol  2019;39:212
  3. Long-term functional maintenance of primary human hepatocytes in vitro.
    Authors: Xiang Et al.
    Science  2019;364:399
  4. A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
    Authors: Serrano Et al.
    Stem Cells Dev  2019;28:81
  5. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
    Authors: Paonessa Et al.
    Cell Rep  2019;26:582
  6. Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
    Authors: Lang Et al.
    Cell Stem Cell  2019;24:93
  7. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches.
    Authors: Varghese Et al.
    Stem Cells Int  2019;2019:5968236
  8. Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
    Authors: Nguyen Et al.
    Stem Cells Int  2019;2019:3298432
  9. Reliability of human cortical organoid generation.
    Authors: Yoon Et al.
    Nat Methods  2019;16:75
  10. The Spatiotemporal Control of Zygotic Genome Activation.
    Authors: Gentsch Et al.
    iScience  2019;16:485
  11. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
    Authors: Haidar Et al.
    Autophagy  2019;15:1051
  12. Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.
    Authors: Aquino-Martínez Et al.
    PLoS One  2019;14:e0210301
  13. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
    Authors: Yin Et al.
    Stem Cell Reports  2019;12:488
  14. Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
    Authors: Easterbrook Et al.
    Stem Cell Reports  2019;12:1056
  15. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  16. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  17. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  18. Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
    Authors: Yang Et al.
    Sci Rep  2018;8:8495
  19. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
    Authors: Bayo-Puxan Et al.
    Sci Rep  2018;8:16644
  20. Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling.
    Authors: Subramanian Et al.
    Elife  2018;7
  21. Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
    Authors: Hsu Et al.
    Elife  2018;7
  22. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
    Authors: Smyth Et al.
    Int J Parasitol  2018;48:379
  23. Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
    Authors: Bernard Et al.
    J Biol Chem  2018;293:1218
  24. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
    Authors: Wang
    Nat Med  2018;24(5):647
  25. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
    Authors: Nehme Et al.
    Cell Rep  2018;23:2509
  26. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  27. Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
    Authors: Wu Et al.
    Cell  2018;172:423
  28. MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo.
    Authors: Molina Et al.
    PLoS Genet  2018;14:e1007621
  29. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
    Authors: Raykhel Et al.
    J Cell Sci  2018;131
  30. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
    Authors: Li Et al.
    Stem Cell Reports  2018;11:998
  31. Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
    Authors: Fr?hlich Et al.
    Front Mol Neurosci  2018;11:81
  32. TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
    Authors: Albers Et al.
    Int J Stem Cells  2018;11:111
  33. Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
    Authors: Medelnik Et al.
    Stem Cell Reports  2018;10:1751
  34. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
    Authors: Sloan Et al.
    Neuron  2017;95:779
  35. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    Authors: Offermann Et al.
    Oncotarget  2017;8:7964
  36. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  37. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
    Authors: Christoforou Et al.
    Sci Rep  2017;7:40285
  38. Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
    Authors: Kunnen Et al.
    Cell Mol Life Sci  2017;74:2283
  39. Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
    Authors: Song Et al.
    Mol Cell  2017;67:148
  40. Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory.
    Authors: Park Et al.
    Elife  2017;6
  41. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
    Authors: Takata Et al.
    Immunity  2017;47:183
  42. Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
    Authors: Charney Et al.
    Dev Cell  2017;40:595
  43. Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
    Authors: Yang Et al.
    Cell Mol Gastroenterol Hepatol  2017;3:484
  44. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
    Authors: Major Et al.
    Curr Protoc Stem Cell Biol  2017;39:1H.10.1
  45. Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer.
    Authors: Funaki Et al.
    Oncol Rep  2017;38:2277
  46. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
    Authors: Ruetz Et al.
    Cell Stem Cell  2017;21:791
  47. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  48. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  49. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
    Authors: McCauley Et al.
    Cell Stem Cell  2017;20:844
  50. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
    Authors: Saini Et al.
    Cell Stem Cell  2017;20:635
  51. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
    Authors: Bershteyn Et al.
    Cell Stem Cell  2017;20:435
  52. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  53. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC Cancer  2017;17(1):202
  54. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  55. p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
    Authors: Molina Et al.
    Development  2017;144:2270
  56. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
    Authors: Sampaziotis Et al.
    Nat Protoc  2017;12:814
  57. Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
    Authors: Bao Et al.
    Nat Protoc  2017;12:1890
  58. Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.
    Authors: Guo Et al.
    Biomaterials  2017;122:179
  59. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  60. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells  2016;8:e65580
  61. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
    Authors: Spender Et al.
    Oncotarget  2016;7:81995
  62. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy  2016;7:174
  63. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  64. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc  2016;6:21518
  65. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2016;6:19727
  66. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol  2016;6:19533
  67. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer.
    Authors: Buczek Et al.
    Oncogene  2016;35:3465
  68. Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
    Authors: Genbacev Et al.
    Hum Reprod  2016;31:1300
  69. Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
    Authors: Topalovski Et al.
    J Biol Chem  2016;291:22244
  70. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421
  71. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  72. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  73. AVNA programs the differentiation of human TFH cells.
    Authors: Locci Et al.
    Nat Immunol  2016;17:976
  74. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  75. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
    Authors: Maturana Et al.
    J Neuroinflammation  2016;13:295
  76. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens  2016;12:e1005991
  77. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One  2016;11:e0165497
  78. Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.
    Authors: Ghaedi and Niklason
    Methods Mol Biol  2016;
  79. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep  2015;89:5134
  80. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  81. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol  2015;6:8896
  82. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun  2015;6:7264
  83. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest  2015;6:5
  84. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther  2015;6:125
  85. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol  2015;63:420
  86. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer  2015;61:42626
  87. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol  2015;5:660
  88. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev  2015;5:323
  89. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo  2015;5:16872
  90. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol  2015;5:11252
  91. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest  2015;5:1010
  92. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One  2015;52:1850
  93. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest  2015;400:129
  94. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  95. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev  2015;3:e1486
  96. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med  2015;330:29
  97. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet  2015;26:205
  98. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun  2015;263:190
  99. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports  2015;24:5260
  100. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol  2015;24:2591
  101. Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain  2015;21:276
  102. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  103. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol  2015;17:615
  104. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  105. The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway.
    Authors: Wilson Et al.
    Sci Rep  2015;15:55
  106. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports  2015;142:3166
  107. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  108. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  109. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep  2015;125:3008
  110. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol  2015;125:2032
  111. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell  2015;11:e1004453
  112. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ  2015;10:e0125590
  113. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  114. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One  2015;10:e0116995
  115. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res  2015;10:413
  116. Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
    Authors: Ginsberg Et al.
    Nat Protoc  2015;10:1975
  117. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One  2014;9:e91269
  118. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis  2014;70:12
  119. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One  2014;4:7323
  120. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med  2014;3:1169
  121. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for DA Neurons From Human Pluripotent Stem Cells.
    Authors: Aguila Et al.
    Stem Cells Transl Med  2014;3:1032
  122. miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Authors: Rosa Et al.
    Dev Biol  2014;391:81
  123. Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
    Authors: Magaña Et al.
    Dev Biol  2014;387:15
  124. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
    Authors: Curado Et al.
    Exp Neurol  2014;34:4389
  125. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
    Authors: Orlova Et al.
    Arterioscler Thromb Vasc Biol  2014;34:177
  126. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  127. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    Authors: O'Reilly Et al.
    J Biol Chem  2014;289:9952
  128. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
    Authors: Wu Et al.
    Fibrogenesis Tissue Repair  2014;289:20193
  129. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li Et al.
    Cell Signal  2014;26:1369
  130. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
    Authors: Fang Et al.
    J Pharm Sci Pharmacol  2014;1:175
  131. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
    Authors: Soares Et al.
    Cell Stem Cell  2014;173:53
  132. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  133. The development of zebrafish tendon and ligament progenitors.
    Authors: Chen
    Development  2014;141:2035
  134. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    J Cell Sci  2014;111:18126
  135. Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
    Authors: Razak Et al.
    Nat Neurosci  2013;8:e73532
  136. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  137. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
    Authors: Lotz Et al.
    PLoS One  2013;8:e56289
  138. A novel model of dormancy for bone metastatic breast cancer cells.
    Authors: Marlow Et al.
    Cancer Res  2013;73:6886
  139. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Authors: Briones-Orta Et al.
    Am J Stem Cells  2013;73:1800
  140. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front.Cell Neurosci.  2013;6:64
  141. The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Authors: Woodruff Et al.
    Cell Rep  2013;5:974
  142. Translating dosage compensation to trisomy 21.
    Authors: Jiang Et al.
    Nature  2013;500:296
  143. High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;3:2296
  144. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Authors: Kreitzer Et al.
    Nat Methods  2013;2:119
  145. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    Authors: Spender Et al.
    J Biol Chem  2013;288:5198
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endothelial differentiation
By Anonymous on 05/01/2018
Species: Human

Stems cells undergoing differentiation to endothelial cells utilize addition of SB 431542. FLK+ve cells cultured with SB 431542 revealed colonies of endothelial cells (arrows)


Works great.
By Anonymous on 01/04/2018
Species: Human

I used this product for differentiation of iPSCs into dopaminergic neurons according to the protocol published in Kriks et al, 2011.I used the concentration 10uM and it works really well.


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