CNQX

Tocris Bioscience | Catalog # 0190

Potent and selective non-NMDA iGluR antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective non-NMDA iGluR antagonist

Alternative Names

Cyanquixaline
View all AMPA Receptor Antagonists »

Product Description

CNQX is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

CNQX Disodium Salt (Cat. No. 1045) also available.

Product Specifications for CNQX

Molecular Weight

232.16

Formula

C9H4N4O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6-Cyano-7-nitroquinoxaline-2,3-dione

CAS Number

115066-14-3

PubChem ID

3721046

InChI Key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

SMILES

[O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.22 100

Preparing Stock Solutions for CNQX

The following data is based on the product molecular weight 232.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.54 mL 43.07 mL
5 mM 0.86 mL 4.31 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Calculators

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Product Documents for CNQX

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CNQX

For research use only

Customer Reviews for CNQX (1)

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  • CNQX impact on field potentials PPR
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Anterior singulate cortex
    Verified Customer | Posted 06/07/2019
    CNQX was used to study input of non-NMDA glutamate receptors into short-term plasticity in anterior cingulate cortex. Being applied in 5 microM concentration, CNQX reduced significantly both amplitudes of field potentials and their paired-pulse ratio.
    CNQX 0190

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