Catalog Number: 1045
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Biological Activity
More water soluble disodium salt of the AMPA/kainate antagonist CNQX (Cat. No. 0190). Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
    Honore et al.
    Science, 1988;241:701
  2. Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro.
    King et al.
    Br.J.Pharmacol., 1992;107:375
  3. Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro.
    Long et al.
    Br.J.Pharmacol., 1990;100:850
  4. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.
    Watkins et al.
    TiPS, 1990;11:25

The citations listed below are publications that use Tocris products. Selected citations for CNQX disodium salt include:

Showing Results 1 - 10 of 10

  1. Differential Somatic Ca2+�Channel Profile in Midbrain Dopaminergic Neurons
    Authors: Philippart Et al.
    The Journal of Neuroscience
  2. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
    Authors: Piet Et al.
  3. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci
  4. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    J Neurosci
  5. Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.
    Authors: Einarsson Et al.
    J Endocrinol
  6. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
  7. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol
  8. Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
    Authors: Guo Et al.
  9. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci
  10. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
    Authors: Yuan Et al.
    J Biol Chem
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