CometAssay Single Cell Gel Electrophoresis Assay
CometAssay Single Cell Gel Electrophoresis Assay Summary
Key Benefits
• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions
Product Specifications
- Applicable for the analysis of either single- or double-strand DNA breaks
- Study cellular responses to DNA damage
- Screen for inhibitors of DNA repair
- Test chemicals for toxicity
- Screen for environmental mutagens
What is the CometAssay?
The Comet assay, or single cell gel electrophoresis assay, provides a simple and effective method for evaluating DNA damage in cells. The principle of the assay is based upon the ability of denatured, cleaved DNA fragments to migrate out of the nucleoid under the influence of an electric field, whereas undamaged DNA migrates slower and remains within the confines of the nucleoid when a current is applied. Evaluation of the DNA “comet” tail shape and migration pattern allows for assessment of DNA damage. The general Comet assay protocol includes first immobilizing cells in a bed of low melting point agarose, gently lysing the cells, treating cells with neutral or alkali solutions to unwind and denature the DNA as well as hydrolyze sites of damage. DNA is then subjected to electrophoresis and stained with a fluorescent DNA intercalating dye.
Kit Contents
• CometAssay Lysis Solution
• CometAssay LMAgarose
• CometSlides (2 Well, 25 Slides)
• 200 mM EDTA, pH 10
Specifications
Limitations
For research use only. Not for diagnositic use.
Product Datasheets
Citations for CometAssay Single Cell Gel Electrophoresis Assay
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
Mar Drugs, 2020;18(8):. 2020
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ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
Theranostics, 2020;10(7):3351-3365. 2020
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Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
Molecules, 2020;25(5):. 2020
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Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
Sci Rep, 2020;10(1):4943. 2020
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Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
Front Pharmacol, 2020;11(0):263. 2020
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Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
Authors: E Kong, HD Kim, J Kim
Cell Death Differ., 2020;0(0):. 2020
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Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
Cell Rep, 2020;31(2):107518. 2020
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HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
EMBO Mol Med, 2020;12(6):e10622. 2020
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Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
Nucleic Acids Res., 2020;0(0):. 2020
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Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
PLoS Genet., 2020;16(1):e1008558. 2020
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Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
Authors: X Wang, X Chen, L Sun, W Qian
PLoS Genet., 2019;15(4):e1008094. 2019
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Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
Authors: M Cucè, ME Gallo Cant, MA Siciliano, C Riillo, D Caracciolo, F Scionti, N Staropoli, V Zuccalà, L Maltese, A Di Vito, K Grillone, V Barbieri, M Arbitrio, MT Di Martino, M Rossi, N Amodio, P Tagliaferr, P Tassone, C Botta
J Hematol Oncol, 2019;12(1):32. 2019
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Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
Cell Death Dis, 2019;10(4):274. 2019
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MiR-34s negatively regulate homologous recombination through targeting RAD51
Authors: S Chen, R Liu, Q Wang, Z Qi, Y Hu, P Zhou, Z Wang
Arch. Biochem. Biophys., 2019;666(0):73-82. 2019
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The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
Int J Mol Sci, 2019;20(8):. 2019
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Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
Cell Stem Cell, 2019;0(0):. 2019
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PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells
Authors: B Liu, L Lin, S Riazuddin, A Zubair, L Wang, LJ Di, R Li, TT Dong, CX Deng, WM Tong
Int. J. Biochem. Cell Biol., 2019;109(0):40-58. 2019
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PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
Cell Rep, 2019;26(5):1333-1343.e7. 2019
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Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
Acta Neuropathol Commun, 2019;7(1):77. 2019
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OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
Authors: Z Wu, M Qiu, Y Guo, J Zhao, Z Liu, H Wang, M Meng, Z Yuan, Z Mi
Cancer Cell Int., 2019;19(0):99. 2019
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Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis
Authors: HJ Wen, S Gao, Y Wang, M Ray, MA Magnuson, CVE Wright, MP Di Maglian, TL Frankel, HC Crawford
Cell Mol Gastroenterol Hepatol, 2019;0(0):. 2019
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Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
Authors: N Martinez-V, M Marigil, M García-Mou, M Gonzalez-H, JJ Aristu, LI Ramos-Garc, S Tejada, R Díez-Valle, A Patiño-Gar, OJ Becher, C Gomez-Manz, J Fueyo, MM Alonso
Acta Neuropathol Commun, 2019;7(1):64. 2019
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ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy
Authors: MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, G Falkous, D Williams, P Cox, A Meynert, ES Raymond, H Morrison, S Brown, E Allan, I Aligianis, AP Jackson, BH Ramsahoye, A von Kriegs, RW Taylor, AJ Finch, DR FitzPatric
PLoS Genet., 2019;15(3):e1007605. 2019
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Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
Authors: A Chaiprason, Z Janjetovic, TK Kim, SG Jarrett, JA D'Orazio, MF Holick, EKY Tang, RC Tuckey, U Panich, W Li, AT Slominski
Redox Biol, 2019;24(0):101206. 2019
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Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
Authors: A Wilson, V Menon, Z Khan, A Alam, L Litovchick, V Yakovlev
Redox Biol, 2019;24(0):101169. 2019
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Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
Authors: Z Qi, Y Song, Q Ding, X Liao, R Li, G Liu, S Tsang, Z Cai
Ecotoxicol. Environ. Saf., 2019;168(0):378-387. 2019
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DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
Authors: D Zhang, X Hu, J Li, J Liu, L Baks-Te Bu, M Wiersma, NU Malik, DMS van Marion, M Tolouee, F Hoogstra-B, EAH Lanters, AM van Roon, AAF de Vries, DA Pijnappels, NMS de Groot, RH Henning, BJJM Brundel
Nat Commun, 2019;10(1):1307. 2019
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Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica
Authors: X Shao, B Zhao, B Wang, B Zhao, Y Zhu, Z Yuan, J Zhang
Ecotoxicol. Environ. Saf., 2019;175(0):39-47. 2019
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A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
Authors: M Wu, Y Wang, D Yang, Y Gong, F Rao, R Liu, Y Danna, J Li, J Fan, J Chen, W Zhang, Q Zhan
EBioMedicine, 2019;0(0):. 2019
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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Authors: G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka, AC Barros, M Woods, B Fu, F Yang, E Chen, M Ostermaier, T Stankovic, H Ponstingl, M Herzog, K Yusa, FM Martinez, ST Durant, Y Galanty, P Beli, DJ Adams, A Bradley, E Metzakopia, JV Forment, SP Jackson
Nat Commun, 2019;10(1):87. 2019
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miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis
Authors: J Tao, M Fan, D Zhou, Y Hong, J Zhang, H Liu, S Sharma, G Wang, Q Dong
Oxid Med Cell Longev, 2019;2019(0):2352079. 2019
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MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1
Authors: Y Dai, X Lin, W Xu, X Lin, Q Huang, L Shi, Y Pan, Y Zhang, Y Zhu, C Li, L Liu, S Zhang
Cell Death Dis, 2019;10(2):144. 2019
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Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
Authors: J Wang, B Chan, M Tong, Y Paung, U Jo, D Martin, M Seeliger, J Haley, H Kim
PLoS Genet., 2019;15(2):e1007983. 2019
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Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes
Authors: S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang
Cell Rep, 2019;26(8):2194-2211.e6. 2019
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Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
Authors: T Lin, TC Lin, DJ McGrail, PK Bhupal, YH Ku, W Zhang, L Meng, SY Lin, G Peng, RYL Tsai
Oncogene, 2019;0(0):. 2019
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Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
Authors: E Lee, H Jeon, M Lee, J Ryu, C Kang, S Kim, J Jung, Y Kwon
Sci Rep, 2019;9(1):2494. 2019
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Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
Authors: FJ Chou, Y Chen, D Chen, Y Niu, G Li, P Keng, S Yeh, C Chang
EBioMedicine, 2019;0(0):. 2019
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Molecular damage and responses of oral keratinocyte to hydrogen peroxide
Authors: KY Lin, CH Chung, JS Ciou, PF Su, PW Wang, DB Shieh, TC Wang
BMC Oral Health, 2019;19(1):10. 2019
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PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
Authors: C Lv, S Fu, Q Dong, Z Yu, G Zhang, C Kong, C Fu, Y Zeng
J. Exp. Clin. Cancer Res., 2019;38(1):24. 2019
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Epithelial?mesenchymal transition induced by bone morphogenetic protein 9 hinders cisplatin efficacy in ovarian cancer cells
Authors: Y Wang, B Yang, J Zhao, X Yu, X Liu, L Zhang, Y Zhang, X Li, Z Zhai
Mol Med Rep, 2019;0(0):. 2019
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Promotion of homology-directed DNA repair by polyamines
Authors: CY Lee, GC Su, WY Huang, MY Ko, HY Yeh, GD Chang, SJ Lin, P Chi
Nat Commun, 2019;10(1):65. 2019
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A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells
Authors: J Jiang, N Mao, H Hu, J Tang, D Han, S Liu, Q Wu, Y Liu, C Peng, J Lai, C Yang
Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):. 2019
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miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC? and ZEB1 inhibition
Authors: R El Bezawy, S Tinelli, M Tortoreto, V Doldi, V Zuco, M Folini, C Stucchi, T Rancati, R Valdagni, P Gandellini, N Zaffaroni
J. Exp. Clin. Cancer Res., 2019;38(1):51. 2019
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Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
Authors: P Nagarajan, PA Agudelo Ga, CC Iyer, LV Popova, WD Arnold, MR Parthun
Aging Cell, 2019;0(0):e12992. 2019
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Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
Authors: M Hong, J Li, S Li, M M Almutair
Cells, 2019;8(11):. 2019
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E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
Sci Rep, 2019;9(1):19035. 2019
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ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
Authors: SH Park, N Kang, E Song, M Wie, EA Lee, S Hwang, D Lee, JS Ra, IB Park, J Park, S Kang, JH Park, S Hohng, KY Lee, K Myung
Nat Commun, 2019;10(1):5718. 2019
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IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
Authors: J Panneersel, A Srivastava, M Mehta, A Chen, YD Zhao, A Munshi, R Ramesh
Cancers (Basel), 2019;11(12):. 2019
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Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
Nat Commun, 2019;10(1):5349. 2019
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Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
Authors: G Urrutia, A Salmonson, JA Toro-Zapat, TM de Assunca, A Mathison, N Dusetti, J Iovanna, R Urrutia, G Lomberk
Mol. Cancer Res., 2019;0(0):. 2019
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HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
Authors: D Andrade, M Mehta, J Griffith, S Oh, J Corbin, A Babu, S De, A Chen, YD Zhao, S Husain, S Roy, L Xu, J Aube, R Janknecht, M Gorospe, T Herman, R Ramesh, A Munshi
Cancers (Basel), 2019;11(12):. 2019
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Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
Authors: S Zhang, J Zhang, W Cheng, H Chen, A Wang, Y Liu, H Hou, Q Hu
Chemosphere, 2019;244(0):125482. 2019
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Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
Authors: Y Yu, W Jia, Y Lyu, D Su, M Bai, J Shen, J Qiao, T Han, W Liu, J Chen, W Chen, D Ye, X Guo, S Zhu, J Xi, R Zhu, X Wan, S Gao, J Zhu, J Kang
Cell Discov, 2019;5(0):47. 2019
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Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
Authors: JF Putri, P Bhargava, JK Dhanjal, T Yaguchi, D Sundar, SC Kaul, R Wadhwa
J. Exp. Clin. Cancer Res., 2019;38(1):499. 2019
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Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response
Authors: J Dziegielew, MA Bo?kowska, EA Poniecka, J Heo, K Du, RB Crittenden, TP Bender, DL Brautigan, JM Larner
DNA Repair (Amst.), 2019;85(0):102737. 2019
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Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
Authors: S Giovannini, MC Weller, S Repmann, H Moch, J Jiricny
Nucleic Acids Res., 2019;0(0):. 2019
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APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
Authors: CD Stefanski, K Keffler, S McClintock, L Milac, JR Prosperi
Neoplasia, 2019;21(12):1143-1150. 2019
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Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
Authors: DS Metselaar, MH Meel, B Benedict, P Waranecki, J Koster, GJL Kaspers, E Hulleman
EBioMedicine, 2019;0(0):. 2019
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Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma
Authors: AM Robinson, R Rathore, NJ Redlich, DR Adkins, T VanArsdale, BA Van Tine, LS Michel
Cell Death Dis, 2019;10(11):867. 2019
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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts
Authors: EY Chang, S Tsai, MJ Aristizaba, JP Wells, Y Coulombe, FF Busatto, YA Chan, A Kumar, Y Dan Zhu, AY Wang, LA Fournier, P Hieter, MS Kobor, JY Masson, PC Stirling
Nat Commun, 2019;10(1):4265. 2019
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BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
Authors: TY Lin, HH Chan, SH Chen, S Sarvagalla, PS Chen, MS Coumar, SM Cheng, YC Chang, CH Lin, E Leung, CHA Cheung
Autophagy, 2019;0(0):1-18. 2019
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Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
Authors: AL Perl, CM O'Connor, P Fa, F Mayca Pozo, J Zhang, Y Zhang, G Narla
J. Biol. Chem., 2019;0(0):. 2019
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Male mice, caged in the International Space Station for 35 days, sire healthy offspring
Authors: T Matsumura, T Noda, M Muratani, R Okada, M Yamane, A Isotani, T Kudo, S Takahashi, M Ikawa
Sci Rep, 2019;9(1):13733. 2019
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LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
Authors: JP Cebrià-Cos, L Pascual-Re, A Gonzalez-P, G Serra-Bard, J Querol, M Cosín, G Verde, RA Cigliano, W Sanseverin, S Segura-Bay, A Iturbide, D Andreu, P Nuciforo, C Bernado-Mo, V Rodilla, J Arribas, J Yelamos, AG de Herrero, TH Stracker, S Peiró
Oncogene, 2019;0(0):. 2019
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Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
Authors: Y Zhou, Y Xu, L Lu, J Ni, J Nie, J Cao, Y Jiao, Q Zhang
Theranostics, 2019;9(22):6665-6675. 2019
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Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells
Authors: A Kopacz, D Klóska, B Proniewski, D Cysewski, N Personnic, A Piechota-P, P Kaczara, A Zakrzewska, HJ Forman, J Dulak, A Józkowicz, A Grochot-Pr
Redox Biol, 2019;28(0):101304. 2019
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Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
Authors: S Lin, L Yu, X Song, J Bi, L Jiang, Y Wang, M He, Q Xiao, M Sun, OI Olopade, L Zhao, M Wei
Cell Death Dis, 2019;10(9):666. 2019
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Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
Authors: C Mani, S Jonnalagad, J Lingareddy, S Awasthi, WH Gmeiner, K Palle
Breast Cancer Res., 2019;21(1):104. 2019
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TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
Authors: J Chen, Z Wang, X Guo, F Li, Q Wei, X Chen, D Gong, Y Xu, W Chen, Y Liu, J Kang, Y Shi
Nat Commun, 2019;10(1):4273. 2019
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Precision Chemo-Radiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
Authors: DV Hingorani, MK Doan, MF Camargo, J Aguilera, SM Song, D Pizzo, DJ Scanderbeg, EEW Cohen, AM Lowy, SR Adams, SJ Advani
Mol. Cancer Ther., 2019;0(0):. 2019
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The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas
Authors: F Valenti, A Sacconi, F Ganci, G Grasso, S Strano, G Blandino, S Di Agostin
Cancers (Basel), 2019;11(9):. 2019
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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
Authors: A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, P Calsou, Y Pommier, G Favre, G Capranico, N Gromak, O Sordet
Cell Rep, 2019;28(12):3167-3181.e6. 2019
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Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia
Authors: SEF Kost, A Saleh, EM Mejia, M Mostafizar, EDJ Bouchard, V Banerji, AJ Marshall, SB Gibson, JB Johnston, S Katyal
Cancers (Basel), 2019;11(10):. 2019
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DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
Authors: X Xiao, J Liang, C Huang, K Li, F Xing, W Zhu, Z Lin, W Xu, G Wu, J Zhang, X Lin, Y Tan, J Cai, J Hu, X Chen, Y Huang, Z Qin, P Qiu, X Su, L Chen, Y Lin, H Zhang, G Yan
Nat Commun, 2018;9(1):4342. 2018
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
Authors: D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha
Nat Commun, 2018;9(1):5351. 2018
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Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.
Authors: Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, Qin Z
Blood, 2015;126(26):2821-31. 2015
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Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism.
Authors: Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J
Cancer Res, 2015;75(13):2663-73. 2015
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Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
J Pharmacol Exp Ther, 2014;348(3):360-71. 2014
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CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
Authors: Shibata E, Dar A, Dutta A
J Biol Chem, 2014;289(33):23056-64. 2014
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Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
Authors: Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan A, Boulton S, Ganesan S
J Biol Chem, 2013;288(45):32357-69. 2013
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DNA damage in normally and prematurely aged mice.
Authors: Maslov A, Ganapathi S, Westerhof M, Quispe-Tintaya W, White R, Van Houten B, Reiling E, Dolle M, van Steeg H, Hasty P, Hoeijmakers J, Vijg J
Aging Cell, 2013;12(3):467-77. 2013
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Low and high linear energy transfer radiation sensitization of HCC cells by metformin.
Authors: Kim E, Kim M, Cho C, Jung W, Jeong Y, Jeong J
J Radiat Res, 2013;55(3):432-42. 2013
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Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
Authors: Lee AY, Chiba T, Truong LN
J. Biol. Chem., 2012;287(4):2531-43. 2012
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BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress.
Authors: Liu Y, Vaithiyalingam S, Shi Q
Mol. Cell. Biol., 2011;31(21):4298-309. 2011
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Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
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HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.
Authors: Sadik H, Korangath P, Nguyen N, Gyorffy B, Kumar R, Hedayati M, Teo W, Park S, Panday H, Munoz T, Menyhart O, Shah N, Pandita R, Chang J, Deweese T, Chang H, Pandita T, Sukumar S
Cancer Res, 0;76(15):4443-56. 0
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Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Authors: Kim S, Jo S, Lee H, Kim T, Kim I, Yim J, Chung H
Anticancer Res, 0;33(12):5445-51. 0
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hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.
Authors: Paquet N, Adams M, Leong V, Ashton N, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess J, Bolderson E, O'Byrne K, Richard D
Nucleic Acids Res, 0;43(18):8817-29. 0
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Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
Authors: Liu C, Finke A, Diaz M, Rozhon W, Poppenberger B, Baubec T, Pecinka A
Plant Cell, 0;27(6):1788-800. 0
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Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.
Authors: Goldstein M, Kastan M
Cancer Res, 0;75(13):2699-707. 0
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Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Authors: Lu E, McLellan M, Ding L, Fulton R, Mardis E, Wilson R, Miller C, Westervelt P, DiPersio J, Link D, Walter M, Ley T, Graubert T
Blood, 0;124(26):3887-95. 0
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Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
Authors: Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B
J Biol Chem, 0;290(48):28675-82. 0
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LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.
Authors: Lehle S, Hildebrand D, Merz B, Malak P, Becker M, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O
Nucleic Acids Res, 0;42(6):e41. 0
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PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.
Authors: Yuan Z, Guo W, Yang J, Li L, Wang M, Lei Y, Wan Y, Zhao X, Luo N, Cheng P, Liu X, Nie C, Peng Y, Tong A, Wei Y
J Biol Chem, 0;290(24):14927-44. 0
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Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation.
Authors: Hedayati M, Haffner M, Coulter J, Raval R, Zhang Y, Zhou H, Mian O, Knight E, Razavi N, Dalrymple S, Isaacs J, Santos A, Hales R, Nelson W, Yegnasubramanian S, Deweese T
Clin Cancer Res, 0;22(13):3310-3319. 0
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A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
Authors: Wang Y, An R, Umanah G, Park H, Nambiar K, Eacker S, Kim B, Bao L, Harraz M, Chang C, Chen R, Wang J, Kam T, Jeong J, Xie Z, Neifert S, Qian J, Andrabi S, Blackshaw S, Zhu H, Song H, Ming G, Dawson V, Dawson T
Science, 0;354(6308):. 0
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Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.
Authors: Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston D
Genes Dev, 0;27(20):2274-91. 0
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Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.
Authors: Buckel L, Savariar E, Crisp J, Jones K, Hicks A, Scanderbeg D, Nguyen Q, Sicklick J, Lowy A, Tsien R, Advani S
Cancer Res, 0;75(7):1376-1387. 0
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The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition.
Authors: Chatterjee P, Choudhary G, Alswillah T, Xiong X, Heston W, Magi-Galluzzi C, Zhang J, Klein E, Almasan A
Mol Cancer Ther, 0;14(8):1896-906. 0
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Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
Mutagenesis, 0;28(6):653-60. 0
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Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks.
Authors: Matsuoka K, Iimori M, Niimi S, Tsukihara H, Watanabe S, Kiyonari S, Kiniwa M, Ando K, Tokunaga E, Saeki H, Oki E, Maehara Y, Kitao H
Mol Cancer Ther, 0;14(4):1004-13. 0
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Overexpression of HPV16 E6* Alters beta-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells.
Authors: Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves M, Duerksen-Hughes P
Cancer Genomics Proteomics, 0;13(4):259-73. 0
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Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-kappaB pathway.
Authors: Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra T, Mitra S, Sur S, Brasier A, Ba X, Boldogh I
J Immunol, 0;193(9):4643-53. 0
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The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.
Authors: Thangavel C, Boopathi E, Ciment S, Liu Y, O'Neill R, Sharma A, McMahon S, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker A, Knudsen K, Den R
Clin Cancer Res, 0;20(21):5468-5482. 0
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The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.
Authors: De K, Bolanos-Villegas P, Mitra S, Yang X, Homan G, Jauh G, Makaroff C
Plant Cell, 0;28(2):521-36. 0
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Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.
Authors: Wakasugi M, Sasaki T, Matsumoto M, Nagaoka M, Inoue K, Inobe M, Horibata K, Tanaka K, Matsunaga T
J Biol Chem, 0;289(41):28730-7. 0
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Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
Authors: Efimova E, Takahashi S, Shamsi N, Wu D, Labay E, Ulanovskaya O, Weichselbaum R, Kozmin S, Kron S
Mol Cancer Res, 0;14(2):173-84. 0
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ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
Authors: Yang H, Palmbos P, Wang L, Kim E, Ney G, Liu C, Prasad J, Misek D, Yu X, Ljungman M, Simeone D
J Biol Chem, 0;290(45):27146-57. 0
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ATM regulates NF-kappaB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
Authors: Fang L, Choudhary S, Zhao Y, Edeh C, Yang C, Boldogh I, Brasier A
Nucleic Acids Res, 0;42(13):8416-32. 0
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Human papillomavirus type 16 E6* induces oxidative stress and DNA damage.
Authors: Williams V, Filippova M, Filippov V, Payne K, Duerksen-Hughes P
J Virol, 0;88(12):6751-61. 0
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Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication.
Authors: Baer A, Austin D, Narayanan A, Popova T, Kainulainen M, Bailey C, Kashanchi F, Weber F, Kehn-Hall K
J Biol Chem, 0;287(10):7399-410. 0
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Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.
Authors: Maruyama C, Leigh N, Nelson J, McCall A, Mellas R, Lei P, Andreadis S, Baker O
J Dent Res, 0;94(11):1610-7. 0
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USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance.
Authors: Lee J, Chang N, Yoon Y, Yang H, Cho H, Kim E, Shin Y, Kang W, Oh Y, Mun G, Joo K, Nam D, Lee J
Neuro Oncol, 0;18(1):37-47. 0
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XPD-dependent activation of apoptosis in response to triplex-induced DNA damage.
Authors: Kaushik Tiwari M, Rogers F
Nucleic Acids Res, 0;41(19):8979-94. 0
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Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
Authors: Ming J, Sun B, Li Z, Lin L, Meng X, Han B, Wang R, Wu P, Li J, Cai J, Jiang C
Aging (Albany NY), 0;9(4):1233-1247. 0
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WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.
Authors: Abu-Odeh M, Salah Z, Herbel C, Hofmann T, Aqeilan R
Proc Natl Acad Sci U S A, 0;111(44):E4716-25. 0
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A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
Authors: Nicolae C, Aho E, Choe K, Constantin D, Hu H, Lee D, Myung K, Moldovan G
Nucleic Acids Res, 0;43(6):3143-53. 0
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PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.
Authors: Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger M
Nucleic Acids Res, 0;44(16):7630-45. 0
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Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
Authors: Matsuda S, Matsuda Y, Yanagisawa S, Ikura M, Ikura T, Matsuda T
Toxicol Sci, 0;151(2):224-35. 0
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Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study.
Authors: Duan H, Jia X, Zhai Q, Ma L, Wang S, Huang C, Wang H, Niu Y, Li X, Dai Y, Yu S, Gao W, Chen W, Zheng Y
Occup Environ Med, 0;73(2):83-90. 0
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miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells.
Authors: Huang S, Yang Z, Ma Y, Yang Y, Wang S
DNA Cell Biol, 0;36(4):303-310. 0
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Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis.
Authors: Di Simone N, De Spirito M, Di Nicuolo F, Tersigni C, Castellani R, Silano M, Maulucci G, Papi M, Marana R, Scambia G, Gasbarrini A
Biol Reprod, 0;89(4):88. 0
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hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Authors: Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J
Mol Cell Biol, 0;33(24):4960-70. 0
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Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Authors: Cleaver J, Brennan-Minnella A, Swanson R, Fong K, Chen J, Chou K, Chen Y, Revet I, Bezrookove V
Proc Natl Acad Sci U S A, 0;111(37):13487-92. 0
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A hormone-DNA repair circuit governs the response to genotoxic insult.
Authors: Goodwin J, Schiewer M, Dean J, Schrecengost R, de Leeuw R, Han S, Ma T, Den R, Dicker A, Feng F, Knudsen K
Cancer Discov, 0;3(11):1254-71. 0
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HT-COMET: a novel automated approach for high throughput assessment of human sperm chromatin quality.
Authors: Albert O, Reintsch W, Chan P, Robaire B
Hum Reprod, 0;31(5):938-46. 0
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2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF.
Authors: Shen W, Liang X, Sun H, Crooke S
Nucleic Acids Res, 0;43(9):4569-78. 0
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Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Authors: Kanai R, Rabkin S, Yip S, Sgubin D, Zaupa C, Hirose Y, Louis D, Wakimoto H, Martuza R
J Natl Cancer Inst, 0;104(1):42-55. 0
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Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-beta.
Authors: Hardee M, Marciscano A, Medina-Ramirez C, Zagzag D, Narayana A, Lonning S, Barcellos-Hoff M
Cancer Res, 0;72(16):4119-29. 0
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Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.
Authors: Kaushik Tiwari M, Adaku N, Peart N, Rogers F
Nucleic Acids Res, 0;44(16):7742-54. 0
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DNA Damage Response and DNA Repair in Skeletal Myocytes From a Mouse Model of Spinal Muscular Atrophy.
Authors: Fayzullina S, Martin L
J Neuropathol Exp Neurol, 0;75(9):889-902. 0
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Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells.
Authors: Jeon H, Yi J, Kim T, Oh Y, Lee H, Lee M, Bang J, Ko K, Ahn I, Ko K, Kim J, Park H, Lee J, Sohn S
Toxicol Res, 0;33(2):107-118. 0
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The Role of HMGB1 in Radioresistance of Bladder Cancer.
Authors: Shrivastava S, Mansure J, Almajed W, Cury F, Ferbeyre G, Popovic M, Seuntjens J, Kassouf W
Mol Cancer Ther, 0;15(3):471-9. 0
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Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells.
Authors: Li D, Cao W
Am J Physiol Gastrointest Liver Physiol, 0;306(10):G863-72. 0
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Doxorubicin and vincristine affect undifferentiated rat spermatogonia.
Authors: Beaud H, van Pelt A, Delbes G
Reproduction, 0;153(6):725-735. 0
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Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.
Authors: Martinez T, Phillips J, Karanja K, Polaczek P, Wang C, Li B, Campbell J, Dervan P
Nucleic Acids Res, 0;42(18):11546-59. 0
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Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.
Authors: Ishida N, Nakagawa T, Iemura S, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K
Mol Cell Biol, 0;37(4):. 0
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DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.
Authors: Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O
Nucleic Acids Res, 0;0(0):. 0
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MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Authors: Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman M, Greenberg R
Genes Dev, 0;29(18):1955-68. 0
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The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.
Authors: Donninger H, Clark J, Rinaldo F, Nelson N, Barnoud T, Schmidt M, Hobbing K, Vos M, Sils B, Clark G
Mol Cell Biol, 0;35(1):277-87. 0
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Thirdhand smoke causes DNA damage in human cells.
Authors: Hang B, Sarker A, Havel C, Saha S, Hazra T, Schick S, Jacob P, Rehan V, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel L
Mutagenesis, 0;28(4):381-91. 0
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Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.
Authors: Scanlon S, Glazer P
Mol Cancer Res, 0;12(7):1016-28. 0
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Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
Authors: Boichuk S, Lee D, Mehalek K, Makielski K, Wozniak A, Seneviratne D, Korzeniewski N, Cuevas R, Parry J, Brown M, Zewe J, Taguchi T, Kuan S, Schoffski P, Debiec-Rychter M, Duensing A
Cancer Res, 0;74(4):1200-13. 0
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NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
Authors: Li L, Reddy S, Lin Z, Liu S, Park H, Chun S, Bornmann W, Thibodeaux J, Yan J, Chakrabarti G, Xie X, Sumer B, Boothman D, Yordy J
Mol Cancer Ther, 0;15(7):1757-67. 0
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Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer.
Authors: Ziebarth A, Nowsheen S, Steg A, Shah M, Katre A, Dobbin Z, Han H, Lopez-Berestein G, Sood A, Conner M, Yang E, Landen C
Clin Cancer Res, 0;19(1):170-82. 0
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PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
Authors: Cheng X, Byrne M, Brown K, Konopleva M, Kornblau S, Bennett R, May W
Blood, 0;126(13):1585-94. 0
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Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Authors: Yang Y, Durando M, Smith-Roe S, Sproul C, Greenwalt A, Kaufmann W, Oh S, Hendrickson E, Vaziri C
Nucleic Acids Res, 0;41(4):2296-312. 0
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Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
Authors: McLaughlin D, Coey C, Yang W, Drohat A, Matunis M
J Biol Chem, 0;291(17):9014-24. 0
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Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
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Mol Cancer Ther, 0;13(6):1625-35. 0
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Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Authors: Proia D, Zhang C, Sequeira M, Jimenez J, He S, Spector N, Shapiro G, Tolaney S, Nagai M, Acquaviva J, Smith D, Sang J, Bates R, El-Hariry I
Clin Cancer Res, 0;20(2):413-24. 0
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A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
Authors: Feng Z, Zhang J
Nucleic Acids Res, 0;40(2):726-38. 0
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c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.
Authors: Luo H, Chen Z, Wang S, Zhang R, Qiu W, Zhao L, Peng C, Xu R, Chen W, Wang H, Chen Y, Yang J, Zhang X, Zhang S, Chen D, Wu W, Zhao C, Cheng G, Jiang T, Lu D, You Y, Liu N, Wang H
Brain, 0;138(0):3654-72. 0
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Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Authors: Liu G, Yang D, Rupaimoole R, Pecot C, Sun Y, Mangala L, Li X, Ji P, Cogdell D, Hu L, Wang Y, Rodriguez-Aguayo C, Lopez-Berestein G, Shmulevich I, De Cecco L, Chen K, Mezzanzanica D, Xue F, Sood A, Zhang W
J Natl Cancer Inst, 0;107(7):. 0
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Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
Authors: Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S
Mol Pharmacol, 0;82(6):1030-41. 0
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
Authors: Lancini C, van den Berk P, Vissers J, Gargiulo G, Song J, Hulsman D, Serresi M, Tanger E, Blom M, Vens C, van Lohuizen M, Jacobs H, Citterio E
J Exp Med, 0;211(9):1759-77. 0
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Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells.
Authors: Reelfs O, Macpherson P, Ren X, Xu Y, Karran P, Young A
Nucleic Acids Res, 0;39(22):9620-32. 0
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A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles.
Authors: Stoccoro A, Di Bucchianico S, Uboldi C, Coppede F, Ponti J, Placidi C, Blosi M, Ortelli S, Costa A, Migliore L
Mutagenesis, 0;31(5):511-29. 0
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Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.
Authors: Brachova P, Alvarez N, Van Voorhis B, Christenson L
Gynecol Oncol, 0;145(3):577-583. 0
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