CNQX disodium salt

Tocris Bioscience | Catalog # 1045

Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)
Tocris Bioscience

Key Product Details

Description

Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)
View all AMPA Receptor Antagonists »

Product Description

CNQX disodium salt is a more water-soluble disodium salt of the AMPA and kainate antagonist CNQX (Cat. No. 0190), which is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM, 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

Product Specifications for CNQX disodium salt

Molecular Weight

276.12

Formula

C9H2N4O4Na2

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-Cyano-7-nitroquinoxaline-2,3-dione disodium

CAS Number

479347-85-8

PubChem ID

2821

InChI Key

YCXDDPGRZKUGDG-UHFFFAOYSA-L

SMILES

[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)C#N)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.76 10

Preparing Stock Solutions for CNQX disodium salt

The following data is based on the product molecular weight 276.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.22 mL 181.08 mL 362.16 mL
0.5 mM 7.24 mL 36.22 mL 72.43 mL
1 mM 3.62 mL 18.11 mL 36.22 mL
5 mM 0.72 mL 3.62 mL 7.24 mL

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Product Documents for CNQX disodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CNQX disodium salt

For research use only

Citations for CNQX disodium salt

Customer Reviews for CNQX disodium salt (3)

4.3 out of 5
3 Customer Ratings
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4 Stars
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  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    30uM CNQX
    CNQX disodium salt 1045
  • CNQX as an AMPA antagonist for whole cell recordings
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 04/30/2018
    The stock solution does not look uniform, so we stir it well before diluting to final concentration. In the picture you can see how the drug is coming out of solution (powder on the walls of the vial).
    AMPA antagonist used in whole cell recordings. We made a stock solution at 20mM in water and dilute to 10uM for experiments. EPSCs are wiped out, so this concentration appears effective despite concerns over uniformity.
    CNQX disodium salt 1045
  • CNQX
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/10/2018
    Stock solution is little sticky. Voltex well before making dilution.
    AMPA receptor antagonist used at 20uM in rat brain slice

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