SB 431542

  ( 179 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1614
Chemical Name:4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Product Details
Citations (179)
Supplemental Products
Reviews
Biological Activity
Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.
Technical Data
  • M.Wt:
    384.39
  • Formula:
    C22H16N4O3
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    301836-41-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

179 Citations: Showing 1 - 10
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  1. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  2. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    Authors: Offermann Et al.
    Oncotarget  2017;8:7964
  3. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  4. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
    Authors: Christoforou Et al.
    Sci Rep  2017;7:40285
  5. Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
    Authors: Kunnen Et al.
    Cell Mol Life Sci  2017;74:2283
  6. Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
    Authors: Yang Et al.
    Cell Mol Gastroenterol Hepatol  2017;3:484
  7. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  8. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  9. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
    Authors: Saini Et al.
    Cell Stem Cell  2017;20:635
  10. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  11. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC Cancer  2017;17(1):202
  12. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  13. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells  2016;8:e65580
  14. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
    Authors: Spender Et al.
    Oncotarget  2016;7:81995
  15. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy  2016;7:174
  16. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  17. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc  2016;6:21518
  18. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2016;6:19727
  19. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol  2016;6:19533
  20. Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
    Authors: Topalovski Et al.
    J Biol Chem  2016;291:22244
  21. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  22. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  23. Activin A programs the differentiation of human TFH cells.
    Authors: Locci Et al.
    Nat Immunol  2016;17:976
  24. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  25. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
    Authors: Maturana Et al.
    J Neuroinflammation  2016;13:295
  26. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens  2016;12:e1005991
  27. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One  2016;11:e0165497
  28. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep  2015;89:5134
  29. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  30. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol  2015;6:8896
  31. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun  2015;6:7264
  32. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest  2015;6:5
  33. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther  2015;6:125
  34. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol  2015;63:420
  35. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer  2015;61:42626
  36. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol  2015;5:660
  37. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev  2015;5:323
  38. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo  2015;5:16872
  39. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol  2015;5:11252
  40. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest  2015;5:1010
  41. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One  2015;52:1850
  42. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest  2015;400:129
  43. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  44. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev  2015;3:e1486
  45. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med  2015;330:29
  46. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet  2015;26:205
  47. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun  2015;263:190
  48. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports  2015;24:5260
  49. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol  2015;24:2591
  50. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain  2015;21:276
  51. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  52. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol  2015;17:615
  53. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  54. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Authors: Wilson Et al.
    Sci Rep  2015;15:55
  55. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports  2015;142:3166
  56. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  57. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  58. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep  2015;125:3008
  59. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol  2015;125:2032
  60. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell  2015;11:e1004453
  61. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ  2015;10:e0125590
  62. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  63. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One  2015;10:e0116995
  64. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res  2015;10:413
  65. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One  2014;9:e91269
  66. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis  2014;70:12
  67. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One  2014;4:7323
  68. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med  2014;3:1169
  69. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.
    Authors: Aguila Et al.
    Stem Cells Transl Med  2014;3:1032
  70. miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Authors: Rosa Et al.
    Dev Biol  2014;391:81
  71. Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
    Authors: Magaña Et al.
    Dev Biol  2014;387:15
  72. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
    Authors: Curado Et al.
    Exp Neurol  2014;34:4389
  73. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
    Authors: Orlova Et al.
    Arterioscler Thromb Vasc Biol  2014;34:177
  74. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  75. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    Authors: O'Reilly Et al.
    J Biol Chem  2014;289:9952
  76. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
    Authors: Wu Et al.
    Fibrogenesis Tissue Repair  2014;289:20193
  77. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
    Authors: Fang Et al.
    J Pharm Sci Pharmacol  2014;1:175
  78. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
    Authors: Soares Et al.
    Cell Stem Cell  2014;173:53
  79. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  80. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    J Cell Sci  2014;111:18126
  81. Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
    Authors: Razak Et al.
    Nat Neurosci  2013;8:e73532
  82. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  83. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
    Authors: Lotz Et al.
    PLoS One  2013;8:e56289
  84. A novel model of dormancy for bone metastatic breast cancer cells.
    Authors: Marlow Et al.
    Cancer Res  2013;73:6886
  85. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Authors: Briones-Orta Et al.
    Am J Stem Cells  2013;73:1800
  86. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front.Cell Neurosci.  2013;6:64
  87. The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Authors: Woodruff Et al.
    Cell Rep  2013;5:974
  88. Translating dosage compensation to trisomy 21.
    Authors: Jiang Et al.
    Nature  2013;500:296
  89. High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;3:2296
  90. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Authors: Kreitzer Et al.
    Nat Methods  2013;2:119
  91. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    Authors: Spender Et al.
    J Biol Chem  2013;288:5198
  92. Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
    Authors: Honda Et al.
    ACS Chem Neurosci  2013;288:26157
  93. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res  2013;247:694
  94. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Authors: Davila Et al.
    J Neurosci Methods  2013;216:104
  95. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas and
    Nat Neurosci  2013;16:1773
  96. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther  2013;14:638
  97. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
    Authors: Rafiei and Komarova
    BMC Cancer  2013;13:605
  98. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    PLoS One  2013;11:1206
  99. Snail cooperates with KrasG12D to promote pancreatic fibrosis.
    Authors: Shields Et al.
    Mol Cancer Res  2013;11:1078
  100. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
    Authors: Shalom-Feuerstein Et al.
    Neuropsychopharmacology  2013;110:2152
  101. Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.
    Authors: Kusuma Et al.
    Antimicrob Agents Chemother  2013;110:12601
  102. A simple tool to improve pluripotent stem cell differentiation.
    Authors: Chetty Et al.
    Cell  2013;10:553
  103. High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
    Authors: Outten Et al.
    Curr Protoc Stem Cell Biol  2012;Chapter 1:Unit 1D.6
  104. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    Nat Biotechnol  2012;7:e49079
  105. TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
    Authors: Sohni Et al.
    PLoS One  2012;7:e47629
  106. Transposon-mediated BAC transgenesis in human ES cells.
    Authors: Rostovskaya Et al.
    Nucleic Acids Res  2012;40:e150
  107. A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells.
    Authors: Smith Et al.
    PLoS One  2012;3:518
  108. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A  2012;3:482
  109. Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
    Authors: Grönroos Et al.
    Mol Cell Biol  2012;32:2904
  110. Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
    Authors: Denham Et al.
    J Neurosci  2012;30:2400
  111. TGF-β blockade does not improve control of an established persistent viral infection.
    Authors: Boettler Et al.
    Viral Immunol  2012;25:232
  112. Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
    Authors: Mak Et al.
    Stem Cells Int  2012;2012:140427
  113. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    Authors: Shi Et al.
    Cancer Res  2012;15:477
  114. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
    Authors: Patsialou Et al.
    Breast Cancer Res  2012;14:R139
  115. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.
    Authors: Boeuf Et al.
    BMC Cancer  2012;12:488
  116. Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
    Authors: Varela Et al.
    Sci Rep  2012;122:569
  117. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
    Authors: Valdez Et al.
    Nature  2012;11:676
  118. Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
    Authors: Luo and Su
    PLoS Biol  2012;10:e1001402
  119. Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells.
    Authors: Hoda Et al.
    Br J Cancer  2012;107:1978
  120. Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
    Authors: Xie Et al.
    Proc Natl Acad Sci U S A  2011;Suppl 1
  121. Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling.
    Authors: Kurita and Wada
    Biol Lett  2011;7:759
  122. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T-regulatory cells.
    Authors: Olkhanud Et al.
    Cancer Res  2011;71:3505
  123. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
    Authors: Bedel Et al.
    Cancer Res  2011;71:1615
  124. Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
    Authors: Wilson Et al.
    PLoS One  2011;6:e22842
  125. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
    Authors: Tan Et al.
    Nat Cell Biol  2011;6:e17124
  126. Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.
    Authors: Herman-Edelstein Et al.
    Diabetes  2011;60:1779
  127. Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
    Authors: Chen Et al.
    PLoS One  2011;4:9
  128. Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
    Authors: Duan Et al.
    J Clin Cell Immunol  2011;36:54
  129. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
    Authors: Seibler Et al.
    Shock  2011;31:5970
  130. Reversible differentiation of myofibroblasts by MyoD.
    Authors: Hecker Et al.
    PLoS One  2011;317:1914
  131. Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression.
    Authors: Dangi-Garimella Et al.
    Oncogene  2011;30:1002
  132. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
    Authors: Grocott Et al.
    Stem Cell Reports  2011;2:265
  133. Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.
    Authors: Holley Et al.
    J Biol Chem  2011;286:6241
  134. Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
    Authors: Shields Et al.
    J Biol Chem  2011;286:10495
  135. β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
    Authors: Paek Et al.
    Dev Cell  2011;20:689
  136. A poised chromatin platform for TGF-β access to master regulators.
    Authors: Xi Et al.
    Biochem Biophys Res Commun  2011;147:1511
  137. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
    Authors: Ewan Et al.
    Cancer Res  2010;70:5963
  138. Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
    Authors: Redondo Et al.
    PLoS One  2010;5:e9800
  139. Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes.
    Authors: Wang Et al.
    Nat Commun  2010;4:15
  140. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
    Authors: Ishida Et al.
    Dev Biol  2010;340:468
  141. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent.
    Authors: James Et al.
    Nat Biotechnol  2010;28:161
  142. Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.
    Authors: Fong Et al.
    J Biol Chem  2010;285:31427
  143. Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
    Authors: Moyano Et al.
    Mol Biol Cell  2010;21:3654
  144. PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.
    Authors: Ham Et al.
    J Cell Mol Med  2010;14:1747
  145. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
    Authors: Hannigan Et al.
    J Clin Invest  2010;120:2842
  146. Extracellular matrix-induced gene expression in human breast cancer cells.
    Authors: Garamszegi Et al.
    Mol Cancer Res  2009;7:319
  147. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
    Authors: Patsialou Et al.
    Cancer Res  2009;69:9498
  148. Pharmacological inhibition of transforming growth factor β signaling decreases infection and prevents heart damage in acute Chagas' disease.
    Authors: Waghabi Et al.
    Sci Rep  2009;53:4694
  149. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.
    Authors: Xiao Et al.
    Invest Ophthalmol Vis Sci  2009;50:1698
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    Oncotarget  2009;4:e7327
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    J Neurosci  2009;29:8927
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  160. TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
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