Catalog Number: 1614
Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Biological Activity
Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542.
    Laping et al.
    Mol.Pharmacol., 2002;62:58
  2. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
    Inman et al.
    Mol.Pharmacol., 2002;62:65
  3. SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells.
    Matsuyama et al.
    Cancer Res., 2003;63:7791
  4. TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.
    Watabe et al.
    J.Cell Biol., 2003;163:163
  5. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.
    Halder et al.
    Neoplasia, 2005;7:509

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

142 Citations: Showing 1 - 10
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  1. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell. 2017;21:472
  2. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell 2017;21:399
  3. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep 2017;18(6):1573
  4. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC?Cancer 2017;17(1):202
  5. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells 2016;8:e65580
  6. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy 2016;7:174
  7. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications 2016;7:12143
  8. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc 2016;6:21518
  9. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep 2016;6:19727
  10. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol 2016;6:19533
  11. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell 2016;19:217
  12. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens 2016;12:e1005991
  13. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One 2016;11:e0165497
  14. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep 2015;89:5134
  15. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol 2015;6:8896
  16. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun 2015;6:7264
  17. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest 2015;6:5
  18. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther 2015;6:125
  19. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol 2015;63:420
  20. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer 2015;61:42626
  21. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol 2015;5:660
  22. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev 2015;5:323
  23. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo 2015;5:16872
  24. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol 2015;5:11252
  25. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest 2015;5:1010
  26. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One 2015;52:1850
  27. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest 2015;400:129
  28. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife 2015;4
  29. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev 2015;3:e1486
  30. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med 2015;330:29
  31. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet 2015;26:205
  32. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun 2015;263:190
  33. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports 2015;24:5260
  34. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol 2015;24:2591
  35. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain 2015;21:276
  36. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol 2015;17:615
  37. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell 2015;16:198
  38. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Authors: Wilson Et al.
    Sci Rep 2015;15:55
  39. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports 2015;142:3166
  40. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development 2015;138:3345
  41. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods 2015;12:671
  42. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep 2015;125:3008
  43. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol 2015;125:2032
  44. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell 2015;11:e1004453
  45. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ 2015;10:e0125590
  46. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One 2015;10:e0123641
  47. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One 2015;10:e0116995
  48. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res 2015;10:413
  49. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One 2014;9:e91269
  50. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis 2014;70:12
  51. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One 2014;4:7323
  52. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med 2014;3:1169
  53. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.
    Authors: Aguila Et al.
    Stem Cells Transl Med 2014;3:1032
  54. miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Authors: Rosa Et al.
    Dev Biol 2014;391:81
  55. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
    Authors: Curado Et al.
    Exp Neurol 2014;34:4389
  56. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol 2014;32:84
  57. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
    Authors: Wu Et al.
    Fibrogenesis Tissue Repair 2014;289:20193
  58. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
    Authors: Fang Et al.
    J Pharm Sci Pharmacol 2014;1:175
  59. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
    Authors: Soares Et al.
    Cell Stem Cell 2014;173:53
  60. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer 2014;14:113
  61. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    J Cell Sci 2014;111:18126
  62. Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
    Authors: Razak Et al.
    Nat Neurosci 2013;8:e73532
  63. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One 2013;8:e70427
  64. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
    Authors: Lotz Et al.
    PLoS One 2013;8:e56289
  65. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Authors: Briones-Orta Et al.
    Am J Stem Cells 2013;73:1800
  66. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front.Cell Neurosci. 2013;6:64
  67. The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Authors: Woodruff Et al.
    Cell Rep 2013;5:974
  68. Translating dosage compensation to trisomy 21.
    Authors: Jiang Et al.
    Nature 2013;500:296
  69. High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A 2013;3:2296
  70. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Authors: Kreitzer Et al.
    Nat Methods 2013;2:119
  71. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    Authors: Spender Et al.
    J Biol Chem 2013;288:5198
  72. Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
    Authors: Honda Et al.
    ACS Chem Neurosci 2013;288:26157
  73. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res 2013;247:694
  74. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Authors: Davila Et al.
    J Neurosci Methods 2013;216:104
  75. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas and
    Nat Neurosci 2013;16:1773
  76. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther 2013;14:638
  77. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    PLoS One 2013;11:1206
  78. Snail cooperates with KrasG12D to promote pancreatic fibrosis.
    Authors: Shields Et al.
    Mol Cancer Res 2013;11:1078
  79. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
    Authors: Shalom-Feuerstein Et al.
    Neuropsychopharmacology 2013;110:2152
  80. Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.
    Authors: Kusuma Et al.
    Antimicrob Agents Chemother 2013;110:12601
  81. A simple tool to improve pluripotent stem cell differentiation.
    Authors: Chetty Et al.
    Cell 2013;10:553
  82. High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
    Authors: Outten Et al.
    Curr Protoc Stem Cell Biol 2012;Chapter 1:Unit 1D.6
  83. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    Nat Biotechnol 2012;7:e49079
  84. TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
    Authors: Sohni Et al.
    PLoS One 2012;7:e47629
  85. Transposon-mediated BAC transgenesis in human ES cells.
    Authors: Rostovskaya Et al.
    Nucleic Acids Res 2012;40:e150
  86. A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells.
    Authors: Smith Et al.
    PLoS One 2012;3:518
  87. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A 2012;3:482
  88. Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
    Authors: Grönroos Et al.
    Mol Cell Biol 2012;32:2904
  89. Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
    Authors: Denham Et al.
    J Neurosci 2012;30:2400
  90. TGF-β blockade does not improve control of an established persistent viral infection.
    Authors: Boettler Et al.
    Viral Immunol 2012;25:232
  91. Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
    Authors: Mak Et al.
    Stem Cells Int 2012;2012:140427
  92. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    Authors: Shi Et al.
    Cancer Res 2012;15:477
  93. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.
    Authors: Boeuf Et al.
    BMC Cancer 2012;12:488
  94. Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
    Authors: Varela Et al.
    Sci Rep 2012;122:569
  95. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
    Authors: Valdez Et al.
    Nature 2012;11:676
  96. Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells.
    Authors: Hoda Et al.
    Br J Cancer 2012;107:1978
  97. Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
    Authors: Xie Et al.
    Proc Natl Acad Sci U S A 2011;Suppl 1
  98. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T-regulatory cells.
    Authors: Olkhanud Et al.
    Cancer Res 2011;71:3505
  99. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
    Authors: Bedel Et al.
    Cancer Res 2011;71:1615
  100. Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
    Authors: Wilson Et al.
    PLoS One 2011;6:e22842
  101. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
    Authors: Tan Et al.
    Nat Cell Biol 2011;6:e17124
  102. Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.
    Authors: Herman-Edelstein Et al.
    Diabetes 2011;60:1779
  103. Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
    Authors: Chen Et al.
    PLoS One 2011;4:9
  104. Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
    Authors: Duan Et al.
    J Clin Cell Immunol 2011;36:54
  105. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
    Authors: Seibler Et al.
    Shock 2011;31:5970
  106. Reversible differentiation of myofibroblasts by MyoD.
    Authors: Hecker Et al.
    PLoS One 2011;317:1914
  107. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
    Authors: Grocott Et al.
    Stem Cell Reports 2011;2:265
  108. Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
    Authors: Shields Et al.
    J Biol Chem 2011;286:10495
  109. β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
    Authors: Paek Et al.
    Dev Cell 2011;20:689
  110. A poised chromatin platform for TGF-β access to master regulators.
    Authors: Xi Et al.
    Biochem Biophys Res Commun 2011;147:1511
  111. Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
    Authors: Redondo Et al.
    PLoS One 2010;5:e9800
  112. Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes.
    Authors: Wang Et al.
    Nat Commun 2010;4:15
  113. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
    Authors: Ishida Et al.
    Dev Biol 2010;340:468
  114. Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.
    Authors: Fong Et al.
    J Biol Chem 2010;285:31427
  115. Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
    Authors: Moyano Et al.
    Mol Biol Cell 2010;21:3654
  116. PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.
    Authors: Ham Et al.
    J Cell Mol Med 2010;14:1747
  117. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
    Authors: Hannigan Et al.
    J Clin Invest 2010;120:2842
  118. Extracellular matrix-induced gene expression in human breast cancer cells.
    Authors: Garamszegi Et al.
    Mol Cancer Res 2009;7:319
  119. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
    Authors: Patsialou Et al.
    Cancer Res 2009;69:9498
  120. Pharmacological inhibition of transforming growth factor β signaling decreases infection and prevents heart damage in acute Chagas' disease.
    Authors: Waghabi Et al.
    Sci Rep 2009;53:4694
  121. Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
    Authors: Patani Et al.
    Oncotarget 2009;4:e7327
  122. Nodal signalling is involved in left-right asymmetry in snails.
    Authors: Grande and Patel
    J Cell Commun Signal 2009;457:1007
  123. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
    Authors: Cacheaux Et al.
    J Neurosci 2009;29:8927
  124. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics.
    Authors: Clarke Et al.
    Mol Cell Biol 2009;29:2443
  125. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
    Authors: Li Et al.
    Stem Cells 2009;27:2992
  126. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
    Authors: Chambers Et al.
    J Biotechnol 2009;27:275
  127. Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility.
    Authors: Giampieri Et al.
    J Biol Chem 2009;11:1287
  128. Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-α.
    Authors: Ding and Warburton
    Hypertens Res 2008;375:460
  129. Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression.
    Authors: Yang Et al.
    Oncogene 2008;27:5326
  130. A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization.
    Authors: Stoikos Et al.
    Hum Reprod 2008;23:1447
  131. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor.
    Authors: Gressner Et al.
    J Cell Mol Med 2008;12:2717
  132. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang Et al.
    Blood 2008;111:1933
  133. Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
    Authors: Horowitz Et al.
    Cell Signal 2007;19:761
  134. Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation.
    Authors: Castañares Et al.
    Genes Dev 2007;120:1256
  135. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
    Authors: Zhao Et al.
    Biochem Biophys Res Commun 2006;350:385
  136. Transforming growth factor-β signaling enhances transdifferentiation of macrophages into smooth muscle-like cells.
    Authors: Ninomiya Et al.
    Mol Cell Biol 2006;29:269
  137. Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
    Authors: Shi-Wen Et al.
    Exp Cell Res 2006;26:5518
  138. Identification of phosphatases for Smad in the BMP/DPP pathway.
    Authors: Chen Et al.
    Sci Rep 2006;20:648
  139. Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells.
    Authors: Anumanthan Et al.
    Br J Cancer 2005;93:1157
  140. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling.
    Authors: König Et al.
    J Cell Biol 2005;168:1077
  141. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
    Authors: Chen Et al.
    Am J Pathol 2005;167:1699
  142. Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma.
    Authors: Mimura Et al.
    Clin Cancer Res 2005;11:4898
Expand to show all 142 Citations

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