Claudin-1 Antibody [Janelia Fluor® 669]

Name: Claudin-1 Antibody [Janelia Fluor® 669]
Brand: Novus Biologicals
SKU: NBP1-77036JF669
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-77036JF669

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Canine

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Janelia Fluor 669

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human Claudin-1. The immunogen is located within the last 50 amino acids of Claudin-1.

Reactivity Notes

Porcine reactivity per customer review. Mouse reactivity reported in (PMID: 33392105), Canine reactivity reported in (PMID: 32419902).

Specificity

Human Claudin-1 has one isoform (211aa, 23kD). Mouse Claudin-1 has one isoform (211aa, 23kD) and Rat Claudin-1 also has one isoform (211aa, 23kD). NBP1-77036 can detect human, mouse and rat.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Claudin-1 Antibody [Janelia Fluor® 669]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Claudin-1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Alternate Names

Claudin1, CLD1, CLDN1, SEMP1

Gene Symbol

CLDN1

Additional Claudin-1 Products

Product Documents for Claudin-1 Antibody [Janelia Fluor® 669]

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Certificate of Analysis

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Product Specific Notices for Claudin-1 Antibody [Janelia Fluor® 669]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.