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CometAssay Single Cell Gel Electrophoresis Assay

4250-050-K 274 Citations Datasheet / COA / SDS
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4250-050-K
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Citations (274)
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CometAssay Single Cell Gel Electrophoresis Assay Summary

Includes twenty-five specially treated CometSlides (2 Well) and sufficient reagents for 50 test samples.

Key Benefits

• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions

Product Specifications

  • Applicable for the analysis of either single- or double-strand DNA breaks
  • Study cellular responses to DNA damage
  • Screen for inhibitors of DNA repair
  • Test chemicals for toxicity
  • Screen for environmental mutagens

What is the CometAssay?

The Comet assay, or single cell gel electrophoresis assay, provides a simple and effective method for evaluating DNA damage in cells. The principle of the assay is based upon the ability of denatured, cleaved DNA fragments to migrate out of the nucleoid under the influence of an electric field, whereas undamaged DNA migrates slower and remains within the confines of the nucleoid when a current is applied. Evaluation of the DNA “comet” tail shape and migration pattern allows for assessment of DNA damage. The general Comet assay protocol includes first immobilizing cells in a bed of low melting point agarose, gently lysing the cells, treating cells with neutral or alkali solutions to unwind and denature the DNA as well as hydrolyze sites of damage. DNA is then subjected to electrophoresis and stained with a fluorescent DNA intercalating dye.

Kit Contents

• CometAssay Lysis Solution
• CometAssay LMAgarose
• CometSlides (2 Well, 25 Slides)
• 200 mM EDTA, pH 10

Specifications

Shipping Conditions
The product is shipped ambient or with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store products immediately at the temperature recommended on the product labels.
Species
N/A

Limitations

For research use only. Not for diagnostic use.

Product Datasheets

Product Datasheet
COA
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Citations for CometAssay Single Cell Gel Electrophoresis Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

274 Citations: Showing 1 - 10
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  1. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
    Authors: C Yang, C Tian, TE Hoffman, NK Jacobsen, SL Spencer
    Nature Communications, 2021;12(1):1747.  2021
  2. Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
    Authors: A Iftekhar, H Berger, N Bouznad, J Heuberger, F Boccellato, U Dobrindt, H Hermeking, M Sigal, TF Meyer
    Nature Communications, 2021;12(1):1003.  2021
  3. Exosome-derived microRNA-433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non-small cell lung cancer
    Authors: B Liu, R Zhang, Y Zhu, R Hao
    Oncology Letters, 2021;22(2):607.  2021
  4. PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA
    Authors: K Yano, RU Takahashi, B Shiotani, J Abe, T Shidooka, Y Sudo, Y Yamamoto, S Kan, H Sakagami, H Tahara
    The Journal of Biological Chemistry, 2021;297(1):100882.  2021
  5. Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair
    Authors: J Alonso-Mar, A Villanueva, JM Piulats, M Martínez-I, L Solé, J Martín-Lib, S Segura, RM Pujol, M Iglesias, A Bigas, F Gallardo, L Espinosa
    Oncogene, 2021;0(0):.  2021
  6. AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
    Authors: Y Jiang, Y Dong, Y Luo, S Jiang, FL Meng, M Tan, J Li, Y Zang
    Cell Reports, 2021;34(7):108713.  2021
  7. USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-&beta2 transcription
    Authors: X Jie, WP Fong, R Zhou, Y Zhao, Y Zhao, R Meng, S Zhang, X Dong, T Zhang, K Yang, G Wu, S Xu
    Cell Death and Differentiation, 2021;0(0):.  2021
  8. WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
    Authors: Q Zhou, X Chen, H He, S Peng, Y Zhang, J Zhang, L Cheng, S Liu, M Huang, R Xie, T Lin, J Huang
    Theranostics, 2021;11(10):4809-4824.  2021
  9. Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
    Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
    Nucleic Acids Res., 2020;0(0):.  2020
  10. Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
    Authors: S Duan, L Hu, B Dong, HL Jin, HB Wang
    Cell Rep, 2020;32(6):108019.  2020
  11. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
    Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
    EMBO Mol Med, 2020;12(6):e10622.  2020
  12. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
    Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
    Cell Rep, 2020;31(2):107518.  2020
  13. Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
    Authors: E Kong, HD Kim, J Kim
    Cell Death Differ., 2020;0(0):.  2020
  14. Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
    Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
    Front Pharmacol, 2020;11(0):263.  2020
  15. Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
    Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
    Sci Rep, 2020;10(1):4943.  2020
  16. Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
    Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
    Molecules, 2020;25(5):.  2020
  17. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
    Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
    Theranostics, 2020;10(7):3351-3365.  2020
  18. 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
    Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
    Mar Drugs, 2020;18(8):.  2020
  19. Germline biallelic MCM8 variants are associated with early-onset Lynch-like syndrome
    Authors: M Golubicki, L Bonjoch, JG Acuña-Ocho, M Díaz-Gay, J Muñoz, M Cuatrecasa, T Ocaña, S Iseas, G Mendez, D Cisterna, SA Schubert, M Nielsen, T van Wezel, Y Goldberg, E Pikarsky, J Robbio, E Roca, A Castells, F Balaguer, M Antelo, S Castellví-
    JCI Insight, 2020;0(0):.  2020
  20. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
    Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
    PLoS Genet., 2020;16(1):e1008558.  2020
  21. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
    Authors: S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.  2020
  22. An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
    Authors: L Gao, Y Zhang, L Zhao, W Niu, Y Tang, F Gao, P Cai, Q Yuan, X Wang, H Jiang, X Gao
    Sci Adv, 2020;6(29):eabb1421.  2020
  23. Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
    Authors: SE Noh, YS Juhnn
    Sci Rep, 2020;10(1):14455.  2020
  24. Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
    Authors: A Chakrabort, P Jenjaroenp, J Li, S El Hilali, A McCulley, B Haarer, EA Hoffman, A Belak, A Thorland, H Hehnly, C Schildkrau, CL Chen, VA Kuznetsov, W Feng
    Cell Rep, 2020;32(12):108179.  2020
  25. BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
    Authors: DS Edwards, R Maganti, JP Tanksley, J Luo, JJH Park, E Balkanska-, J Ling, SR Floyd
    Cell Rep, 2020;32(12):108166.  2020
  26. MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
    Authors: A Rodríguez, K Zhang, A Färkkilä, J Filiatraul, C Yang, M Velázquez, E Furutani, DC Goldman, B García de, G Garza-Mayé, K McQueen, LA Sambel, B Molina, L Torres, M González, E Vadillo, R Pelayo, WH Fleming, M Grompe, A Shimamura, S Hautaniemi, J Greenberge, S Frías, K Parmar, AD D'Andrea
    Cell Stem Cell, 2020;0(0):.  2020
  27. UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
    Authors: Y Huang, X Yang, Y Lu, Y Zhao, R Meng, S Zhang, X Dong, S Xu, G Wu
    Cell Death Differ., 2020;0(0):.  2020
  28. Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
    Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
    Science Advances, 2020;6(37):.  2020
  29. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage
    Authors: FC Lam, YW Kong, Q Huang, TL Vu Han, AD Maffa, EM Kasper, MB Yaffe
    Nat Commun, 2020;11(1):4083.  2020
  30. Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
    Authors: X Wang, X Chen, L Sun, W Qian
    PLoS Genet., 2019;15(4):e1008094.  2019
  31. Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
    Authors: M Cucè, ME Gallo Cant, MA Siciliano, C Riillo, D Caracciolo, F Scionti, N Staropoli, V Zuccalà, L Maltese, A Di Vito, K Grillone, V Barbieri, M Arbitrio, MT Di Martino, M Rossi, N Amodio, P Tagliaferr, P Tassone, C Botta
    J Hematol Oncol, 2019;12(1):32.  2019
  32. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019;10(4):274.  2019
  33. MiR-34s negatively regulate homologous recombination through targeting RAD51
    Authors: S Chen, R Liu, Q Wang, Z Qi, Y Hu, P Zhou, Z Wang
    Arch. Biochem. Biophys., 2019;666(0):73-82.  2019
  34. The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
    Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
    Int J Mol Sci, 2019;20(8):.  2019
  35. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
    Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
    Cell Stem Cell, 2019;0(0):.  2019
  36. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
    Authors: N Martinez-V, M Marigil, M García-Mou, M Gonzalez-H, JJ Aristu, LI Ramos-Garc, S Tejada, R Díez-Valle, A Patiño-Gar, OJ Becher, C Gomez-Manz, J Fueyo, MM Alonso
    Acta Neuropathol Commun, 2019;7(1):64.  2019
  37. PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
    Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
    Cell Rep, 2019;26(5):1333-1343.e7.  2019
  38. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
    Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
    Acta Neuropathol Commun, 2019;7(1):77.  2019
  39. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis
    Authors: HJ Wen, S Gao, Y Wang, M Ray, MA Magnuson, CVE Wright, MP Di Maglian, TL Frankel, HC Crawford
    Cell Mol Gastroenterol Hepatol, 2019;0(0):.  2019
  40. ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy
    Authors: MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, G Falkous, D Williams, P Cox, A Meynert, ES Raymond, H Morrison, S Brown, E Allan, I Aligianis, AP Jackson, BH Ramsahoye, A von Kriegs, RW Taylor, AJ Finch, DR FitzPatric
    PLoS Genet., 2019;15(3):e1007605.  2019
  41. PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells
    Authors: B Liu, L Lin, S Riazuddin, A Zubair, L Wang, LJ Di, R Li, TT Dong, CX Deng, WM Tong
    Int. J. Biochem. Cell Biol., 2019;109(0):40-58.  2019
  42. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
    Authors: A Chaiprason, Z Janjetovic, TK Kim, SG Jarrett, JA D'Orazio, MF Holick, EKY Tang, RC Tuckey, U Panich, W Li, AT Slominski
    Redox Biol, 2019;24(0):101206.  2019
  43. A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells
    Authors: J Jiang, N Mao, H Hu, J Tang, D Han, S Liu, Q Wu, Y Liu, C Peng, J Lai, C Yang
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.  2019
  44. Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
    Authors: A Wilson, V Menon, Z Khan, A Alam, L Litovchick, V Yakovlev
    Redox Biol, 2019;24(0):101169.  2019
  45. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
    Authors: G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka, AC Barros, M Woods, B Fu, F Yang, E Chen, M Ostermaier, T Stankovic, H Ponstingl, M Herzog, K Yusa, FM Martinez, ST Durant, Y Galanty, P Beli, DJ Adams, A Bradley, E Metzakopia, JV Forment, SP Jackson
    Nat Commun, 2019;10(1):87.  2019
  46. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
    Authors: D Zhang, X Hu, J Li, J Liu, L Baks-Te Bu, M Wiersma, NU Malik, DMS van Marion, M Tolouee, F Hoogstra-B, EAH Lanters, AM van Roon, AAF de Vries, DA Pijnappels, NMS de Groot, RH Henning, BJJM Brundel
    Nat Commun, 2019;10(1):1307.  2019
  47. Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
    Authors: E Lee, H Jeon, M Lee, J Ryu, C Kang, S Kim, J Jung, Y Kwon
    Sci Rep, 2019;9(1):2494.  2019
  48. Epithelial?mesenchymal transition induced by bone morphogenetic protein 9 hinders cisplatin efficacy in ovarian cancer cells
    Authors: Y Wang, B Yang, J Zhao, X Yu, X Liu, L Zhang, Y Zhang, X Li, Z Zhai
    Mol Med Rep, 2019;0(0):.  2019
  49. Promotion of homology-directed DNA repair by polyamines
    Authors: CY Lee, GC Su, WY Huang, MY Ko, HY Yeh, GD Chang, SJ Lin, P Chi
    Nat Commun, 2019;10(1):65.  2019
  50. Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
    Authors: P Nagarajan, PA Agudelo Ga, CC Iyer, LV Popova, WD Arnold, MR Parthun
    Aging Cell, 2019;0(0):e12992.  2019
  51. PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
    Authors: C Lv, S Fu, Q Dong, Z Yu, G Zhang, C Kong, C Fu, Y Zeng
    J. Exp. Clin. Cancer Res., 2019;38(1):24.  2019
  52. Molecular damage and responses of oral keratinocyte to hydrogen peroxide
    Authors: KY Lin, CH Chung, JS Ciou, PF Su, PW Wang, DB Shieh, TC Wang
    BMC Oral Health, 2019;19(1):10.  2019
  53. Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
    Authors: FJ Chou, Y Chen, D Chen, Y Niu, G Li, P Keng, S Yeh, C Chang
    EBioMedicine, 2019;0(0):.  2019
  54. Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
    Authors: T Lin, TC Lin, DJ McGrail, PK Bhupal, YH Ku, W Zhang, L Meng, SY Lin, G Peng, RYL Tsai
    Oncogene, 2019;0(0):.  2019
  55. Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica
    Authors: X Shao, B Zhao, B Wang, B Zhao, Y Zhu, Z Yuan, J Zhang
    Ecotoxicol. Environ. Saf., 2019;175(0):39-47.  2019
  56. Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes
    Authors: S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang
    Cell Rep, 2019;26(8):2194-2211.e6.  2019
  57. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
    Authors: J Wang, B Chan, M Tong, Y Paung, U Jo, D Martin, M Seeliger, J Haley, H Kim
    PLoS Genet., 2019;15(2):e1007983.  2019
  58. MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1
    Authors: Y Dai, X Lin, W Xu, X Lin, Q Huang, L Shi, Y Pan, Y Zhang, Y Zhu, C Li, L Liu, S Zhang
    Cell Death Dis, 2019;10(2):144.  2019
  59. Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
    Authors: Z Qi, Y Song, Q Ding, X Liao, R Li, G Liu, S Tsang, Z Cai
    Ecotoxicol. Environ. Saf., 2019;168(0):378-387.  2019
  60. miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC? and ZEB1 inhibition
    Authors: R El Bezawy, S Tinelli, M Tortoreto, V Doldi, V Zuco, M Folini, C Stucchi, T Rancati, R Valdagni, P Gandellini, N Zaffaroni
    J. Exp. Clin. Cancer Res., 2019;38(1):51.  2019
  61. A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
    Authors: M Wu, Y Wang, D Yang, Y Gong, F Rao, R Liu, Y Danna, J Li, J Fan, J Chen, W Zhang, Q Zhan
    EBioMedicine, 2019;0(0):.  2019
  62. miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis
    Authors: J Tao, M Fan, D Zhou, Y Hong, J Zhang, H Liu, S Sharma, G Wang, Q Dong
    Oxid Med Cell Longev, 2019;2019(0):2352079.  2019
  63. OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
    Authors: Z Wu, M Qiu, Y Guo, J Zhao, Z Liu, H Wang, M Meng, Z Yuan, Z Mi
    Cancer Cell Int., 2019;19(0):99.  2019
  64. Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
    Authors: S Giovannini, MC Weller, S Repmann, H Moch, J Jiricny
    Nucleic Acids Res., 2019;0(0):.  2019
  65. Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma
    Authors: AM Robinson, R Rathore, NJ Redlich, DR Adkins, T VanArsdale, BA Van Tine, LS Michel
    Cell Death Dis, 2019;10(11):867.  2019
  66. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
    Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
    Sci Rep, 2019;9(1):19035.  2019
  67. ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
    Authors: SH Park, N Kang, E Song, M Wie, EA Lee, S Hwang, D Lee, JS Ra, IB Park, J Park, S Kang, JH Park, S Hohng, KY Lee, K Myung
    Nat Commun, 2019;10(1):5718.  2019
  68. IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
    Authors: J Panneersel, A Srivastava, M Mehta, A Chen, YD Zhao, A Munshi, R Ramesh
    Cancers (Basel), 2019;11(12):.  2019
  69. Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
    Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
    Nat Commun, 2019;10(1):5349.  2019
  70. Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
    Authors: G Urrutia, A Salmonson, JA Toro-Zapat, TM de Assunca, A Mathison, N Dusetti, J Iovanna, R Urrutia, G Lomberk
    Mol. Cancer Res., 2019;0(0):.  2019
  71. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
    Authors: D Andrade, M Mehta, J Griffith, S Oh, J Corbin, A Babu, S De, A Chen, YD Zhao, S Husain, S Roy, L Xu, J Aube, R Janknecht, M Gorospe, T Herman, R Ramesh, A Munshi
    Cancers (Basel), 2019;11(12):.  2019
  72. Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
    Authors: S Zhang, J Zhang, W Cheng, H Chen, A Wang, Y Liu, H Hou, Q Hu
    Chemosphere, 2019;244(0):125482.  2019
  73. Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
    Authors: Y Yu, W Jia, Y Lyu, D Su, M Bai, J Shen, J Qiao, T Han, W Liu, J Chen, W Chen, D Ye, X Guo, S Zhu, J Xi, R Zhu, X Wan, S Gao, J Zhu, J Kang
    Cell Discov, 2019;5(0):47.  2019
  74. Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
    Authors: JF Putri, P Bhargava, JK Dhanjal, T Yaguchi, D Sundar, SC Kaul, R Wadhwa
    J. Exp. Clin. Cancer Res., 2019;38(1):499.  2019
  75. Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response
    Authors: J Dziegielew, MA Bo?kowska, EA Poniecka, J Heo, K Du, RB Crittenden, TP Bender, DL Brautigan, JM Larner
    DNA Repair (Amst.), 2019;85(0):102737.  2019
  76. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts
    Authors: EY Chang, S Tsai, MJ Aristizaba, JP Wells, Y Coulombe, FF Busatto, YA Chan, A Kumar, Y Dan Zhu, AY Wang, LA Fournier, P Hieter, MS Kobor, JY Masson, PC Stirling
    Nat Commun, 2019;10(1):4265.  2019
  77. APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
    Authors: CD Stefanski, K Keffler, S McClintock, L Milac, JR Prosperi
    Neoplasia, 2019;21(12):1143-1150.  2019
  78. Male mice, caged in the International Space Station for 35 days, sire healthy offspring
    Authors: T Matsumura, T Noda, M Muratani, R Okada, M Yamane, A Isotani, T Kudo, S Takahashi, M Ikawa
    Sci Rep, 2019;9(1):13733.  2019
  79. Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
    Authors: DS Metselaar, MH Meel, B Benedict, P Waranecki, J Koster, GJL Kaspers, E Hulleman
    EBioMedicine, 2019;0(0):.  2019
  80. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
    Authors: AL Perl, CM O'Connor, P Fa, F Mayca Pozo, J Zhang, Y Zhang, G Narla
    J. Biol. Chem., 2019;0(0):.  2019
  81. Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
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FAQs

  1. Are there other dyes beside SYBR Gold that can be used in the Comet Assay?

    • Yes, other dyes that can be substituted for SYBR Gold in staining solution for the Comet Assay. The important parameters to consider in choosing a DNA stain for the comet assay are similar fluorescence and decay rates for single-and  double-strand DNA. See Appendix C in the product insert for a table of DNA stains parameters. R&D Systems selected SYBR Gold dye due to the high background to noise ratio. It is the responsibility of the end-users to optimize the use of an alternative dye chosen for the Comet Assay.

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