CometAssay Single Cell Gel Electrophoresis Assay

Catalog # Availability Size / Price Qty
4250-050-K
Product Details
Citations (255)
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CometAssay Single Cell Gel Electrophoresis Assay Summary

Includes twenty-five specially treated CometSlides (2 Well) and sufficient reagents for 50 test samples.

Key Benefits

• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions

Product Specifications

  • Applicable for the analysis of either single- or double-strand DNA breaks
  • Study cellular responses to DNA damage
  • Screen for inhibitors of DNA repair
  • Test chemicals for toxicity
  • Screen for environmental mutagens

What is the CometAssay?

The Comet assay, or single cell gel electrophoresis assay, provides a simple and effective method for evaluating DNA damage in cells. The principle of the assay is based upon the ability of denatured, cleaved DNA fragments to migrate out of the nucleoid under the influence of an electric field, whereas undamaged DNA migrates slower and remains within the confines of the nucleoid when a current is applied. Evaluation of the DNA “comet” tail shape and migration pattern allows for assessment of DNA damage. The general Comet assay protocol includes first immobilizing cells in a bed of low melting point agarose, gently lysing the cells, treating cells with neutral or alkali solutions to unwind and denature the DNA as well as hydrolyze sites of damage. DNA is then subjected to electrophoresis and stained with a fluorescent DNA intercalating dye.

Kit Contents

• CometAssay Lysis Solution
• CometAssay LMAgarose
• CometSlides (2 Well, 25 Slides)
• 200 mM EDTA, pH 10

Specifications

Shipping Conditions
The product is shipped ambient or with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store products immediately at the temperature recommended on the product labels.
Species
N/A

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Citations for CometAssay Single Cell Gel Electrophoresis Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

255 Citations: Showing 1 - 10
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  1. 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
    Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
    Mar Drugs, 2020;18(8):.  2020
  2. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
    Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
    Theranostics, 2020;10(7):3351-3365.  2020
  3. Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
    Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
    Molecules, 2020;25(5):.  2020
  4. Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
    Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
    Sci Rep, 2020;10(1):4943.  2020
  5. Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
    Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
    Front Pharmacol, 2020;11(0):263.  2020
  6. Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
    Authors: E Kong, HD Kim, J Kim
    Cell Death Differ., 2020;0(0):.  2020
  7. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
    Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
    Cell Rep, 2020;31(2):107518.  2020
  8. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
    Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
    EMBO Mol Med, 2020;12(6):e10622.  2020
  9. Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
    Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
    Nucleic Acids Res., 2020;0(0):.  2020
  10. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
    Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
    PLoS Genet., 2020;16(1):e1008558.  2020
  11. Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
    Authors: X Wang, X Chen, L Sun, W Qian
    PLoS Genet., 2019;15(4):e1008094.  2019
  12. Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
    Authors: M Cucè, ME Gallo Cant, MA Siciliano, C Riillo, D Caracciolo, F Scionti, N Staropoli, V Zuccalà, L Maltese, A Di Vito, K Grillone, V Barbieri, M Arbitrio, MT Di Martino, M Rossi, N Amodio, P Tagliaferr, P Tassone, C Botta
    J Hematol Oncol, 2019;12(1):32.  2019
  13. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019;10(4):274.  2019
  14. MiR-34s negatively regulate homologous recombination through targeting RAD51
    Authors: S Chen, R Liu, Q Wang, Z Qi, Y Hu, P Zhou, Z Wang
    Arch. Biochem. Biophys., 2019;666(0):73-82.  2019
  15. The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
    Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
    Int J Mol Sci, 2019;20(8):.  2019
  16. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
    Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
    Cell Stem Cell, 2019;0(0):.  2019
  17. PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells
    Authors: B Liu, L Lin, S Riazuddin, A Zubair, L Wang, LJ Di, R Li, TT Dong, CX Deng, WM Tong
    Int. J. Biochem. Cell Biol., 2019;109(0):40-58.  2019
  18. PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
    Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
    Cell Rep, 2019;26(5):1333-1343.e7.  2019
  19. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
    Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
    Acta Neuropathol Commun, 2019;7(1):77.  2019
  20. OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
    Authors: Z Wu, M Qiu, Y Guo, J Zhao, Z Liu, H Wang, M Meng, Z Yuan, Z Mi
    Cancer Cell Int., 2019;19(0):99.  2019
  21. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis
    Authors: HJ Wen, S Gao, Y Wang, M Ray, MA Magnuson, CVE Wright, MP Di Maglian, TL Frankel, HC Crawford
    Cell Mol Gastroenterol Hepatol, 2019;0(0):.  2019
  22. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
    Authors: N Martinez-V, M Marigil, M García-Mou, M Gonzalez-H, JJ Aristu, LI Ramos-Garc, S Tejada, R Díez-Valle, A Patiño-Gar, OJ Becher, C Gomez-Manz, J Fueyo, MM Alonso
    Acta Neuropathol Commun, 2019;7(1):64.  2019
  23. ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy
    Authors: MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, G Falkous, D Williams, P Cox, A Meynert, ES Raymond, H Morrison, S Brown, E Allan, I Aligianis, AP Jackson, BH Ramsahoye, A von Kriegs, RW Taylor, AJ Finch, DR FitzPatric
    PLoS Genet., 2019;15(3):e1007605.  2019
  24. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
    Authors: A Chaiprason, Z Janjetovic, TK Kim, SG Jarrett, JA D'Orazio, MF Holick, EKY Tang, RC Tuckey, U Panich, W Li, AT Slominski
    Redox Biol, 2019;24(0):101206.  2019
  25. Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
    Authors: A Wilson, V Menon, Z Khan, A Alam, L Litovchick, V Yakovlev
    Redox Biol, 2019;24(0):101169.  2019
  26. Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
    Authors: Z Qi, Y Song, Q Ding, X Liao, R Li, G Liu, S Tsang, Z Cai
    Ecotoxicol. Environ. Saf., 2019;168(0):378-387.  2019
  27. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
    Authors: D Zhang, X Hu, J Li, J Liu, L Baks-Te Bu, M Wiersma, NU Malik, DMS van Marion, M Tolouee, F Hoogstra-B, EAH Lanters, AM van Roon, AAF de Vries, DA Pijnappels, NMS de Groot, RH Henning, BJJM Brundel
    Nat Commun, 2019;10(1):1307.  2019
  28. Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica
    Authors: X Shao, B Zhao, B Wang, B Zhao, Y Zhu, Z Yuan, J Zhang
    Ecotoxicol. Environ. Saf., 2019;175(0):39-47.  2019
  29. A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
    Authors: M Wu, Y Wang, D Yang, Y Gong, F Rao, R Liu, Y Danna, J Li, J Fan, J Chen, W Zhang, Q Zhan
    EBioMedicine, 2019;0(0):.  2019
  30. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
    Authors: G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka, AC Barros, M Woods, B Fu, F Yang, E Chen, M Ostermaier, T Stankovic, H Ponstingl, M Herzog, K Yusa, FM Martinez, ST Durant, Y Galanty, P Beli, DJ Adams, A Bradley, E Metzakopia, JV Forment, SP Jackson
    Nat Commun, 2019;10(1):87.  2019
  31. miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis
    Authors: J Tao, M Fan, D Zhou, Y Hong, J Zhang, H Liu, S Sharma, G Wang, Q Dong
    Oxid Med Cell Longev, 2019;2019(0):2352079.  2019
  32. MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1
    Authors: Y Dai, X Lin, W Xu, X Lin, Q Huang, L Shi, Y Pan, Y Zhang, Y Zhu, C Li, L Liu, S Zhang
    Cell Death Dis, 2019;10(2):144.  2019
  33. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
    Authors: J Wang, B Chan, M Tong, Y Paung, U Jo, D Martin, M Seeliger, J Haley, H Kim
    PLoS Genet., 2019;15(2):e1007983.  2019
  34. Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes
    Authors: S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang
    Cell Rep, 2019;26(8):2194-2211.e6.  2019
  35. Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
    Authors: T Lin, TC Lin, DJ McGrail, PK Bhupal, YH Ku, W Zhang, L Meng, SY Lin, G Peng, RYL Tsai
    Oncogene, 2019;0(0):.  2019
  36. Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
    Authors: E Lee, H Jeon, M Lee, J Ryu, C Kang, S Kim, J Jung, Y Kwon
    Sci Rep, 2019;9(1):2494.  2019
  37. Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
    Authors: FJ Chou, Y Chen, D Chen, Y Niu, G Li, P Keng, S Yeh, C Chang
    EBioMedicine, 2019;0(0):.  2019
  38. Molecular damage and responses of oral keratinocyte to hydrogen peroxide
    Authors: KY Lin, CH Chung, JS Ciou, PF Su, PW Wang, DB Shieh, TC Wang
    BMC Oral Health, 2019;19(1):10.  2019
  39. PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
    Authors: C Lv, S Fu, Q Dong, Z Yu, G Zhang, C Kong, C Fu, Y Zeng
    J. Exp. Clin. Cancer Res., 2019;38(1):24.  2019
  40. Epithelial?mesenchymal transition induced by bone morphogenetic protein 9 hinders cisplatin efficacy in ovarian cancer cells
    Authors: Y Wang, B Yang, J Zhao, X Yu, X Liu, L Zhang, Y Zhang, X Li, Z Zhai
    Mol Med Rep, 2019;0(0):.  2019
  41. Promotion of homology-directed DNA repair by polyamines
    Authors: CY Lee, GC Su, WY Huang, MY Ko, HY Yeh, GD Chang, SJ Lin, P Chi
    Nat Commun, 2019;10(1):65.  2019
  42. A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells
    Authors: J Jiang, N Mao, H Hu, J Tang, D Han, S Liu, Q Wu, Y Liu, C Peng, J Lai, C Yang
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.  2019
  43. miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC? and ZEB1 inhibition
    Authors: R El Bezawy, S Tinelli, M Tortoreto, V Doldi, V Zuco, M Folini, C Stucchi, T Rancati, R Valdagni, P Gandellini, N Zaffaroni
    J. Exp. Clin. Cancer Res., 2019;38(1):51.  2019
  44. Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
    Authors: P Nagarajan, PA Agudelo Ga, CC Iyer, LV Popova, WD Arnold, MR Parthun
    Aging Cell, 2019;0(0):e12992.  2019
  45. Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
    Authors: M Hong, J Li, S Li, M M Almutair
    Cells, 2019;8(11):.  2019
  46. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
    Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
    Sci Rep, 2019;9(1):19035.  2019
  47. ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
    Authors: SH Park, N Kang, E Song, M Wie, EA Lee, S Hwang, D Lee, JS Ra, IB Park, J Park, S Kang, JH Park, S Hohng, KY Lee, K Myung
    Nat Commun, 2019;10(1):5718.  2019
  48. IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
    Authors: J Panneersel, A Srivastava, M Mehta, A Chen, YD Zhao, A Munshi, R Ramesh
    Cancers (Basel), 2019;11(12):.  2019
  49. Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
    Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
    Nat Commun, 2019;10(1):5349.  2019
  50. Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
    Authors: G Urrutia, A Salmonson, JA Toro-Zapat, TM de Assunca, A Mathison, N Dusetti, J Iovanna, R Urrutia, G Lomberk
    Mol. Cancer Res., 2019;0(0):.  2019
  51. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
    Authors: D Andrade, M Mehta, J Griffith, S Oh, J Corbin, A Babu, S De, A Chen, YD Zhao, S Husain, S Roy, L Xu, J Aube, R Janknecht, M Gorospe, T Herman, R Ramesh, A Munshi
    Cancers (Basel), 2019;11(12):.  2019
  52. Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
    Authors: S Zhang, J Zhang, W Cheng, H Chen, A Wang, Y Liu, H Hou, Q Hu
    Chemosphere, 2019;244(0):125482.  2019
  53. Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
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    Cell Discov, 2019;5(0):47.  2019
  54. Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
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    J. Exp. Clin. Cancer Res., 2019;38(1):499.  2019
  55. Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response
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    DNA Repair (Amst.), 2019;85(0):102737.  2019
  56. Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
    Authors: S Giovannini, MC Weller, S Repmann, H Moch, J Jiricny
    Nucleic Acids Res., 2019;0(0):.  2019
  57. APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
    Authors: CD Stefanski, K Keffler, S McClintock, L Milac, JR Prosperi
    Neoplasia, 2019;21(12):1143-1150.  2019
  58. Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
    Authors: DS Metselaar, MH Meel, B Benedict, P Waranecki, J Koster, GJL Kaspers, E Hulleman
    EBioMedicine, 2019;0(0):.  2019
  59. Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma
    Authors: AM Robinson, R Rathore, NJ Redlich, DR Adkins, T VanArsdale, BA Van Tine, LS Michel
    Cell Death Dis, 2019;10(11):867.  2019
  60. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts
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  61. BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
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    Autophagy, 2019;0(0):1-18.  2019
  62. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
    Authors: AL Perl, CM O'Connor, P Fa, F Mayca Pozo, J Zhang, Y Zhang, G Narla
    J. Biol. Chem., 2019;0(0):.  2019
  63. Male mice, caged in the International Space Station for 35 days, sire healthy offspring
    Authors: T Matsumura, T Noda, M Muratani, R Okada, M Yamane, A Isotani, T Kudo, S Takahashi, M Ikawa
    Sci Rep, 2019;9(1):13733.  2019
  64. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
    Authors: JP Cebrià-Cos, L Pascual-Re, A Gonzalez-P, G Serra-Bard, J Querol, M Cosín, G Verde, RA Cigliano, W Sanseverin, S Segura-Bay, A Iturbide, D Andreu, P Nuciforo, C Bernado-Mo, V Rodilla, J Arribas, J Yelamos, AG de Herrero, TH Stracker, S Peiró
    Oncogene, 2019;0(0):.  2019
  65. Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
    Authors: Y Zhou, Y Xu, L Lu, J Ni, J Nie, J Cao, Y Jiao, Q Zhang
    Theranostics, 2019;9(22):6665-6675.  2019
  66. Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells
    Authors: A Kopacz, D Klóska, B Proniewski, D Cysewski, N Personnic, A Piechota-P, P Kaczara, A Zakrzewska, HJ Forman, J Dulak, A Józkowicz, A Grochot-Pr
    Redox Biol, 2019;28(0):101304.  2019
  67. Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
    Authors: S Lin, L Yu, X Song, J Bi, L Jiang, Y Wang, M He, Q Xiao, M Sun, OI Olopade, L Zhao, M Wei
    Cell Death Dis, 2019;10(9):666.  2019
  68. Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
    Authors: C Mani, S Jonnalagad, J Lingareddy, S Awasthi, WH Gmeiner, K Palle
    Breast Cancer Res., 2019;21(1):104.  2019
  69. TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
    Authors: J Chen, Z Wang, X Guo, F Li, Q Wei, X Chen, D Gong, Y Xu, W Chen, Y Liu, J Kang, Y Shi
    Nat Commun, 2019;10(1):4273.  2019
  70. Precision Chemo-Radiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
    Authors: DV Hingorani, MK Doan, MF Camargo, J Aguilera, SM Song, D Pizzo, DJ Scanderbeg, EEW Cohen, AM Lowy, SR Adams, SJ Advani
    Mol. Cancer Ther., 2019;0(0):.  2019
  71. The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas
    Authors: F Valenti, A Sacconi, F Ganci, G Grasso, S Strano, G Blandino, S Di Agostin
    Cancers (Basel), 2019;11(9):.  2019
  72. Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
    Authors: A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, P Calsou, Y Pommier, G Favre, G Capranico, N Gromak, O Sordet
    Cell Rep, 2019;28(12):3167-3181.e6.  2019
  73. Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia
    Authors: SEF Kost, A Saleh, EM Mejia, M Mostafizar, EDJ Bouchard, V Banerji, AJ Marshall, SB Gibson, JB Johnston, S Katyal
    Cancers (Basel), 2019;11(10):.  2019
  74. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
    Authors: X Xiao, J Liang, C Huang, K Li, F Xing, W Zhu, Z Lin, W Xu, G Wu, J Zhang, X Lin, Y Tan, J Cai, J Hu, X Chen, Y Huang, Z Qin, P Qiu, X Su, L Chen, Y Lin, H Zhang, G Yan
    Nat Commun, 2018;9(1):4342.  2018
  75. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
    Authors: D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha
    Nat Commun, 2018;9(1):5351.  2018
  76. Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.
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    Blood, 2015;126(26):2821-31.  2015
  77. Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism.
    Authors: Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J
    Cancer Res, 2015;75(13):2663-73.  2015
  78. Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
    Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
    J Pharmacol Exp Ther, 2014;348(3):360-71.  2014
  79. CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
    Authors: Shibata E, Dar A, Dutta A
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