CNQX disodium salt
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Biological ActivityCNQX disodium salt is a more water-soluble disodium salt of the AMPA and kainate antagonist CNQX (Cat. No. 0190), which is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM, 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
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Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
Honore et al.
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.
Watkins et al.
Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro.
King et al.
Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro.
Long et al.
Citations for CNQX disodium salt
The citations listed below are publications that use Tocris products. Selected citations for CNQX disodium salt include:
36 Citations: Showing 1 - 10
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
Authors: Pati Et al.
Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice.
Authors: He Et al.
Cell Rep 2020;33
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Authors: Evans Et al.
Cell Rep 2020;32
KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
Authors: Green and Thayer Et al.
Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.
Authors: Gutzmann Et al.
Front Cell Neurosci 2019;13:27
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
Authors: Kiritoshi and Neugebauer
ACS Chem Neurosci 2018;9:2252
A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration.
Authors: Grillo Et al.
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Authors: Leroy Et al.
Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus.
Authors: Jalalvand Et al.
J Neurosci 2018;38:7713
A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.
Authors: Yuan Et al.
J Biol Chem 2018;293:11625
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.
Authors: Riquelme Et al.
Front Cell Neurosci 2018;12:12
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
Authors: Maschi and Klyachko
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
Authors: Doshina Et al.
Sci Rep 2017;7:370
Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
Authors: Sternfeld Et al.
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Authors: Athilingam Et al.
Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems.
Authors: Edwards Et al.
ACS Biomater Sci Eng 2017;3:3525
A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.
Authors: Chaffiol Et al.
Mol Ther 2017;25:2546
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
Authors: Paul Et al.
Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Authors: Mauger Et al.
Differential Somatic Ca2+ Channel Profile in Midbrain DArgic Neurons
Authors: Philippart Et al.
The Journal of Neuroscience 2016;6:7234
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Authors: Cazares Et al.
J Neurosci 2016;36:11208
A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors.
Authors: Li Et al.
Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
Authors: Piet Et al.
Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
Authors: Baltz and Voigt
Front Cell Neurosci 2015;9:272
Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
Authors: Schitine Et al.
J Neurosci 2015;82:42
Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.
Authors: Einarsson Et al.
J Endocrinol 2015;40:480
Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Authors: Zhao Et al.
Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.
Authors: Villers Et al.
Learn Mem 2014;21:616
Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
Authors: Schubert Et al.
Acta Neuropathol 2014;128:835
Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
Authors: Guo Et al.
Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
Authors: Janssen Et al.
J Neurosci 2012;32:13889
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Authors: Carlson Et al.
Brain Behav 2012;2:391
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-MthD.-aspartate receptors.
Authors: Yuan Et al.
J Biol Chem 2009;284:12862
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