SB 431542

Long-term functional maintenance of primary human hepatocytes in vitro.
Authors: Xiang Et al.
Science  2019;364:399

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
Authors: Serrano Et al.
Stem Cells Dev  2019;28:81

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Authors: Paonessa Et al.
Cell Rep  2019;26:582

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
Authors: Colunga Et al.
Cell Rep  2019;26:2566

Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome.
Authors: Balbi Et al.
Data Brief  2019;25:104324

Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Authors: Lang Et al.
Cell Stem Cell  2019;24:93

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
Authors: Montel-Hagen Et al.
Cell Stem Cell  2019;24:376

Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches.
Authors: Varghese Et al.
Stem Cells Int  2019;2019:5968236

Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
Authors: Nguyen Et al.
Stem Cells Int  2019;2019:3298432

Reliability of human cortical organoid generation.
Authors: Yoon Et al.
Nat Methods  2019;16:75

The Spatiotemporal Control of Zygotic Genome Activation.
Authors: Gentsch Et al.
iScience  2019;16:485

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.
Authors: Canfield Et al.
Fluids Barriers CNS  2019;16:25

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
Authors: Haidar Et al.
Autophagy  2019;15:1051

A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology.
Authors: Yoshimatsu Et al.
PLoS One  2019;14:e0221164

Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.
Authors: Aquino-Martínez Et al.
PLoS One  2019;14:e0210301

Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Authors: Garcia Et al.
Front Neurosci  2019;13:669

Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
Authors: Yin Et al.
Stem Cell Reports  2019;12:488

Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
Authors: Easterbrook Et al.
Stem Cell Reports  2019;12:1056

Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals.
Authors: Gentsch Et al.
Nat Commun  2019;10:4269

Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
Authors: Caron Et al.
Stem Cell Res Ther  2019;10:221

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun  2018;9:4047

Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
Authors: Magro-Lopez Et al.
Stem Cell Res.Ther.  2018;9:186

Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Authors: Caires-J?nior
Nat Commun  2018;9(1):475

Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
Authors: Yang Et al.
Sci Rep  2018;8:8495

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Authors: Bayo-Puxan Et al.
Sci Rep  2018;8:16644

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
Authors: Hsu Et al.
Elife  2018;7

Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling.
Authors: Subramanian Et al.
Elife  2018;7

TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
Authors: Smyth Et al.
Int J Parasitol  2018;48:379

Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
Authors: McCauley Et al.
Curr Protoc Stem Cell Biol  2018;45:e51

Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Authors: Noskovičová Et al.
Am J Physiol Lung Cell Mol Physiol  2018;314:L695

Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
Authors: Bernard Et al.
J Biol Chem  2018;293:1218

Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
Authors: Mehta Et al.
Cell Rep  2018;25:1081

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Authors: Wang
Nat Med  2018;24(5):647

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
Authors: Nehme Et al.
Cell Rep  2018;23:2509

Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
Authors: Sommer Et al.
Cell Stem Cell.  2018;23:123

The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.
Authors: Tebbenkamp Et al.
Cell  2018;175:1088

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Authors: Wu Et al.
Cell  2018;172:423

MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo.
Authors: Molina Et al.
PLoS Genet  2018;14:e1007621

Generation and assembly of human brain region-specific three-dimensional cultures.
Authors: Sloan Et al.
Nat Protoc  2018;13:2062

BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
Authors: Raykhel Et al.
J Cell Sci  2018;131

Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
Authors: Li Et al.
Stem Cell Reports  2018;11:998

Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
Authors: Fr?hlich Et al.
Front Mol Neurosci  2018;11:81

TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
Authors: Albers Et al.
Int J Stem Cells  2018;11:111

Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
Authors: Medelnik Et al.
Stem Cell Reports  2018;10:1751

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Authors: Sloan Et al.
Neuron  2017;95:779

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
Authors: Offermann Et al.
Oncotarget  2017;8:7964

Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
Authors: Subramanian Et al.
Nat Commun  2017;8:14167

Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
Authors: Christoforou Et al.
Sci Rep  2017;7:40285

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Authors: Kunnen Et al.
Cell Mol Life Sci  2017;74:2283

Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
Authors: Song Et al.
Mol Cell  2017;67:148

Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory.
Authors: Park Et al.
Elife  2017;6

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
Authors: Takata Et al.
Immunity  2017;47:183

Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
Authors: Charney Et al.
Dev Cell  2017;40:595

Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
Authors: Yang Et al.
Cell Mol Gastroenterol Hepatol  2017;3:484

Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
Authors: Major Et al.
Curr Protoc Stem Cell Biol  2017;39:1H.10.1

Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer.
Authors: Funaki Et al.
Oncol Rep  2017;38:2277

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
Authors: Ruetz Et al.
Cell Stem Cell  2017;21:791

Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
Authors: Kotton Et al.
Cell Stem Cell.  2017;21:472

A modular platform for differentiation of human PSCs into all major ectodermal lineages.
Authors: Tchieu Et al.
Cell Stem Cell  2017;21:399

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
Authors: McCauley Et al.
Cell Stem Cell  2017;20:844

Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
Authors: Saini Et al.
Cell Stem Cell  2017;20:635

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
Authors: Bershteyn Et al.
Cell Stem Cell  2017;20:435

In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
Authors: Xi
Cell Rep  2017;18(6):1573

Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
Authors: de la Mare
BMC Cancer  2017;17(1):202

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Authors: Yang Et al.
Cell  2017;169:243

p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
Authors: Molina Et al.
Development  2017;144:2270

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
Authors: Sampaziotis Et al.
Nat Protoc  2017;12:814

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
Authors: Bao Et al.
Nat Protoc  2017;12:1890

Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.
Authors: Guo Et al.
Biomaterials  2017;122:179

The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
Authors: Young
Proc Natl Acad Sci U S A.  2017;114(28):E5599

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
Authors: Oenema Et al.
Stem Cells  2016;8:e65580

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
Authors: Spender Et al.
Oncotarget  2016;7:81995

Human fetal and adult epicardial-derived cells: a novel model to study their activation
Authors: Moerkamp Et al.
Stem Cell Research & Therapy  2016;7:174

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Authors: Kapeli Et al.
Nature Communications  2016;7:12143

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
Authors: Vargel Et al.
Nat Protoc  2016;6:21518

Generating trunk neural crest from human pluripotent stem cells.
Authors: Huang Et al.
Sci Rep  2016;6:19727

The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling.
Authors: Morris Et al.
Mol Cell Biol  2016;6:19533

Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer.
Authors: Buczek Et al.
Oncogene  2016;35:3465

Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
Authors: Genbacev Et al.
Hum Reprod  2016;31:1300

Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
Authors: Topalovski Et al.
J Biol Chem  2016;291:22244

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Authors: Zeltner Et al.
Nat Med  2016;22:1421

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell  2016;19:217

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
Authors: Nott Et al.
Nat Neurosci  2016;19:1497

AVNA programs the differentiation of human TFH cells.
Authors: Locci Et al.
Nat Immunol  2016;17:976

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
Authors: Manno Et al.
Cell  2016;167:566

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
Authors: Maturana Et al.
J Neuroinflammation  2016;13:295

A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
Authors: Sulaiman Et al.
PLoS Pathogens  2016;12:e1005991

Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
Authors: Marro Et al.
PLoS One  2016;11:e0165497

Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.
Authors: Ghaedi and Niklason
Methods Mol Biol  2016;

Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
Authors: Tabata Et al.
Sci Rep  2015;89:5134

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Authors: Rempel Et al.
Arch Toxicol  2015;89:1599

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
Authors: Sakaguchi Et al.
Mol Neurobiol  2015;6:8896

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Authors: Aspalter Et al.
Nat Commun  2015;6:7264

The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
Authors: Soukup Et al.
J Clin Invest  2015;6:5

Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
Authors: Oh Et al.
Stem Cell Res Ther  2015;6:125

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
Authors: Yan Et al.
J Hepatol  2015;63:420

Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
Authors: Honsho Et al.
BMC Cancer  2015;61:42626

Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
Authors: Agu Et al.
Exp Neurol  2015;5:660

Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
Authors: Singh Et al.
Stem Cells Dev  2015;5:323

Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
Authors: Ramnath Et al.
Evodevo  2015;5:16872

A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
Authors: Caraci Et al.
PLoS Comput Biol  2015;5:11252

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
Authors: Imaizumi Et al.
J Clin Invest  2015;5:1010

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
Authors: Ooi Et al.
PLoS One  2015;52:1850

TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
Authors: Martínez-Armenta Et al.
J Clin Invest  2015;400:129

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
Authors: Kumar Et al.
Elife  2015;4

Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
Authors: Lages Et al.
J Reprod Dev  2015;3:e1486

TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
Authors: Bras Et al.
Mol Med  2015;330:29

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
Authors: Niederst Et al.
Hum Mol Genet  2015;26:205

Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
Authors: Saporta Et al.
Nat Commun  2015;263:190

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
Authors: Sposito Et al.
Stem Cell Reports  2015;24:5260

Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
Authors: Hu Et al.
J Virol  2015;24:2591

Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
Authors: Chen Et al.
Brain  2015;21:276

Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
Authors: Zhang Et al.
Cell Stem Cell  2015;17:735

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
Authors: Cebola Et al.
Mol Cell Endocrinol  2015;17:615

Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
Authors: Piao Et al.
Cell Stem Cell  2015;16:198

The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway.
Authors: Wilson Et al.
Sci Rep  2015;15:55

Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
Authors: Jönsson Et al.
Stem Cell Reports  2015;142:3166

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
Authors: Iovino Et al.
Development  2015;138:3345

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Authors: Pasca Et al.
Nat Methods  2015;12:671

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
Authors: Li Et al.
Sci Rep  2015;125:3008

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
Authors: Hadland Et al.
Nat Cell Biol  2015;125:2032

Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
Authors: Ziv Et al.
Mol Biol Cell  2015;11:e1004453

TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
Authors: Kawahara Et al.
PeerJ  2015;10:e0125590

Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
Authors: Woods Et al.
PLoS One  2015;10:e0123641

SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
Authors: Sanders Et al.
PLoS One  2015;10:e0116995

The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang Et al.
Exp Cell Res  2015;10:413

Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
Authors: Ginsberg Et al.
Nat Protoc  2015;10:1975

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
Authors: Nishimura Et al.
PLoS One  2014;9:e91269

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
Authors: Grunseich Et al.
Neurobiol Dis  2014;70:12

Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
Authors: Dai Et al.
PLoS One  2014;4:7323

Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
Authors: Domev Et al.
Stem Cells Transl Med  2014;3:1169

Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for DA Neurons From Human Pluripotent Stem Cells.
Authors: Aguila Et al.
Stem Cells Transl Med  2014;3:1032

miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
Authors: Rosa Et al.
Dev Biol  2014;391:81

Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
Authors: Magaña Et al.
Dev Biol  2014;387:15

ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
Authors: Curado Et al.
Exp Neurol  2014;34:4389

Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
Authors: Orlova Et al.
Arterioscler Thromb Vasc Biol  2014;34:177

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Authors: Huang Et al.
Nat Biotechnol  2014;32:84

Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
Authors: O'Reilly Et al.
J Biol Chem  2014;289:9952

A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
Authors: Wu Et al.
Fibrogenesis Tissue Repair  2014;289:20193

PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
Authors: Li Et al.
Cell Signal  2014;26:1369

Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
Authors: Fang Et al.
J Pharm Sci Pharmacol  2014;1:175

Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
Authors: Soares Et al.
Cell Stem Cell  2014;173:53

TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Authors: Babu Et al.
BMC Cancer  2014;14:113

The development of zebrafish tendon and ligament progenitors.
Authors: Chen
Development  2014;141:2035

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
Authors: Wrighton Et al.
J Cell Sci  2014;111:18126

Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
Authors: Razak Et al.
Nat Neurosci  2013;8:e73532

EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
Authors: Voon Et al.
PLoS One  2013;8:e70427

Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
Authors: Lotz Et al.
PLoS One  2013;8:e56289

A novel model of dormancy for bone metastatic breast cancer cells.
Authors: Marlow Et al.
Cancer Res  2013;73:6886

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
Authors: Briones-Orta Et al.
Am J Stem Cells  2013;73:1800

Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
Authors: Kirkeby Et al.
Front.Cell Neurosci.  2013;6:64

The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
Authors: Woodruff Et al.
Cell Rep  2013;5:974

Translating dosage compensation to trisomy 21.
Authors: Jiang Et al.
Nature  2013;500:296

High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
Authors: Kim Et al.
Proc Natl Acad Sci U S A  2013;3:2296

A robust method to derive functional neural crest cells from human pluripotent stem cells.
Authors: Kreitzer Et al.
Nat Methods  2013;2:119

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
Authors: Spender Et al.
J Biol Chem  2013;288:5198

Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
Authors: Honda Et al.
ACS Chem Neurosci  2013;288:26157

Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
Authors: Pol Et al.
Stem Cell Res  2013;247:694

Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
Authors: Davila Et al.
J Neurosci Methods  2013;216:104

Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.
Authors: Lee-Chang Et al.
J Immunol  2013;191:4141

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
Authors: Bialas and
Nat Neurosci  2013;16:1773

Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther  2013;14:638

Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
Authors: Rafiei and Komarova
BMC Cancer  2013;13:605

TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.
Authors: McQualter Et al.
Stem Cell Res  2013;11:1222

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
Authors: Crompton Et al.
PLoS One  2013;11:1206

Snail cooperates with KrasG12D to promote pancreatic fibrosis.
Authors: Shields Et al.
Mol Cancer Res  2013;11:1078

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
Authors: Shalom-Feuerstein Et al.
Neuropsychopharmacology  2013;110:2152

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.
Authors: Kusuma Et al.
Antimicrob Agents Chemother  2013;110:12601

A simple tool to improve pluripotent stem cell differentiation.
Authors: Chetty Et al.
Cell  2013;10:553

High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
Authors: Outten Et al.
Curr Protoc Stem Cell Biol  2012;Chapter 1:Unit 1D.6

Modulation of pluripotency in the porcine embryo and iPS cells.
Authors: Rodríguez Et al.
Nat Biotechnol  2012;7:e49079

TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
Authors: Sohni Et al.
PLoS One  2012;7:e47629

Transposon-mediated BAC transgenesis in human ES cells.
Authors: Rostovskaya Et al.
Nucleic Acids Res  2012;40:e150

A novel co-operative mechanism linking TGFβ and Lyn kinase activation to Im.nib resistance in chronic myeloid leukaemia cells.
Authors: Smith Et al.
PLoS One  2012;3:518

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
Authors: Neely Et al.
Proc Natl Acad Sci U S A  2012;3:482

Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
Authors: Grönroos Et al.
Mol Cell Biol  2012;32:2904

Glycogen synthase kinase 3β and act./nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
Authors: Denham Et al.
J Neurosci  2012;30:2400

TGF-β blockade does not improve control of an established persistent viral infection.
Authors: Boettler Et al.
Viral Immunol  2012;25:232

Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
Authors: Mak Et al.
Stem Cells Int  2012;2012:140427

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
Authors: Shi Et al.
Cancer Res  2012;15:477

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
Authors: Patsialou Et al.
Breast Cancer Res  2012;14:R139

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.
Authors: Boeuf Et al.
BMC Cancer  2012;12:488

Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
Authors: Varela Et al.
Sci Rep  2012;122:569

Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
Authors: Valdez Et al.
Nature  2012;11:676

Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
Authors: Luo and Su
PLoS Biol  2012;10:e1001402

Suppression of AVNA signals inhibits growth of malignant pleural mesothelioma cells.
Authors: Hoda Et al.
Br J Cancer  2012;107:1978

Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
Authors: Xie Et al.
Proc Natl Acad Sci U S A  2011;Suppl 1

Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling.
Authors: Kurita and Wada
Biol Lett  2011;7:759

Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cells.
Authors: Olkhanud Et al.
Cancer Res  2011;71:3505

Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
Authors: Bedel Et al.
Cancer Res  2011;71:1615

Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
Authors: Wilson Et al.
PLoS One  2011;6:e22842

Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
Authors: Tan Et al.
Nat Cell Biol  2011;6:e17124

Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.
Authors: Herman-Edelstein Et al.
Diabetes  2011;60:1779

Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
Authors: Chen Et al.
PLoS One  2011;4:9

Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
Authors: Duan Et al.
J Clin Cell Immunol  2011;36:54

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
Authors: Seibler Et al.
Shock  2011;31:5970

Reversible differentiation of myofibroblasts by MyoD.
Authors: Hecker Et al.
PLoS One  2011;317:1914

Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression.
Authors: Dangi-Garimella Et al.
Oncogene  2011;30:1002

Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
Authors: Grocott Et al.
Stem Cell Reports  2011;2:265

Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble Hep. and heparan sulfate saccharides.
Authors: Holley Et al.
J Biol Chem  2011;286:6241

Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
Authors: Shields Et al.
J Biol Chem  2011;286:10495

β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
Authors: Paek Et al.
Dev Cell  2011;20:689

A poised chromatin platform for TGF-β access to master regulators.
Authors: Xi Et al.
Biochem Biophys Res Commun  2011;147:1511

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Authors: Ewan Et al.
Cancer Res  2010;70:5963

Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
Authors: Redondo Et al.
PLoS One  2010;5:e9800

Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.
Authors: Krueger
PLoS One  2010;5:e15511

Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes.
Authors: Wang Et al.
Nat Commun  2010;4:15

Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
Authors: Ishida Et al.
Dev Biol  2010;340:468

Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent.
Authors: James Et al.
Nat Biotechnol  2010;28:161

Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.
Authors: Fong Et al.
J Biol Chem  2010;285:31427

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
Authors: Moyano Et al.
Mol Biol Cell  2010;21:3654

Pig epiblast stem cells depend on act./nodal signaling for pluripotency and self-renewal.
Authors: Alberio Et al.
Stem Cells Dev  2010;19:1627

PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.
Authors: Ham Et al.
J Cell Mol Med  2010;14:1747

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
Authors: Hannigan Et al.
J Clin Invest  2010;120:2842

Extracellular matrix-induced gene expression in human breast cancer cells.
Authors: Garamszegi Et al.
Mol Cancer Res  2009;7:319

Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
Authors: Patsialou Et al.
Cancer Res  2009;69:9498

Pharmacological inhibition of transforming growth factor β signaling decreases infection and prevents heart damage in acute Chagas' disease.
Authors: Waghabi Et al.
Sci Rep  2009;53:4694

SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.
Authors: Xiao Et al.
Invest Ophthalmol Vis Sci  2009;50:1698

act./Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
Authors: Patani Et al.
Oncotarget  2009;4:e7327

TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature.
Authors: Walshe Et al.
PLoS One  2009;4:e5149

Nodal signalling is involved in left-right asymmetry in snails.
Authors: Grande and Patel
J Cell Commun Signal  2009;457:1007

Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
Authors: Cacheaux Et al.
J Neurosci  2009;29:8927

Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics.
Authors: Clarke Et al.
Mol Cell Biol  2009;29:2443

Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
Authors: Li Et al.
Stem Cells  2009;27:2992

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
Authors: Chambers Et al.
J Biotechnol  2009;27:275

Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei.
Authors: Roussigne Et al.
Development  2009;136:1549

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility.
Authors: Giampieri Et al.
J Biol Chem  2009;11:1287

Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.
Authors: Bharathy Et al.
Cancer Res  2008;68:1656

Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-α.
Authors: Ding and Warburton
Hypertens Res  2008;375:460

TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
Authors: Ho and Whitman
Dev Biol  2008;315:203

Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression.
Authors: Yang Et al.
Oncogene  2008;27:5326

A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization.
Authors: Stoikos Et al.
Hum Reprod  2008;23:1447

Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor.
Authors: Gressner Et al.
J Cell Mol Med  2008;12:2717

Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Authors: Zhang Et al.
Blood  2008;111:1933

Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells.
Authors: Montesano Et al.
BMC Dev Biol  2007;7:7

The role of maternal act.-like signals in zebrafish embryos.
Authors: Hagos Et al.
Dev Biol  2007;309:245

Transforming growth factor: beta signaling is essential for limb regeneration in axolotls.
Authors: L&eacutevesque Et al.
PLoS One  2007;2:e1227

AVNacutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I.
Authors: Zhu Et al.
J Neurosci  2007;27:13770

Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
Authors: Horowitz Et al.
Cell Signal  2007;19:761

Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules.
Authors: Dai Et al.
Mol Biol Cell  2007;18:2264

TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.
Authors: Ivens Et al.
Brain  2007;130:535

Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation.
Authors: Castañares Et al.
Genes Dev  2007;120:1256

PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
Authors: Zhao Et al.
Biochem Biophys Res Commun  2006;350:385

Transforming growth factor-β signaling enhances transdifferentiation of macrophages into smooth muscle-like cells.
Authors: Ninomiya Et al.
Mol Cell Biol  2006;29:269

Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
Authors: Ho Et al.
Dev Biol  2006;295:730

Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Authors: Shi-Wen Et al.
Exp Cell Res  2006;26:5518

Identification of phosphatases for Smad in the BMP/DPP pathway.
Authors: Chen Et al.
Sci Rep  2006;20:648

Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells.
Authors: Anumanthan Et al.
Br J Cancer  2005;93:1157

TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling.
Authors: König Et al.
J Cell Biol  2005;168:1077

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/act.-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
Authors: Chen Et al.
Am J Pathol  2005;167:1699

Tra.Mab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma.
Authors: Mimura Et al.
Clin Cancer Res  2005;11:4898