CometAssay Single Cell Gel Electrophoresis Assay

Catalog # Availability Size / Price Qty
4250-050-K

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Citations (318)
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CometAssay Single Cell Gel Electrophoresis Assay Summary

Includes twenty-five specially treated CometSlides (2 Well) and sufficient reagents for 50 test samples.
 

Key Benefits

• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions

Product Specifications

  • Applicable for the analysis of either single- or double-strand DNA breaks
  • Study cellular responses to DNA damage
  • Screen for inhibitors of DNA repair
  • Test chemicals for toxicity
  • Screen for environmental mutagens

What is the CometAssay?

The Comet assay, or single cell gel electrophoresis assay, provides a simple and effective method for evaluating DNA damage in cells. The principle of the assay is based upon the ability of denatured, cleaved DNA fragments to migrate out of the nucleoid under the influence of an electric field, whereas undamaged DNA migrates slower and remains within the confines of the nucleoid when a current is applied. Evaluation of the DNA “comet” tail shape and migration pattern allows for assessment of DNA damage. The general Comet assay protocol includes first immobilizing cells in a bed of low melting point agarose, gently lysing the cells, treating cells with neutral or alkali solutions to unwind and denature the DNA as well as hydrolyze sites of damage. DNA is then subjected to electrophoresis and stained with a fluorescent DNA intercalating dye.

Kit Contents

• CometAssay Lysis Solution
• CometAssay LMAgarose
• CometSlides (2 Well, 25 Slides)
• 200 mM EDTA, pH 10

Specifications

Shipping Conditions
The product is shipped ambient or with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store products immediately at the temperature recommended on the product labels.
Species
N/A

Limitations

For research use only. Not for diagnostic use.

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Citations for CometAssay Single Cell Gel Electrophoresis Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

318 Citations: Showing 1 - 10
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  1. Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast
    Authors: S Zhao, Y Hong, YY Liang, XL Li, JC Shen, CC Sun, LL Chu, J Hu, H Wang, DX Xu, SC Zhang, DD Xu, T Xu, LL Zhao
    Redox Biology, 2022;55(0):102414.  2022
  2. Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer
    Authors: M Stanzione, J Zhong, E Wong, TJ LaSalle, JF Wise, A Simoneau, DT Myers, S Phat, M Sade-Feldm, MS Lawrence, MK Hadden, L Zou, AF Farago, NJ Dyson, BJ Drapkin
    Science Advances, 2022;8(19):eabn1229.  2022
  3. The Salutary Effects of Catalpol on Diesel Exhaust Particles-Induced Thrombogenic Changes and Cardiac Oxidative Stress, Inflammation and Apoptosis
    Authors: A Nemmar, S Beegam, NE Zaaba, S Alblooshi, S Alseiari, BH Ali
    Biomedicines, 2022;10(1):.  2022
  4. The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
    Authors: I Hirschler-, F Festa, S Huang, GL Moldovan, C Nicolae, A Dhoonmoon, L Bao, K Keefer, SJ Chen, HG Wang, JY Cheung, BA Miller
    Scientific Reports, 2022;12(1):6311.  2022
  5. SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia
    Authors: C Han, A Khodadadi-, AH Lorch, Q Jin, V Serafin, P Zhu, Y Politanska, L Sun, BT Gutierrez-, MV Pryzhkova, H Abdala-Val, ET Bartom, B Buldini, G Basso, SE Velu, K Sarma, BB Mattamana, BK Cho, RC Obeng, YA Goo, PW Jordan, A Tsirigos, Y Zhou, P Ntziachris
    Science Advances, 2022;8(3):eabj8357.  2022
  6. Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
    Authors: A Reilly, J Philip Cre, S Stewart, MC Stolla, Y Wang, J Du, R Wellington, S Busch, EH Estey, PS Becker, M Fang, SB Keel, JL Abkowitz, LA Soma, J Ma, Z Duan, S Doulatov
    Cell Stem Cell, 2022;0(0):.  2022
  7. Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
    Authors: TM Jones, CM Espitia, A Ooi, JE Bauman, JS Carew, ST Nawrocki
    Cell Death & Disease, 2022;13(4):350.  2022
  8. Assessment of the ameliorative effect of curcumin on pendimethalin-induced genetic and biochemical toxicity
    Authors: A Acar, D Singh, AK Srivastava
    Scientific Reports, 2022;12(1):2195.  2022
  9. Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations
    Authors: Y Zhang, J Wu, Y Fu, R Yu, H Su, Q Zheng, H Wu, S Zhou, K Wang, J Zhao, S Shen, G Xu, L Wang, C Yan, X Zou, Y Lv, S Zhang
    Oncogene, 2022;0(0):.  2022
  10. Cytotoxicity, crosslinking and biological activity of three mitomycins
    Authors: SY Cheng, L Delgado-Cr, CC Clement, O Zacarias, M Concheiro-, N Towler, T Snyder, M Zheng, N Almodovar, C Gonzalez, M Romaine, AM Sapse, E Champeil
    Bioorganic chemistry, 2022;123(0):105744.  2022
  11. RNase H2, mutated in Aicardi-Gouti�res syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
    Authors: A Cristini, M Tellier, F Constantin, C Accalai, LO Albulescu, R Heiringhof, N Bery, O Sordet, S Murphy, N Gromak
    Nature Communications, 2022;13(1):2961.  2022
  12. Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes
    Authors: AN Nail, LM McCaffrey, M Banerjee, AP Ferragut C, JC States
    Toxicology and Applied Pharmacology, 2022;446(0):116042.  2022
  13. Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming-A New Mechanism for SCLC Chemoresistance Boosted by Nicotine
    Authors: Y Wang, T Bian, L Song, Y Jiang, Z Huo, RG Salloum, GW Warren, FJ Kaye, N Fujioka, L Jin, C Xing
    Cancers, 2022;14(9):.  2022
  14. Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR
    Authors: AA Chughtai, J Pannhausen, P Dinger, J Wirtz, R Knüchel, NT Gaisa, MJ Eble, M Rose
    Biomedicines, 2022;10(6):.  2022
  15. Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response
    Authors: Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DW Li
    Cells, 2022;11(9):.  2022
  16. Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIalpha intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells
    Authors: VA Hernandez, J Carvajal-M, X Wang, M Pietrzak, JC Yalowich, TS Elton
    PLoS ONE, 2022;17(5):e0265794.  2022
  17. Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair
    Authors: J Alonso-Mar, A Villanueva, JM Piulats, M Martínez-I, L Solé, J Martín-Lib, S Segura, RM Pujol, M Iglesias, A Bigas, F Gallardo, L Espinosa
    Oncogene, 2021;0(0):.  2021
  18. USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-&beta2 transcription
    Authors: X Jie, WP Fong, R Zhou, Y Zhao, Y Zhao, R Meng, S Zhang, X Dong, T Zhang, K Yang, G Wu, S Xu
    Cell Death and Differentiation, 2021;0(0):.  2021
  19. WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
    Authors: Q Zhou, X Chen, H He, S Peng, Y Zhang, J Zhang, L Cheng, S Liu, M Huang, R Xie, T Lin, J Huang
    Theranostics, 2021;11(10):4809-4824.  2021
  20. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
    Authors: C Yang, C Tian, TE Hoffman, NK Jacobsen, SL Spencer
    Nature Communications, 2021;12(1):1747.  2021
  21. PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA
    Authors: K Yano, RU Takahashi, B Shiotani, J Abe, T Shidooka, Y Sudo, Y Yamamoto, S Kan, H Sakagami, H Tahara
    The Journal of Biological Chemistry, 2021;297(1):100882.  2021
  22. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
    Authors: Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier
    Nature Communications, 2021;12(1):5010.  2021
  23. Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling
    Authors: S Pal, BR Nixon, MS Glennon, P Shridhar, SL Satterfiel, YR Su, JR Becker
    Journal of the American Heart Association, 2021;10(15):e021768.  2021
  24. Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia
    Authors: J Bloehdorn, A Braun, A Taylor-Wei, BMC Jebaraj, S Robrecht, J Krzykalla, H Pan, A Giza, G Akylzhanov, K Holzmann, A Scheffold, HE Johnston, RF Yeh, T Klymenko, E Tausch, B Eichhorst, L Bullinger, K Fischer, M Weisser, T Robak, C Schneider, J Gribben, LN Dahal, MJ Carter, O Elemento, DA Landau, DS Neuberg, MS Cragg, A Benner, M Hallek, CJ Wu, H Döhner, S Stilgenbau, D Mertens
    Nature Communications, 2021;12(1):5395.  2021
  25. The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
    Authors: F Napoletano, G Ferrari Br, IAP Voto, A Santin, L Celora, E Campaner, C Dezi, A Bertossi, E Valentino, M Santorsola, A Rustighi, V Fajner, E Maspero, F Ansaloni, V Cancila, CF Valenti, M Santo, OB Artimagnel, S Finaurini, U Gioia, S Polo, R Sanges, C Tripodo, A Mallamaci, S Gustincich, F d'Adda di, F Mantovani, V Specchia, G Del Sal
    Cell Reports, 2021;36(11):109694.  2021
  26. Exosome-derived microRNA-433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non-small cell lung cancer
    Authors: B Liu, R Zhang, Y Zhu, R Hao
    Oncology Letters, 2021;22(2):607.  2021
  27. Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench
    Authors: Y Yang, Y Chong, M Chen, W Dai, X Zhou, Y Ji, G Qiu, X Du
    Journal of Translational Medicine, 2021;19(1):170.  2021
  28. VDAC1 oligomerization may enhance DDP-induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage
    Authors: X Zhu, L Luo, Y Xiong, N Jiang, Y Wang, Y Lv, Y Xie
    FEBS Open Bio, 2021;0(0):.  2021
  29. Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling
    Authors: S Hu, S Ren, Y Cai, J Liu, Y Han, Y Zhao, J Yang, X Zhou, X Wang
    Cell Death and Differentiation, 2021;0(0):.  2021
  30. Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage
    Authors: P Carotenuto, F Amato, A Lampis, C Rae, S Hedayat, MC Previdi, D Zito, M Raj, V Guzzardo, F Sclafani, A Lanese, C Parisi, C Vicentini, I Said-Hunti, JC Hahne, A Hallsworth, V Kirkin, K Young, R Begum, A Wotherspoo, K Kouvelakis, SX Azevedo, V Michalarea, R Upstill-Go, S Rao, D Watkins, N Starling, A Sadanandam, DK Chang, AV Biankin, NB Jamieson, A Scarpa, D Cunningham, I Chau, P Workman, M Fassan, N Valeri, C Braconi
    Nature Communications, 2021;12(1):6738.  2021
  31. Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
    Authors: A Iftekhar, H Berger, N Bouznad, J Heuberger, F Boccellato, U Dobrindt, H Hermeking, M Sigal, TF Meyer
    Nature Communications, 2021;12(1):1003.  2021
  32. AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
    Authors: Y Jiang, Y Dong, Y Luo, S Jiang, FL Meng, M Tan, J Li, Y Zang
    Cell Reports, 2021;34(7):108713.  2021
  33. Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
    Authors: JH Park, SJ Ryu, BJ Kim, HJ Cho, CH Park, HJC Choi, EJ Jang, EJ Yang, JA Hwang, SH Woo, JH Lee, JH Park, KM Choi, YY Kwon, CK Lee, JT Park, SC Cho, YI Lee, SB Lee, JA Han, KA Cho, MS Kim, D Hwang, YS Lee, SC Park
    Experimental & Molecular Medicine, 2021;53(6):1092-1108.  2021
  34. Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells
    Authors: W Zhang, J Yang, Y Chen, R Xue, Z Mao, W Lu, Y Jiang
    Aging Cell, 2021;0(0):e13307.  2021
  35. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
    Authors: MM Lou, XQ Tang, GM Wang, J He, F Luo, MF Guan, F Wang, H Zou, JY Wang, Q Zhang, MJ Xu, QL Shi, LB Shen, GM Ma, Y Wu, YY Zhang, AB Liang, TH Wang, LL Xiong, J Wang, J Xu, WY Wang
    Nature Communications, 2021;12(1):4075.  2021
  36. Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis
    Authors: EB Zhang, X Zhang, K Wang, F Zhang, TW Chen, N Ma, QZ Ni, YK Wang, QW Zheng, HJ Cao, J Xia, B Zhu, S Xu, X Ding, X Wang, Z Li, S Cheng, D Xie, JJ Li
    Oncogene, 2021;0(0):.  2021
  37. 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
    Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
    Mar Drugs, 2020;18(8):.  2020
  38. Germline biallelic MCM8 variants are associated with early-onset Lynch-like syndrome
    Authors: M Golubicki, L Bonjoch, JG Acuña-Ocho, M Díaz-Gay, J Muñoz, M Cuatrecasa, T Ocaña, S Iseas, G Mendez, D Cisterna, SA Schubert, M Nielsen, T van Wezel, Y Goldberg, E Pikarsky, J Robbio, E Roca, A Castells, F Balaguer, M Antelo, S Castellví-
    JCI Insight, 2020;0(0):.  2020
  39. BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
    Authors: DS Edwards, R Maganti, JP Tanksley, J Luo, JJH Park, E Balkanska-, J Ling, SR Floyd
    Cell Rep, 2020;32(12):108166.  2020
  40. Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
    Authors: A Chakrabort, P Jenjaroenp, J Li, S El Hilali, A McCulley, B Haarer, EA Hoffman, A Belak, A Thorland, H Hehnly, C Schildkrau, CL Chen, VA Kuznetsov, W Feng
    Cell Rep, 2020;32(12):108179.  2020
  41. Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
    Authors: SE Noh, YS Juhnn
    Sci Rep, 2020;10(1):14455.  2020
  42. An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
    Authors: L Gao, Y Zhang, L Zhao, W Niu, Y Tang, F Gao, P Cai, Q Yuan, X Wang, H Jiang, X Gao
    Sci Adv, 2020;6(29):eabb1421.  2020
  43. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage
    Authors: FC Lam, YW Kong, Q Huang, TL Vu Han, AD Maffa, EM Kasper, MB Yaffe
    Nat Commun, 2020;11(1):4083.  2020
  44. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
    Authors: S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.  2020
  45. Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
    Authors: S Duan, L Hu, B Dong, HL Jin, HB Wang
    Cell Rep, 2020;32(6):108019.  2020
  46. Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
    Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
    Sci Rep, 2020;10(1):4943.  2020
  47. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
    Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
    Theranostics, 2020;10(7):3351-3365.  2020
  48. Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
    Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
    Molecules, 2020;25(5):.  2020
  49. Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
    Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
    Science Advances, 2020;6(37):.  2020
  50. Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
    Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
    Front Pharmacol, 2020;11(0):263.  2020
  51. Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
    Authors: E Kong, HD Kim, J Kim
    Cell Death Differ., 2020;0(0):.  2020
  52. Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
    Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
    Cell Rep, 2020;31(2):107518.  2020
  53. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
    Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
    EMBO Mol Med, 2020;12(6):e10622.  2020
  54. Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
    Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
    Nucleic Acids Res., 2020;0(0):.  2020
  55. Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
    Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
    PLoS Genet., 2020;16(1):e1008558.  2020
  56. UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
    Authors: Y Huang, X Yang, Y Lu, Y Zhao, R Meng, S Zhang, X Dong, S Xu, G Wu
    Cell Death Differ., 2020;0(0):.  2020
  57. MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
    Authors: A Rodríguez, K Zhang, A Färkkilä, J Filiatraul, C Yang, M Velázquez, E Furutani, DC Goldman, B García de, G Garza-Mayé, K McQueen, LA Sambel, B Molina, L Torres, M González, E Vadillo, R Pelayo, WH Fleming, M Grompe, A Shimamura, S Hautaniemi, J Greenberge, S Frías, K Parmar, AD D'Andrea
    Cell Stem Cell, 2020;0(0):.  2020
  58. An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
    Authors: L Gao, Y Zhang, L Zhao, W Niu, Y Tang, F Gao, P Cai, Q Yuan, X Wang, H Jiang, X Gao
    Sci Adv, 2020;6(29):eabb1421.  2020
  59. Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells
    Authors: I Martínez-V, M Abrisqueta, C Herraiz, J Sirés-Camp, M Castejón-G, DC Bennett, C Olivares, JC García-Bor, C Jiménez-Ce
    Cancers (Basel), 2020;12(10):.  2020
  60. Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
    Authors: C Zhu, A Rogers, K Asleh, J Won, D Gao, S Leung, S Li, KR Vij, J Zhu, JM Held, Z You, TO Nielsen, J Shao
    Cell Rep, 2020;31(10):107745.  2020
  61. Inhibition of HIF-1alpha by Atorvastatin During 131I-RTX Therapy in Burkitt's Lymphoma Model
    Authors: EH Kim, HY Ko, AR Yu, H Kim, J Zaheer, HJ Kang, YC Lim, KD Cho, HY Joo, MK Kang, JJ Lee, SS Lee, HJ Kang, SM Lim, JS Kim
    Cancers (Basel), 2020;12(5):.  2020
  62. Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer
    Authors: DH Ha, A Min, S Kim, H Jang, SH Kim, HJ Kim, HS Ryu, JL Ku, KH Lee, SA Im
    Sci Rep, 2020;10(1):9930.  2020
  63. Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function
    Authors: Q Lin, L Wu, Z Ma, FA Chowdhury, HH Mazumder, W Du
    JCI Insight, 2020;5(10):.  2020
  64. Antiplasmodial and Genotoxic Study of Selected Ghanaian Medicinal Plants
    Authors: S Adukpo, D Elewosi, RH Asmah, AK Nyarko, PK Ekpe, DA Edoh, MF Ofori
    Evid Based Complement Alternat Med, 2020;2020(0):1582724.  2020
  65. Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer
    Authors: S Lim, Y Kim, SB Lee, HG Kang, DH Kim, JW Park, D Chung, H Kong, KH Yoo, Y Kim, W Han, KH Chun, JH Park
    Oncogenesis, 2020;9(10):91.  2020
  66. Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
    Authors: S Duan, L Hu, B Dong, HL Jin, HB Wang
    Cell Rep, 2020;32(6):108019.  2020
  67. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
    Authors: S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.  2020
  68. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage
    Authors: FC Lam, YW Kong, Q Huang, TL Vu Han, AD Maffa, EM Kasper, MB Yaffe
    Nat Commun, 2020;11(1):4083.  2020
  69. Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway
    Authors: Y Wang, S Chen, S Sun, G Liu, L Chen, Y Xia, J Cui, W Wang, X Jiang, L Zhang, Y Zhu, Y Zou, B Shi
    Front Pharmacol, 2020;11(0):1152.  2020
  70. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
    Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
    Acta Neuropathol Commun, 2019;7(1):77.  2019
  71. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
    Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
    Cell Stem Cell, 2019;0(0):.  2019
  72. Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
    Authors: X Wang, X Chen, L Sun, W Qian
    PLoS Genet., 2019;15(4):e1008094.  2019
  73. The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
    Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
    Int J Mol Sci, 2019;20(8):.  2019
  74. MiR-34s negatively regulate homologous recombination through targeting RAD51
    Authors: S Chen, R Liu, Q Wang, Z Qi, Y Hu, P Zhou, Z Wang
    Arch. Biochem. Biophys., 2019;666(0):73-82.  2019
  75. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019;10(4):274.  2019
  76. PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
    Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
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FAQs

  1. Are there other dyes beside SYBR Gold that can be used in the Comet Assay?

    • Yes, other dyes that can be substituted for SYBR Gold in staining solution for the Comet Assay. The important parameters to consider in choosing a DNA stain for the comet assay are similar fluorescence and decay rates for single-and  double-strand DNA. See Appendix C in the product insert for a table of DNA stains parameters. R&D Systems selected SYBR Gold dye due to the high background to noise ratio. It is the responsibility of the end-users to optimize the use of an alternative dye chosen for the Comet Assay.

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