CNQX disodium salt

  ( 13 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1045
Chemical Name:6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
More water soluble disodium salt of the AMPA/kainate antagonist CNQX (Cat. No. 0190). Also available as part of the Kainate Receptor Tocriset™.
Technical Data
  • M.Wt:
    276.12
  • Formula:
    C9H2N4O4Na2
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    479347-85-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CNQX disodium salt include:

13 Citations: Showing 1 - 10
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  1. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
    Authors: Doshina Et al.
    Sci Rep  2017;7:370
  2. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons
    Authors: Philippart Et al.
    The Journal of Neuroscience  2016;6:7234
  3. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
    Authors: Cazares Et al.
    J Neurosci  2016;36:11208
  4. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
    Authors: Piet Et al.
    Endocrinology.  2016;157:3621
  5. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci  2015;9:272
  6. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    J Neurosci  2015;82:42
  7. Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.
    Authors: Einarsson Et al.
    J Endocrinol  2015;40:480
  8. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    Neuropsychopharmacology  2015;35:308
  9. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol  2014;128:835
  10. Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
    Authors: Guo Et al.
    Biomaterials  2012;33:5723
  11. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci  2012;32:13889
  12. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  13. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
    Authors: Yuan Et al.
    J Biol Chem  2009;284:12862
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Average Rating: 4.5 (Based on 2 reviews)

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We have 2 reviews tested in 2 species: Mouse, Rat.

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  Very Good
  Mouse Anonymous 04/30/2018
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Summary

Species Mouse

Other Experimental Details

Other Experimental Details The stock solution does not look uniform, so we stir it well before diluting to final concentration. In the picture you can see how the drug is coming out of solution (powder on the walls of the vial).
  Excellent
  Rat Anonymous 01/10/2018
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Summary

Species Rat

Other Experimental Details

Other Experimental Details Stock solution is little sticky. Voltex well before making dilution.

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