CometAssay Single Cell Gel Electrophoresis Assay

Catalog # Availability Size / Price Qty
4250-050-K
Product Details
Citations (265)
FAQs
Reviews

CometAssay Single Cell Gel Electrophoresis Assay Summary

Includes twenty-five specially treated CometSlides (2 Well) and sufficient reagents for 50 test samples.

Key Benefits

• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions

Product Specifications

  • Applicable for the analysis of either single- or double-strand DNA breaks
  • Study cellular responses to DNA damage
  • Screen for inhibitors of DNA repair
  • Test chemicals for toxicity
  • Screen for environmental mutagens

What is the CometAssay?

The Comet assay, or single cell gel electrophoresis assay, provides a simple and effective method for evaluating DNA damage in cells. The principle of the assay is based upon the ability of denatured, cleaved DNA fragments to migrate out of the nucleoid under the influence of an electric field, whereas undamaged DNA migrates slower and remains within the confines of the nucleoid when a current is applied. Evaluation of the DNA “comet” tail shape and migration pattern allows for assessment of DNA damage. The general Comet assay protocol includes first immobilizing cells in a bed of low melting point agarose, gently lysing the cells, treating cells with neutral or alkali solutions to unwind and denature the DNA as well as hydrolyze sites of damage. DNA is then subjected to electrophoresis and stained with a fluorescent DNA intercalating dye.

Kit Contents

• CometAssay Lysis Solution
• CometAssay LMAgarose
• CometSlides (2 Well, 25 Slides)
• 200 mM EDTA, pH 10

Specifications

Shipping Conditions
The product is shipped ambient or with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store products immediately at the temperature recommended on the product labels.
Species
N/A

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Citations for CometAssay Single Cell Gel Electrophoresis Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

265 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
    Authors: Y Huang, X Yang, Y Lu, Y Zhao, R Meng, S Zhang, X Dong, S Xu, G Wu
    Cell Death Differ., 2020;0(0):.  2020
  2. 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
    Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
    Mar Drugs, 2020;18(8):.  2020
  3. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
    Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
    PLoS Genet., 2020;16(1):e1008558.  2020
  4. Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
    Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
    Nucleic Acids Res., 2020;0(0):.  2020
  5. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
    Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
    EMBO Mol Med, 2020;12(6):e10622.  2020
  6. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
    Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
    Cell Rep, 2020;31(2):107518.  2020
  7. Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
    Authors: E Kong, HD Kim, J Kim
    Cell Death Differ., 2020;0(0):.  2020
  8. Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
    Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
    Sci Rep, 2020;10(1):4943.  2020
  9. Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
    Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
    Molecules, 2020;25(5):.  2020
  10. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
    Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
    Theranostics, 2020;10(7):3351-3365.  2020
  11. Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
    Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
    Front Pharmacol, 2020;11(0):263.  2020
  12. Germline biallelic MCM8 variants are associated with early-onset Lynch-like syndrome
    Authors: M Golubicki, L Bonjoch, JG Acuña-Ocho, M Díaz-Gay, J Muñoz, M Cuatrecasa, T Ocaña, S Iseas, G Mendez, D Cisterna, SA Schubert, M Nielsen, T van Wezel, Y Goldberg, E Pikarsky, J Robbio, E Roca, A Castells, F Balaguer, M Antelo, S Castellví-
    JCI Insight, 2020;0(0):.  2020
  13. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
    Authors: S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.  2020
  14. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage
    Authors: FC Lam, YW Kong, Q Huang, TL Vu Han, AD Maffa, EM Kasper, MB Yaffe
    Nat Commun, 2020;11(1):4083.  2020
  15. An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
    Authors: L Gao, Y Zhang, L Zhao, W Niu, Y Tang, F Gao, P Cai, Q Yuan, X Wang, H Jiang, X Gao
    Sci Adv, 2020;6(29):eabb1421.  2020
  16. Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
    Authors: SE Noh, YS Juhnn
    Sci Rep, 2020;10(1):14455.  2020
  17. Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
    Authors: A Chakrabort, P Jenjaroenp, J Li, S El Hilali, A McCulley, B Haarer, EA Hoffman, A Belak, A Thorland, H Hehnly, C Schildkrau, CL Chen, VA Kuznetsov, W Feng
    Cell Rep, 2020;32(12):108179.  2020
  18. BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
    Authors: DS Edwards, R Maganti, JP Tanksley, J Luo, JJH Park, E Balkanska-, J Ling, SR Floyd
    Cell Rep, 2020;32(12):108166.  2020
  19. MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
    Authors: A Rodríguez, K Zhang, A Färkkilä, J Filiatraul, C Yang, M Velázquez, E Furutani, DC Goldman, B García de, G Garza-Mayé, K McQueen, LA Sambel, B Molina, L Torres, M González, E Vadillo, R Pelayo, WH Fleming, M Grompe, A Shimamura, S Hautaniemi, J Greenberge, S Frías, K Parmar, AD D'Andrea
    Cell Stem Cell, 2020;0(0):.  2020
  20. Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
    Authors: S Duan, L Hu, B Dong, HL Jin, HB Wang
    Cell Rep, 2020;32(6):108019.  2020
  21. PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
    Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
    Cell Rep, 2019;26(5):1333-1343.e7.  2019
  22. Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
    Authors: M Cucè, ME Gallo Cant, MA Siciliano, C Riillo, D Caracciolo, F Scionti, N Staropoli, V Zuccalà, L Maltese, A Di Vito, K Grillone, V Barbieri, M Arbitrio, MT Di Martino, M Rossi, N Amodio, P Tagliaferr, P Tassone, C Botta
    J Hematol Oncol, 2019;12(1):32.  2019
  23. MiR-34s negatively regulate homologous recombination through targeting RAD51
    Authors: S Chen, R Liu, Q Wang, Z Qi, Y Hu, P Zhou, Z Wang
    Arch. Biochem. Biophys., 2019;666(0):73-82.  2019
  24. The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
    Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
    Int J Mol Sci, 2019;20(8):.  2019
  25. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
    Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
    Cell Stem Cell, 2019;0(0):.  2019
  26. Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
    Authors: X Wang, X Chen, L Sun, W Qian
    PLoS Genet., 2019;15(4):e1008094.  2019
  27. PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells
    Authors: B Liu, L Lin, S Riazuddin, A Zubair, L Wang, LJ Di, R Li, TT Dong, CX Deng, WM Tong
    Int. J. Biochem. Cell Biol., 2019;109(0):40-58.  2019
  28. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
    Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
    Acta Neuropathol Commun, 2019;7(1):77.  2019
  29. OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
    Authors: Z Wu, M Qiu, Y Guo, J Zhao, Z Liu, H Wang, M Meng, Z Yuan, Z Mi
    Cancer Cell Int., 2019;19(0):99.  2019
  30. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis
    Authors: HJ Wen, S Gao, Y Wang, M Ray, MA Magnuson, CVE Wright, MP Di Maglian, TL Frankel, HC Crawford
    Cell Mol Gastroenterol Hepatol, 2019;0(0):.  2019
  31. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
    Authors: N Martinez-V, M Marigil, M García-Mou, M Gonzalez-H, JJ Aristu, LI Ramos-Garc, S Tejada, R Díez-Valle, A Patiño-Gar, OJ Becher, C Gomez-Manz, J Fueyo, MM Alonso
    Acta Neuropathol Commun, 2019;7(1):64.  2019
  32. A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells
    Authors: J Jiang, N Mao, H Hu, J Tang, D Han, S Liu, Q Wu, Y Liu, C Peng, J Lai, C Yang
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.  2019
  33. ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy
    Authors: MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, G Falkous, D Williams, P Cox, A Meynert, ES Raymond, H Morrison, S Brown, E Allan, I Aligianis, AP Jackson, BH Ramsahoye, A von Kriegs, RW Taylor, AJ Finch, DR FitzPatric
    PLoS Genet., 2019;15(3):e1007605.  2019
  34. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
    Authors: A Chaiprason, Z Janjetovic, TK Kim, SG Jarrett, JA D'Orazio, MF Holick, EKY Tang, RC Tuckey, U Panich, W Li, AT Slominski
    Redox Biol, 2019;24(0):101206.  2019
  35. Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
    Authors: A Wilson, V Menon, Z Khan, A Alam, L Litovchick, V Yakovlev
    Redox Biol, 2019;24(0):101169.  2019
  36. Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
    Authors: E Lee, H Jeon, M Lee, J Ryu, C Kang, S Kim, J Jung, Y Kwon
    Sci Rep, 2019;9(1):2494.  2019
  37. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
    Authors: D Zhang, X Hu, J Li, J Liu, L Baks-Te Bu, M Wiersma, NU Malik, DMS van Marion, M Tolouee, F Hoogstra-B, EAH Lanters, AM van Roon, AAF de Vries, DA Pijnappels, NMS de Groot, RH Henning, BJJM Brundel
    Nat Commun, 2019;10(1):1307.  2019
  38. Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
    Authors: T Lin, TC Lin, DJ McGrail, PK Bhupal, YH Ku, W Zhang, L Meng, SY Lin, G Peng, RYL Tsai
    Oncogene, 2019;0(0):.  2019
  39. Promotion of homology-directed DNA repair by polyamines
    Authors: CY Lee, GC Su, WY Huang, MY Ko, HY Yeh, GD Chang, SJ Lin, P Chi
    Nat Commun, 2019;10(1):65.  2019
  40. Epithelial?mesenchymal transition induced by bone morphogenetic protein 9 hinders cisplatin efficacy in ovarian cancer cells
    Authors: Y Wang, B Yang, J Zhao, X Yu, X Liu, L Zhang, Y Zhang, X Li, Z Zhai
    Mol Med Rep, 2019;0(0):.  2019
  41. PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
    Authors: C Lv, S Fu, Q Dong, Z Yu, G Zhang, C Kong, C Fu, Y Zeng
    J. Exp. Clin. Cancer Res., 2019;38(1):24.  2019
  42. Molecular damage and responses of oral keratinocyte to hydrogen peroxide
    Authors: KY Lin, CH Chung, JS Ciou, PF Su, PW Wang, DB Shieh, TC Wang
    BMC Oral Health, 2019;19(1):10.  2019
  43. Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
    Authors: FJ Chou, Y Chen, D Chen, Y Niu, G Li, P Keng, S Yeh, C Chang
    EBioMedicine, 2019;0(0):.  2019
  44. Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
    Authors: P Nagarajan, PA Agudelo Ga, CC Iyer, LV Popova, WD Arnold, MR Parthun
    Aging Cell, 2019;0(0):e12992.  2019
  45. Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes
    Authors: S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang
    Cell Rep, 2019;26(8):2194-2211.e6.  2019
  46. Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica
    Authors: X Shao, B Zhao, B Wang, B Zhao, Y Zhu, Z Yuan, J Zhang
    Ecotoxicol. Environ. Saf., 2019;175(0):39-47.  2019
  47. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
    Authors: J Wang, B Chan, M Tong, Y Paung, U Jo, D Martin, M Seeliger, J Haley, H Kim
    PLoS Genet., 2019;15(2):e1007983.  2019
  48. MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1
    Authors: Y Dai, X Lin, W Xu, X Lin, Q Huang, L Shi, Y Pan, Y Zhang, Y Zhu, C Li, L Liu, S Zhang
    Cell Death Dis, 2019;10(2):144.  2019
  49. Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
    Authors: Z Qi, Y Song, Q Ding, X Liao, R Li, G Liu, S Tsang, Z Cai
    Ecotoxicol. Environ. Saf., 2019;168(0):378-387.  2019
  50. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
    Authors: G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka, AC Barros, M Woods, B Fu, F Yang, E Chen, M Ostermaier, T Stankovic, H Ponstingl, M Herzog, K Yusa, FM Martinez, ST Durant, Y Galanty, P Beli, DJ Adams, A Bradley, E Metzakopia, JV Forment, SP Jackson
    Nat Commun, 2019;10(1):87.  2019
  51. miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC? and ZEB1 inhibition
    Authors: R El Bezawy, S Tinelli, M Tortoreto, V Doldi, V Zuco, M Folini, C Stucchi, T Rancati, R Valdagni, P Gandellini, N Zaffaroni
    J. Exp. Clin. Cancer Res., 2019;38(1):51.  2019
  52. A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
    Authors: M Wu, Y Wang, D Yang, Y Gong, F Rao, R Liu, Y Danna, J Li, J Fan, J Chen, W Zhang, Q Zhan
    EBioMedicine, 2019;0(0):.  2019
  53. miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis
    Authors: J Tao, M Fan, D Zhou, Y Hong, J Zhang, H Liu, S Sharma, G Wang, Q Dong
    Oxid Med Cell Longev, 2019;2019(0):2352079.  2019
  54. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019;10(4):274.  2019
  55. Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
    Authors: S Giovannini, MC Weller, S Repmann, H Moch, J Jiricny
    Nucleic Acids Res., 2019;0(0):.  2019
  56. Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma
    Authors: AM Robinson, R Rathore, NJ Redlich, DR Adkins, T VanArsdale, BA Van Tine, LS Michel
    Cell Death Dis, 2019;10(11):867.  2019
  57. Male mice, caged in the International Space Station for 35 days, sire healthy offspring
    Authors: T Matsumura, T Noda, M Muratani, R Okada, M Yamane, A Isotani, T Kudo, S Takahashi, M Ikawa
    Sci Rep, 2019;9(1):13733.  2019
  58. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
    Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
    Sci Rep, 2019;9(1):19035.  2019
  59. IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
    Authors: J Panneersel, A Srivastava, M Mehta, A Chen, YD Zhao, A Munshi, R Ramesh
    Cancers (Basel), 2019;11(12):.  2019
  60. Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
    Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
    Nat Commun, 2019;10(1):5349.  2019
  61. Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
    Authors: G Urrutia, A Salmonson, JA Toro-Zapat, TM de Assunca, A Mathison, N Dusetti, J Iovanna, R Urrutia, G Lomberk
    Mol. Cancer Res., 2019;0(0):.  2019
  62. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
    Authors: D Andrade, M Mehta, J Griffith, S Oh, J Corbin, A Babu, S De, A Chen, YD Zhao, S Husain, S Roy, L Xu, J Aube, R Janknecht, M Gorospe, T Herman, R Ramesh, A Munshi
    Cancers (Basel), 2019;11(12):.  2019
  63. Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
    Authors: S Zhang, J Zhang, W Cheng, H Chen, A Wang, Y Liu, H Hou, Q Hu
    Chemosphere, 2019;244(0):125482.  2019
  64. Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
    Authors: Y Yu, W Jia, Y Lyu, D Su, M Bai, J Shen, J Qiao, T Han, W Liu, J Chen, W Chen, D Ye, X Guo, S Zhu, J Xi, R Zhu, X Wan, S Gao, J Zhu, J Kang
    Cell Discov, 2019;5(0):47.  2019
  65. Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
    Authors: JF Putri, P Bhargava, JK Dhanjal, T Yaguchi, D Sundar, SC Kaul, R Wadhwa
    J. Exp. Clin. Cancer Res., 2019;38(1):499.  2019
  66. Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response
    Authors: J Dziegielew, MA Bo?kowska, EA Poniecka, J Heo, K Du, RB Crittenden, TP Bender, DL Brautigan, JM Larner
    DNA Repair (Amst.), 2019;85(0):102737.  2019
  67. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts
    Authors: EY Chang, S Tsai, MJ Aristizaba, JP Wells, Y Coulombe, FF Busatto, YA Chan, A Kumar, Y Dan Zhu, AY Wang, LA Fournier, P Hieter, MS Kobor, JY Masson, PC Stirling
    Nat Commun, 2019;10(1):4265.  2019
  68. APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
    Authors: CD Stefanski, K Keffler, S McClintock, L Milac, JR Prosperi
    Neoplasia, 2019;21(12):1143-1150.  2019
  69. Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
    Authors: DS Metselaar, MH Meel, B Benedict, P Waranecki, J Koster, GJL Kaspers, E Hulleman
    EBioMedicine, 2019;0(0):.  2019
  70. ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
    Authors: SH Park, N Kang, E Song, M Wie, EA Lee, S Hwang, D Lee, JS Ra, IB Park, J Park, S Kang, JH Park, S Hohng, KY Lee, K Myung
    Nat Commun, 2019;10(1):5718.  2019
  71. Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
    Authors: M Hong, J Li, S Li, M M Almutair
    Cells, 2019;8(11):.  2019
  72. Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
    Authors: C Mani, S Jonnalagad, J Lingareddy, S Awasthi, WH Gmeiner, K Palle
    Breast Cancer Res., 2019;21(1):104.  2019
  73. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
    Authors: JP Cebrià-Cos, L Pascual-Re, A Gonzalez-P, G Serra-Bard, J Querol, M Cosín, G Verde, RA Cigliano, W Sanseverin, S Segura-Bay, A Iturbide, D Andreu, P Nuciforo, C Bernado-Mo, V Rodilla, J Arribas, J Yelamos, AG de Herrero, TH Stracker, S Peiró
    Oncogene, 2019;0(0):.  2019
  74. BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
    Authors: TY Lin, HH Chan, SH Chen, S Sarvagalla, PS Chen, MS Coumar, SM Cheng, YC Chang, CH Lin, E Leung, CHA Cheung
    Autophagy, 2019;0(0):1-18.  2019
  75. Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
    Authors: Y Zhou, Y Xu, L Lu, J Ni, J Nie, J Cao, Y Jiao, Q Zhang
    Theranostics, 2019;9(22):6665-6675.  2019
  76. Precision Chemo-Radiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
    Authors: DV Hingorani, MK Doan, MF Camargo, J Aguilera, SM Song, D Pizzo, DJ Scanderbeg, EEW Cohen, AM Lowy, SR Adams, SJ Advani
    Mol. Cancer Ther., 2019;0(0):.  2019
  77. Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia
    Authors: SEF Kost, A Saleh, EM Mejia, M Mostafizar, EDJ Bouchard, V Banerji, AJ Marshall, SB Gibson, JB Johnston, S Katyal
    Cancers (Basel), 2019;11(10):.  2019
  78. The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas
    Authors: F Valenti, A Sacconi, F Ganci, G Grasso, S Strano, G Blandino, S Di Agostin
    Cancers (Basel), 2019;11(9):.  2019
  79. TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
    Authors: J Chen, Z Wang, X Guo, F Li, Q Wei, X Chen, D Gong, Y Xu, W Chen, Y Liu, J Kang, Y Shi
    Nat Commun, 2019;10(1):4273.  2019
  80. Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
    Authors: A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, P Calsou, Y Pommier, G Favre, G Capranico, N Gromak, O Sordet
    Cell Rep, 2019;28(12):3167-3181.e6.  2019
  81. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
    Authors: AL Perl, CM O'Connor, P Fa, F Mayca Pozo, J Zhang, Y Zhang, G Narla
    J. Biol. Chem., 2019;0(0):.  2019
  82. Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
    Authors: S Lin, L Yu, X Song, J Bi, L Jiang, Y Wang, M He, Q Xiao, M Sun, OI Olopade, L Zhao, M Wei
    Cell Death Dis, 2019;10(9):666.  2019
  83. Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells
    Authors: A Kopacz, D Klóska, B Proniewski, D Cysewski, N Personnic, A Piechota-P, P Kaczara, A Zakrzewska, HJ Forman, J Dulak, A Józkowicz, A Grochot-Pr
    Redox Biol, 2019;28(0):101304.  2019
  84. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
    Authors: X Xiao, J Liang, C Huang, K Li, F Xing, W Zhu, Z Lin, W Xu, G Wu, J Zhang, X Lin, Y Tan, J Cai, J Hu, X Chen, Y Huang, Z Qin, P Qiu, X Su, L Chen, Y Lin, H Zhang, G Yan
    Nat Commun, 2018;9(1):4342.  2018
  85. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
    Authors: D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha
    Nat Commun, 2018;9(1):5351.  2018
  86. Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism.
    Authors: Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J
    Cancer Res, 2015;75(13):2663-73.  2015
  87. Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.
    Authors: Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, Qin Z
    Blood, 2015;126(26):2821-31.  2015
  88. Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
    Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
    J Pharmacol Exp Ther, 2014;348(3):360-71.  2014
  89. CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
    Authors: Shibata E, Dar A, Dutta A
    J Biol Chem, 2014;289(33):23056-64.  2014
  90. Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
    Authors: Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan A, Boulton S, Ganesan S
    J Biol Chem, 2013;288(45):32357-69.  2013
  91. Low and high linear energy transfer radiation sensitization of HCC cells by metformin.
    Authors: Kim E, Kim M, Cho C, Jung W, Jeong Y, Jeong J
    J Radiat Res, 2013;55(3):432-42.  2013
  92. DNA damage in normally and prematurely aged mice.
    Authors: Maslov A, Ganapathi S, Westerhof M, Quispe-Tintaya W, White R, Van Houten B, Reiling E, Dolle M, van Steeg H, Hasty P, Hoeijmakers J, Vijg J
    Aging Cell, 2013;12(3):467-77.  2013
  93. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
    Authors: Lee AY, Chiba T, Truong LN
    J. Biol. Chem., 2012;287(4):2531-43.  2012
  94. BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress.
    Authors: Liu Y, Vaithiyalingam S, Shi Q
    Mol. Cell. Biol., 2011;31(21):4298-309.  2011
  95. Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
    Authors: Boichuk S, Hu L, Hein J
    J. Virol., 2010;84(16):8007-20.  2010
  96. The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
    Authors: Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S
    Blood, 2007;111(4):1951-61.  2007
  97. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
    Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
    Gut, 2006;56(2):243-52.  2006
  98. Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration.
    Authors: Swa H, Blackstock W, Lim L, Gunaratne J
    Mol Cell Proteomics, 0;11(8):381-93.  0
  99. RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
    Authors: Kujjo L, Ronningen R, Ross P, Pereira R, Rodriguez R, Beyhan Z, Goissis M, Baumann T, Kagawa W, Camsari C, Smith G, Kurumizaka H, Yokoyama S, Cibelli J, Perez G
    Biol Reprod, 0;86(3):76.  0
  100. Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.
    Authors: Yuan S, Hou M, Hsieh Y, Huang C, Lee Y, Chen Y, Lo S
    J Natl Cancer Inst, 0;104(19):1485-502.  0
  101. Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer.
    Authors: Flaherty R, Owen M, Fagan-Murphy A, Intabli H, Healy D, Patel A, Allen M, Patel B, Flint M
    Breast Cancer Res, 0;19(1):35.  0
  102. RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
    Authors: Su C, Zhao H, Zhao Y, Ji H, Wang Y, Zhi L, Li X
    Sci Rep, 0;7(0):43897.  0
  103. Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
    Authors: Cerniglia G, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A
    Mol Pharmacol, 0;82(6):1230-40.  0
  104. Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.
    Authors: Jacobs K, Misri S, Meyer B, Raj S, Zobel C, Sleckman B, Hallahan D, Sharma G
    Mol Biol Cell, 0;27(8):1332-45.  0
  105. Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.
    Authors: Sperlazza J, Rahmani M, Beckta J, Aust M, Hawkins E, Wang S, Zu Zhu S, Podder S, Dumur C, Archer K, Grant S, Ginder G
    Blood, 0;126(12):1462-72.  0
  106. Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
    Authors: Kondratova A, Watanabe T, Marotta M, Cannon M, Segall A, Serre D, Tanaka H
    Nucleic Acids Res, 0;43(5):2678-90.  0
  107. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas.
    Authors: Cho H, Wang W, Jhaveri N, Lee D, Sharma N, Dubeau L, Schonthal A, Hofman F, Chen T
    Mol Cancer Ther, 0;13(8):2004-17.  0
  108. Effects of corexit oil dispersants and the WAF of dispersed oil on DNA damage and repair in cultured human bronchial airway cells, BEAS-2B.
    Authors: Major D, Derbes R, Wang H, Roy-Engel A
    Gene Rep, 0;3(0):22-30.  0
  109. Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates.
    Authors: Zhang R, Yang J, Sima M, Zhou Y, Kopecek J
    Proc Natl Acad Sci U S A, 0;111(33):12181-6.  0
  110. PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway.
    Authors: Chandra A, Lin T, Zhu J, Tong W, Huo Y, Jia H, Zhang Y, Liu X, Cengel K, Xia B, Qin L
    J Biol Chem, 0;290(1):157-67.  0
  111. A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
    Authors: Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari P, Stewart A, Giglia-Mari G, Snijders A, Vermeulen W, Svejstrup J
    Nucleic Acids Res, 0;44(11):5246-55.  0
  112. CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
    Authors: Subramanian C, Hada M, Opipari A, Castle V, Kwok R
    Mol Cancer Res, 0;11(2):173-81.  0
  113. miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair.
    Authors: Czochor J, Sulkowski P, Glazer P
    Mol Cancer Res, 0;14(4):363-73.  0
  114. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.
    Authors: Bolderson E, Petermann E, Croft L, Suraweera A, Pandita R, Pandita T, Helleday T, Khanna K, Richard D
    Nucleic Acids Res, 0;42(10):6326-36.  0
  115. Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).
    Authors: Wei L, Nakajima S, Hsieh C, Kanno S, Masutani M, Levine A, Yasui A, Lan L
    J Cell Sci, 0;126(0):4414-23.  0
  116. Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair.
    Authors: Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, Ying Z, Wu J, Li M, Li J
    J Mol Cell Biol, 0;4(2):108-17.  0
  117. USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.
    Authors: Knobel P, Belotserkovskaya R, Galanty Y, Schmidt C, Jackson S, Stracker T
    Mol Cell Biol, 0;34(11):2062-74.  0
  118. CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.
    Authors: Pal R, Ramdzan Z, Kaur S, Duquette P, Marcotte R, Leduy L, Davoudi S, Lamarche-Vane N, Iulianella A, Nepveu A
    J Biol Chem, 0;290(37):22520-31.  0
  119. The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
    Authors: Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P
    Acta Biochim Biophys Sin (Shanghai), 0;47(10):834-41.  0
  120. Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma.
    Authors: Liu J, Sun X, Zhu H, Qin Q, Yang X, Sun X
    J Biochem, 0;160(4):195-204.  0
  121. A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
    Authors: Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron D, Ellul J, Goodall G, Wong L, Dhillon A, Hamdane N, Rothblum L, Pearson R, Haviv I, Moss T, Hannan R
    Genome Res, 0;25(2):201-12.  0
  122. Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
    Authors: Santamaria Nunez G, Robles C, Giraudon C, Martinez-Leal J, Compe E, Coin F, Aviles P, Galmarini C, Egly J
    Mol Cancer Ther, 0;15(10):2399-2412.  0
  123. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.
    Authors: Song H, Hedayati M, Hobbs R, Shao C, Bruchertseifer F, Morgenstern A, Deweese T, Sgouros G
    Mol Cancer Ther, 0;12(10):2043-54.  0
  124. RhoB promotes gammaH2AX dephosphorylation and DNA double-strand break repair.
    Authors: Mamouni K, Cristini A, Guirouilh-Barbat J, Monferran S, Lemarie A, Faye J, Lopez B, Favre G, Sordet O
    Mol Cell Biol, 0;34(16):3144-55.  0
  125. The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.
    Authors: Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung T, Laslett A, Willam C, Qin B, Maxwell P, Esteban M
    J Biol Chem, 0;289(6):3339-51.  0
  126. Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy.
    Authors: Aji Alex M, Nehate C, Veeranarayanan S, Kumar D, Kulshreshtha R, Koul V
    Biomaterials, 0;133(0):94-106.  0
  127. The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress.
    Authors: Lee M, Wang L, Chang Z
    Nucleic Acids Res, 0;42(8):4972-84.  0
  128. Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci.
    Authors: Kines K, Sokolowski M, deHaro D, Christian C, Belancio V
    Nucleic Acids Res, 0;42(16):10488-502.  0
  129. Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia.
    Authors: Wu M, Wang X, McGregor N, Pienta K, Zhang J
    Mol Pharmacol, 0;85(6):866-76.  0
  130. 53BP1 promotes microhomology-mediated end-joining in G1-phase cells.
    Authors: Xiong X, Du Z, Wang Y, Feng Z, Fan P, Yan C, Willers H, Zhang J
    Nucleic Acids Res, 0;43(3):1659-70.  0
  131. YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
    Authors: Stachelek G, Peterson-Roth E, Liu Y, Fernandez R, Pike L, Qian J, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer P
    Mol Cancer Res, 0;13(10):1389-97.  0
  132. DNA damage in human skin keratinocytes caused by multiwalled carbon nanotubes with carboxylate functionalization.
    Authors: McShan D, Yu H
    Toxicol Ind Health, 0;30(6):489-98.  0
  133. Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice.
    Authors: Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J
    Cell Rep, 0;18(12):2880-2892.  0
  134. Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage.
    Authors: Huang V, Lee C, Lee Y, Lam K, Ko J, Yeung W, Ho P, Chiu P
    Mol Hum Reprod, 0;21(6):516-26.  0
  135. Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.
    Authors: Xu H, Zhou X, Wen X, Lauer F, Liu K, Hudson L, Aleksunes L, Burchiel S
    Toxicol Sci, 0;149(1):31-41.  0
  136. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
    Authors: Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt C, Zhao Y, Lum L, Zaman A, Yeaman C, White M, Pandita T
    Mol Cell Biol, 0;35(21):3633-45.  0
  137. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
    Authors: Nathanson D, Armijo A, Tom M, Li Z, Dimitrova E, Austin W, Nomme J, Campbell D, Ta L, Le T, Lee J, Darvish R, Gordin A, Wei L, Liao H, Wilks M, Martin C, Sadeghi S, Murphy J, Boulos N, Phelps M, Faull K, Herschman H, Jung M, Czernin J, Lavie A, Radu C
    J Exp Med, 0;211(3):473-86.  0
  138. BCL2 suppresses PARP1 function and nonapoptotic cell death.
    Authors: Dutta C, Day T, Kopp N, van Bodegom D, Davids M, Ryan J, Bird L, Kommajosyula N, Weigert O, Yoda A, Fung H, Brown J, Shapiro G, Letai A, Weinstock D
    Cancer Res, 0;72(16):4193-203.  0
  139. Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.
    Authors: Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, McCluskey A, St John J, Hansbro P, McLaughlin E
    Hum Reprod, 0;29(12):2719-35.  0
  140. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.
    Authors: Moureau S, Luessing J, Harte E, Voisin M, Lowndes N
    Open Biol, 0;6(9):.  0
  141. Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer.
    Authors: Jabbour-Leung N, Chen X, Bui T, Jiang Y, Yang D, Vijayaraghavan S, McArthur M, Hunt K, Keyomarsi K
    Mol Cancer Ther, 0;15(4):593-607.  0
  142. Differences in quantification of DNA double-strand breaks assessed by 53BP1/gammaH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.
    Authors: Kurashige T, Shimamura M, Nagayama Y
    J Radiat Res, 0;57(3):312-7.  0
  143. Radioprotective properties of tocopherol succinate against ionizing radiation in mice.
    Authors: Singh V, Singh P, Wise S, Posarac A, Fatanmi O
    J Radiat Res, 0;54(2):210-20.  0
  144. Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
    Authors: Lee H, Yoon C, Schmidt B, Park D, Zhang A, Erkizan H, Toretsky J, Kirsch D, Yoon S
    Mol Cancer Ther, 0;12(11):2591-600.  0
  145. (212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.
    Authors: Yong K, Milenic D, Baidoo K, Brechbiel M
    Mol Cancer Ther, 0;11(3):639-48.  0
  146. Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the beta-adrenoceptor/cAMP/protein kinase A axis during oxidative stress.
    Authors: Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C
    Mol Pharmacol, 0;86(4):450-62.  0
  147. Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
    Authors: Meng F, Evans J, Bhupathi D, Banica M, Lan L, Lorente G, Duan J, Cai X, Mowday A, Guise C, Maroz A, Anderson R, Patterson A, Stachelek G, Glazer P, Matteucci M, Hart C
    Mol Cancer Ther, 0;11(3):740-51.  0
  148. Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells.
    Authors: Haro K, Scott A, Scheinberg D
    Blood, 0;120(10):2087-97.  0
  149. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
    Authors: Pfaffle H, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes C, Sequist L, Zou L, Willers H
    Cancer Res, 0;73(20):6254-63.  0
  150. Human CDK18 promotes replication stress signaling and genome stability.
    Authors: Barone G, Staples C, Ganesh A, Patterson K, Bryne D, Myers K, Patil A, Eyers C, Maslen S, Skehel J, Eyers P, Collis S
    Nucleic Acids Res, 0;44(18):8772-8785.  0
  151. DNA double-strand break repair: a theoretical framework and its application.
    Authors: Murray P, Cornelissen B, Vallis K, Chapman S
    J R Soc Interface, 0;13(114):20150679.  0
  152. A novel role of Kruppel-like factor 8 in DNA repair in breast cancer cells.
    Authors: Lu H, Hu L, Li T, Lahiri S, Shen C, Wason M, Mukherjee D, Xie H, Yu L, Zhao J
    J Biol Chem, 0;287(52):43720-9.  0
  153. Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.
    Authors: Kaur S, Coulombe Y, Ramdzan Z, Leduy L, Masson J, Nepveu A
    J Biol Chem, 0;291(43):22769-22780.  0
  154. Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.
    Authors: Morgan C, Diaz J, Zeitlin S, Gray D, Wells J
    Proc Natl Acad Sci U S A, 0;112(27):8344-9.  0
  155. Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols.
    Authors: Behar R, Luo W, Lin S, Wang Y, Valle J, Pankow J, Talbot P
    Tob Control, 0;25(0):ii94-ii102.  0
  156. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.
    Authors: Sayers C, Papandreou I, Guttmann D, Maas N, Diehl J, Witze E, Koong A, Koumenis C
    Mol Pharmacol, 0;83(3):594-604.  0
  157. Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.
    Authors: Garcia J, Chen J, Guillory B, Donehower L, Smith R, Lamb D
    Biol Reprod, 0;93(1):24.  0
  158. Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.
    Authors: Artesi M, Kroonen J, Bredel M, Nguyen-Khac M, Deprez M, Schoysman L, Poulet C, Chakravarti A, Kim H, Scholtens D, Seute T, Rogister B, Bours V, Robe P
    Neuro Oncol, 0;17(3):392-406.  0
  159. Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
    Authors: Qin Q, Xie H, Wise S, Browning C, Thompson K, Holmes A, Wise J
    Toxicol Sci, 0;142(1):117-25.  0
  160. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
    Authors: Trinh B, Ko S, Barengo N, Lin S, Naora H
    Cancer Res, 0;73(2):1000-10.  0
  161. BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
    Authors: Ge C, Che L, Ren J, Pandita R, Lu J, Li K, Pandita T, Du C
    Proc Natl Acad Sci U S A, 0;112(11):E1210-9.  0
  162. Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.
    Authors: Verhalen B, Justice J, Imperiale M, Jiang M
    J Virol, 0;89(9):5032-9.  0
  163. HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs.
    Authors: Vernin C, Thenoz M, Pinatel C, Gessain A, Gout O, Delfau-Larue M, Nazaret N, Legras-Lachuer C, Wattel E, Mortreux F
    Cancer Res, 0;74(21):6082-93.  0
  164. Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
    Authors: Alli E, Solow-Cordero D, Casey S, Ford J
    Cancer Res, 0;74(21):6205-15.  0
  165. Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications.
    Authors: Wang L, Meng D, Hao Y, Zhao Y, Li D, Zhang B, Zhang Y, Zhang Z
    J Biomater Appl, 0;30(5):547-57.  0
  166. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
    Authors: Wang Y, An R, Umanah G, Park H, Nambiar K, Eacker S, Kim B, Bao L, Harraz M, Chang C, Chen R, Wang J, Kam T, Jeong J, Xie Z, Neifert S, Qian J, Andrabi S, Blackshaw S, Zhu H, Song H, Ming G, Dawson V, Dawson T
    Science, 0;354(6308):.  0
  167. Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.
    Authors: Kim J, Anurag M, Veeraraghavan J, Schiff R, Li K, Wang X
    Mol Cancer Res, 0;14(10):920-927.  0
  168. A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation.
    Authors: Hatano K, Kumar B, Zhang Y, Coulter J, Hedayati M, Mears B, Ni X, Kudrolli T, Chowdhury W, Rodriguez R, Deweese T, Lupold S
    Nucleic Acids Res, 0;43(8):4075-86.  0
  169. Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity.
    Authors: Butler K, Peeler D, Casey B, Dair B, Elespuru R
    Mutagenesis, 0;30(4):577-91.  0
  170. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-beta.
    Authors: Hardee M, Marciscano A, Medina-Ramirez C, Zagzag D, Narayana A, Lonning S, Barcellos-Hoff M
    Cancer Res, 0;72(16):4119-29.  0
  171. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency.
    Authors: Avagyan S, Churchill M, Yamamoto K, Crowe J, Li C, Lee B, Zheng T, Mukherjee S, Zha S
    Blood, 0;124(10):1622-5.  0
  172. Speckle-type POZ protein, SPOP, is involved in the DNA damage response.
    Authors: Zhang D, Wang H, Sun M, Yang J, Zhang W, Han S, Xu B
    Carcinogenesis, 0;35(8):1691-7.  0
  173. Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.
    Authors: Wei L, Griego A, Chu M, Ozbun M
    Carcinogenesis, 0;35(10):2373-81.  0
  174. Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
    Authors: Chen Y, Harris R, Hatahet Z, Chou K
    Proc Natl Acad Sci U S A, 0;112(33):E4556-64.  0
  175. Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity.
    Authors: Wagner W, Kania K, Ciszewski W
    DNA Repair (Amst), 0;52(0):49-58.  0
  176. Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage.
    Authors: Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M
    J Biochem, 0;159(2):225-37.  0
  177. Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.
    Authors: Weeks L, Fu P, Gerson S
    Mol Cancer Ther, 0;12(10):2248-60.  0
  178. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.
    Authors: Morales J, Richard P, Rommel A, Fattah F, Motea E, Patidar P, Xiao L, Leskov K, Wu S, Hittelman W, Chiang C, Manley J, Boothman D
    Nucleic Acids Res, 0;42(8):4996-5006.  0
  179. FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage.
    Authors: Bigarella C, Li J, Rimmele P, Liang R, Sobol R, Ghaffari S
    J Biol Chem, 0;292(7):3005-3015.  0
  180. DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice.
    Authors: Kyjovska Z, Jacobsen N, Saber A, Bengtson S, Jackson P, Wallin H, Vogel U
    Mutagenesis, 0;30(4):499-507.  0
  181. Inhibiting protein arginine deiminases has antioxidant consequences.
    Authors: Witalison E, Cui X, Hofseth A, Subramanian V, Causey C, Thompson P, Hofseth L
    J Pharmacol Exp Ther, 0;353(1):64-70.  0
  182. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
    Authors: Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, Zhang P
    Mol Cell Biol, 0;35(21):3657-68.  0
  183. Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
    Authors: Yu Z, Huang Y, Shieh S
    Nucleic Acids Res, 0;44(3):1133-50.  0
  184. Nuclear GIT2 is an ATM substrate and promotes DNA repair.
    Authors: Lu D, Cai H, Park S, Siddiqui S, Premont R, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon C, Martin B, Maudsley S
    Mol Cell Biol, 0;35(7):1081-96.  0
  185. CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.
    Authors: Iyama T, Lee S, Berquist B, Gileadi O, Bohr V, Seidman M, McHugh P, Wilson D
    Nucleic Acids Res, 0;43(1):247-58.  0
  186. Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.
    Authors: Verduzco D, Dovey J, Shukla A, Kodym E, Skaug B, Amatruda J
    Mol Cancer Res, 0;10(11):1451-61.  0
  187. Paternal DNA damage resulting from various sperm treatments persists after fertilization and is similar before and after DNA replication.
    Authors: Yamauchi Y, Riel J, Ward M
    J Androl, 0;33(2):229-38.  0
  188. Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.
    Authors: Sutherland J, Fraser B, Sobinoff A, Pye V, Davidson T, Siddall N, Koopman P, Hime G, McLaughlin E
    Biol Reprod, 0;90(5):92.  0
  189. HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.
    Authors: Sadik H, Korangath P, Nguyen N, Gyorffy B, Kumar R, Hedayati M, Teo W, Park S, Panday H, Munoz T, Menyhart O, Shah N, Pandita R, Chang J, Deweese T, Chang H, Pandita T, Sukumar S
    Cancer Res, 0;76(15):4443-56.  0
  190. Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
    Authors: Kim S, Jo S, Lee H, Kim T, Kim I, Yim J, Chung H
    Anticancer Res, 0;33(12):5445-51.  0
  191. hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.
    Authors: Paquet N, Adams M, Leong V, Ashton N, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess J, Bolderson E, O'Byrne K, Richard D
    Nucleic Acids Res, 0;43(18):8817-29.  0
  192. Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
    Authors: Liu C, Finke A, Diaz M, Rozhon W, Poppenberger B, Baubec T, Pecinka A
    Plant Cell, 0;27(6):1788-800.  0
  193. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.
    Authors: Goldstein M, Kastan M
    Cancer Res, 0;75(13):2699-707.  0
  194. Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
    Authors: Lu E, McLellan M, Ding L, Fulton R, Mardis E, Wilson R, Miller C, Westervelt P, DiPersio J, Link D, Walter M, Ley T, Graubert T
    Blood, 0;124(26):3887-95.  0
  195. Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
    Authors: Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B
    J Biol Chem, 0;290(48):28675-82.  0
  196. LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.
    Authors: Lehle S, Hildebrand D, Merz B, Malak P, Becker M, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O
    Nucleic Acids Res, 0;42(6):e41.  0
  197. PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.
    Authors: Yuan Z, Guo W, Yang J, Li L, Wang M, Lei Y, Wan Y, Zhao X, Luo N, Cheng P, Liu X, Nie C, Peng Y, Tong A, Wei Y
    J Biol Chem, 0;290(24):14927-44.  0
  198. Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation.
    Authors: Hedayati M, Haffner M, Coulter J, Raval R, Zhang Y, Zhou H, Mian O, Knight E, Razavi N, Dalrymple S, Isaacs J, Santos A, Hales R, Nelson W, Yegnasubramanian S, Deweese T
    Clin Cancer Res, 0;22(13):3310-3319.  0
  199. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
    Authors: Nguyen C, Possemato R, Bauerlein E, Xie A, Scully R, Hahn W
    Mol Cell Biol, 0;32(19):3963-77.  0
  200. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.
    Authors: Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston D
    Genes Dev, 0;27(20):2274-91.  0
  201. DNA Damage Response and DNA Repair in Skeletal Myocytes From a Mouse Model of Spinal Muscular Atrophy.
    Authors: Fayzullina S, Martin L
    J Neuropathol Exp Neurol, 0;75(9):889-902.  0
  202. Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.
    Authors: Karst A, Jones P, Vena N, Ligon A, Liu J, Hirsch M, Etemadmoghadam D, Bowtell D, Drapkin R
    Cancer Res, 0;74(4):1141-52.  0
  203. A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
    Authors: Nicolae C, Aho E, Choe K, Constantin D, Hu H, Lee D, Myung K, Moldovan G
    Nucleic Acids Res, 0;43(6):3143-53.  0
  204. The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.
    Authors: Thangavel C, Boopathi E, Ciment S, Liu Y, O'Neill R, Sharma A, McMahon S, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker A, Knudsen K, Den R
    Clin Cancer Res, 0;20(21):5468-5482.  0
  205. The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.
    Authors: De K, Bolanos-Villegas P, Mitra S, Yang X, Homan G, Jauh G, Makaroff C
    Plant Cell, 0;28(2):521-36.  0
  206. Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.
    Authors: Wakasugi M, Sasaki T, Matsumoto M, Nagaoka M, Inoue K, Inobe M, Horibata K, Tanaka K, Matsunaga T
    J Biol Chem, 0;289(41):28730-7.  0
  207. Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
    Authors: Efimova E, Takahashi S, Shamsi N, Wu D, Labay E, Ulanovskaya O, Weichselbaum R, Kozmin S, Kron S
    Mol Cancer Res, 0;14(2):173-84.  0
  208. ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
    Authors: Yang H, Palmbos P, Wang L, Kim E, Ney G, Liu C, Prasad J, Misek D, Yu X, Ljungman M, Simeone D
    J Biol Chem, 0;290(45):27146-57.  0
  209. ATM regulates NF-kappaB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
    Authors: Fang L, Choudhary S, Zhao Y, Edeh C, Yang C, Boldogh I, Brasier A
    Nucleic Acids Res, 0;42(13):8416-32.  0
  210. Human papillomavirus type 16 E6* induces oxidative stress and DNA damage.
    Authors: Williams V, Filippova M, Filippov V, Payne K, Duerksen-Hughes P
    J Virol, 0;88(12):6751-61.  0
  211. Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication.
    Authors: Baer A, Austin D, Narayanan A, Popova T, Kainulainen M, Bailey C, Kashanchi F, Weber F, Kehn-Hall K
    J Biol Chem, 0;287(10):7399-410.  0
  212. The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition.
    Authors: Chatterjee P, Choudhary G, Alswillah T, Xiong X, Heston W, Magi-Galluzzi C, Zhang J, Klein E, Almasan A
    Mol Cancer Ther, 0;14(8):1896-906.  0
  213. Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.
    Authors: Maruyama C, Leigh N, Nelson J, McCall A, Mellas R, Lei P, Andreadis S, Baker O
    J Dent Res, 0;94(11):1610-7.  0
  214. XPD-dependent activation of apoptosis in response to triplex-induced DNA damage.
    Authors: Kaushik Tiwari M, Rogers F
    Nucleic Acids Res, 0;41(19):8979-94.  0
  215. Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
    Authors: Ming J, Sun B, Li Z, Lin L, Meng X, Han B, Wang R, Wu P, Li J, Cai J, Jiang C
    Aging (Albany NY), 0;9(4):1233-1247.  0
  216. WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.
    Authors: Abu-Odeh M, Salah Z, Herbel C, Hofmann T, Aqeilan R
    Proc Natl Acad Sci U S A, 0;111(44):E4716-25.  0
  217. PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.
    Authors: Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger M
    Nucleic Acids Res, 0;44(16):7630-45.  0
  218. Overexpression of HPV16 E6* Alters beta-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells.
    Authors: Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves M, Duerksen-Hughes P
    Cancer Genomics Proteomics, 0;13(4):259-73.  0
  219. Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
    Authors: Matsuda S, Matsuda Y, Yanagisawa S, Ikura M, Ikura T, Matsuda T
    Toxicol Sci, 0;151(2):224-35.  0
  220. Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study.
    Authors: Duan H, Jia X, Zhai Q, Ma L, Wang S, Huang C, Wang H, Niu Y, Li X, Dai Y, Yu S, Gao W, Chen W, Zheng Y
    Occup Environ Med, 0;73(2):83-90.  0
  221. miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells.
    Authors: Huang S, Yang Z, Ma Y, Yang Y, Wang S
    DNA Cell Biol, 0;36(4):303-310.  0
  222. Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis.
    Authors: Di Simone N, De Spirito M, Di Nicuolo F, Tersigni C, Castellani R, Silano M, Maulucci G, Papi M, Marana R, Scambia G, Gasbarrini A
    Biol Reprod, 0;89(4):88.  0
  223. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
    Authors: Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J
    Mol Cell Biol, 0;33(24):4960-70.  0
  224. Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.
    Authors: Brachova P, Alvarez N, Van Voorhis B, Christenson L
    Gynecol Oncol, 0;145(3):577-583.  0
  225. A hormone-DNA repair circuit governs the response to genotoxic insult.
    Authors: Goodwin J, Schiewer M, Dean J, Schrecengost R, de Leeuw R, Han S, Ma T, Den R, Dicker A, Feng F, Knudsen K
    Cancer Discov, 0;3(11):1254-71.  0
  226. HT-COMET: a novel automated approach for high throughput assessment of human sperm chromatin quality.
    Authors: Albert O, Reintsch W, Chan P, Robaire B
    Hum Reprod, 0;31(5):938-46.  0
  227. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.
    Authors: Buckel L, Savariar E, Crisp J, Jones K, Hicks A, Scanderbeg D, Nguyen Q, Sicklick J, Lowy A, Tsien R, Advani S
    Cancer Res, 0;75(7):1376-1387.  0
  228. Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
    Authors: Cleaver J, Brennan-Minnella A, Swanson R, Fong K, Chen J, Chou K, Chen Y, Revet I, Bezrookove V
    Proc Natl Acad Sci U S A, 0;111(37):13487-92.  0
  229. BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.
    Authors: Qi W, Wang R, Chen H, Wang X, Xiao T, Boldogh I, Ba X, Han L, Zeng X
    J Cell Sci, 0;128(2):317-30.  0
  230. Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
    Authors: Li Y, Armstrong R, Duronio R, MacAlpine D
    Nucleic Acids Res, 0;44(15):7204-18.  0
  231. Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages.
    Authors: Garbati M, Hays L, Rathbun R, Jillette N, Chin K, Al-Dhalimy M, Agarwal A, Newell A, Olson S, Bagby G
    J Leukoc Biol, 0;99(3):455-65.  0
  232. Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-kappaB pathway.
    Authors: Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra T, Mitra S, Sur S, Brasier A, Ba X, Boldogh I
    J Immunol, 0;193(9):4643-53.  0
  233. Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks.
    Authors: Matsuoka K, Iimori M, Niimi S, Tsukihara H, Watanabe S, Kiyonari S, Kiniwa M, Ando K, Tokunaga E, Saeki H, Oki E, Maehara Y, Kitao H
    Mol Cancer Ther, 0;14(4):1004-13.  0
  234. Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells.
    Authors: Jeon H, Yi J, Kim T, Oh Y, Lee H, Lee M, Bang J, Ko K, Ahn I, Ko K, Kim J, Park H, Lee J, Sohn S
    Toxicol Res, 0;33(2):107-118.  0
  235. PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
    Authors: Cheng X, Byrne M, Brown K, Konopleva M, Kornblau S, Bennett R, May W
    Blood, 0;126(13):1585-94.  0
  236. The Role of HMGB1 in Radioresistance of Bladder Cancer.
    Authors: Shrivastava S, Mansure J, Almajed W, Cury F, Ferbeyre G, Popovic M, Seuntjens J, Kassouf W
    Mol Cancer Ther, 0;15(3):471-9.  0
  237. Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells.
    Authors: Li D, Cao W
    Am J Physiol Gastrointest Liver Physiol, 0;306(10):G863-72.  0
  238. Doxorubicin and vincristine affect undifferentiated rat spermatogonia.
    Authors: Beaud H, van Pelt A, Delbes G
    Reproduction, 0;153(6):725-735.  0
  239. Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.
    Authors: Martinez T, Phillips J, Karanja K, Polaczek P, Wang C, Li B, Campbell J, Dervan P
    Nucleic Acids Res, 0;42(18):11546-59.  0
  240. Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.
    Authors: Ishida N, Nakagawa T, Iemura S, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K
    Mol Cell Biol, 0;37(4):.  0
  241. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.
    Authors: Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O
    Nucleic Acids Res, 0;0(0):.  0
  242. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
    Authors: Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman M, Greenberg R
    Genes Dev, 0;29(18):1955-68.  0
  243. The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.
    Authors: Donninger H, Clark J, Rinaldo F, Nelson N, Barnoud T, Schmidt M, Hobbing K, Vos M, Sils B, Clark G
    Mol Cell Biol, 0;35(1):277-87.  0
  244. Thirdhand smoke causes DNA damage in human cells.
    Authors: Hang B, Sarker A, Havel C, Saha S, Hazra T, Schick S, Jacob P, Rehan V, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel L
    Mutagenesis, 0;28(4):381-91.  0
  245. Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.
    Authors: Scanlon S, Glazer P
    Mol Cancer Res, 0;12(7):1016-28.  0
  246. Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.
    Authors: Kaushik Tiwari M, Adaku N, Peart N, Rogers F
    Nucleic Acids Res, 0;44(16):7742-54.  0
  247. Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
    Authors: Boichuk S, Lee D, Mehalek K, Makielski K, Wozniak A, Seneviratne D, Korzeniewski N, Cuevas R, Parry J, Brown M, Zewe J, Taguchi T, Kuan S, Schoffski P, Debiec-Rychter M, Duensing A
    Cancer Res, 0;74(4):1200-13.  0
  248. Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer.
    Authors: Ziebarth A, Nowsheen S, Steg A, Shah M, Katre A, Dobbin Z, Han H, Lopez-Berestein G, Sood A, Conner M, Yang E, Landen C
    Clin Cancer Res, 0;19(1):170-82.  0
  249. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
    Authors: Yang Y, Durando M, Smith-Roe S, Sproul C, Greenwalt A, Kaufmann W, Oh S, Hendrickson E, Vaziri C
    Nucleic Acids Res, 0;41(4):2296-312.  0
  250. Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
    Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
    Mutagenesis, 0;28(6):653-60.  0
  251. Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
    Authors: McLaughlin D, Coey C, Yang W, Drohat A, Matunis M
    J Biol Chem, 0;291(17):9014-24.  0
  252. Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
    Authors: Garcia K, Blank J, Bouck D, Liu X, Sappal D, Hather G, Cosmopoulos K, Thomas M, Kuranda M, Pickard M, Liu R, Bandi S, Smith P, Lightcap E
    Mol Cancer Ther, 0;13(6):1625-35.  0
  253. Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
    Authors: Proia D, Zhang C, Sequeira M, Jimenez J, He S, Spector N, Shapiro G, Tolaney S, Nagai M, Acquaviva J, Smith D, Sang J, Bates R, El-Hariry I
    Clin Cancer Res, 0;20(2):413-24.  0
  254. A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
    Authors: Feng Z, Zhang J
    Nucleic Acids Res, 0;40(2):726-38.  0
  255. c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.
    Authors: Luo H, Chen Z, Wang S, Zhang R, Qiu W, Zhao L, Peng C, Xu R, Chen W, Wang H, Chen Y, Yang J, Zhang X, Zhang S, Chen D, Wu W, Zhao C, Cheng G, Jiang T, Lu D, You Y, Liu N, Wang H
    Brain, 0;138(0):3654-72.  0
  256. Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
    Authors: Liu G, Yang D, Rupaimoole R, Pecot C, Sun Y, Mangala L, Li X, Ji P, Cogdell D, Hu L, Wang Y, Rodriguez-Aguayo C, Lopez-Berestein G, Shmulevich I, De Cecco L, Chen K, Mezzanzanica D, Xue F, Sood A, Zhang W
    J Natl Cancer Inst, 0;107(7):.  0
  257. Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
    Authors: Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S
    Mol Pharmacol, 0;82(6):1030-41.  0
  258. Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
    Authors: Lancini C, van den Berk P, Vissers J, Gargiulo G, Song J, Hulsman D, Serresi M, Tanger E, Blom M, Vens C, van Lohuizen M, Jacobs H, Citterio E
    J Exp Med, 0;211(9):1759-77.  0
  259. Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells.
    Authors: Reelfs O, Macpherson P, Ren X, Xu Y, Karran P, Young A
    Nucleic Acids Res, 0;39(22):9620-32.  0
  260. A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles.
    Authors: Stoccoro A, Di Bucchianico S, Uboldi C, Coppede F, Ponti J, Placidi C, Blosi M, Ortelli S, Costa A, Migliore L
    Mutagenesis, 0;31(5):511-29.  0
  261. NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
    Authors: Li L, Reddy S, Lin Z, Liu S, Park H, Chun S, Bornmann W, Thibodeaux J, Yan J, Chakrabarti G, Xie X, Sumer B, Boothman D, Yordy J
    Mol Cancer Ther, 0;15(7):1757-67.  0
  262. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
    Authors: Kanai R, Rabkin S, Yip S, Sgubin D, Zaupa C, Hirose Y, Louis D, Wakimoto H, Martuza R
    J Natl Cancer Inst, 0;104(1):42-55.  0
  263. USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance.
    Authors: Lee J, Chang N, Yoon Y, Yang H, Cho H, Kim E, Shin Y, Kang W, Oh Y, Mun G, Joo K, Nam D, Lee J
    Neuro Oncol, 0;18(1):37-47.  0
  264. 2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF.
    Authors: Shen W, Liang X, Sun H, Crooke S
    Nucleic Acids Res, 0;43(9):4569-78.  0
  265. UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation.
    Authors: Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama K, Ogura H, Shiiya N, Kitagawa M
    Mol Cell Biol, 0;36(3):394-406.  0

FAQs

  1. Are there other dyes beside SYBR Gold that can be used in the Comet Assay?

    • Yes, other dyes that can be substituted for SYBR Gold in staining solution for the Comet Assay. The important parameters to consider in choosing a DNA stain for the comet assay are similar fluorescence and decay rates for single-and  double-strand DNA. See Appendix C in the product insert for a table of DNA stains parameters. R&D Systems selected SYBR Gold dye due to the high background to noise ratio. It is the responsibility of the end-users to optimize the use of an alternative dye chosen for the Comet Assay.

View all FAQs

Reviews for CometAssay Single Cell Gel Electrophoresis Assay

There are currently no reviews for this product. Be the first to review CometAssay Single Cell Gel Electrophoresis Assay and earn rewards!

Have you used CometAssay Single Cell Gel Electrophoresis Assay?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review