NBQX

Tocris Bioscience | Catalog # 0373

Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
Tocris Bioscience

Key Product Details

Description

Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
View all AMPA Receptor Antagonists »

Product Description

NBQX is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt, a more water-soluble form of NBQX, also available.

Licensing Information

Sold with the permission of Novo Nordisk A/S

Product Specifications for NBQX

Molecular Weight

336.28

Formula

C12H8N4O6S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

CAS Number

118876-58-7

PubChem ID

3272524

InChI Key

UQNAFPHGVPVTAL-UHFFFAOYSA-N

SMILES

NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C12)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.63 100

Preparing Stock Solutions for NBQX

The following data is based on the product molecular weight 336.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.87 mL 29.74 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.30 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 1748 publications citing the usage of this product.

Product Documents for NBQX

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NBQX

For research use only

Customer Reviews for NBQX (3)

4.7 out of 5
3 Customer Ratings
5 Stars
67%
4 Stars
33%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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  • Partial block of AMPARs
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cerebellar granule cell
    Verified Customer | Posted 12/15/2020
    NBQX was used to block evoked AMPA-receptor response in outside-out membrane patches excised from hippocampal granule cells. 0.1 µM concentration caused an immediate partial block (see illustration). Highly specific and potent ligand, but requires long sonication to prepare 10 mM DMSO stock. Illustration: I - control AMPAR response at -60 mV cell membrane potential; II - control AMPAR response at +40 mV cell membrane potential; III - NBQX at -60 mV cell membrane potential; IV - NBQX at +40 mV cell membrane potential.
    NBQX 0373
  • Inhibition of Synaptic Transmission in the VP
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/02/2020
    NBQX (5 mM)
    NBQX 0373
  • an AMPA receptor antagonist
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/31/2018
    It is AMPA receptor antagonist. we used it at 30uM to block AMPA receptor in rat brain slice.

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