Chemical Name: 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
Biological ActivityCPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 μM). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor.
Hermans et al.
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
Litschig et al.
A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates.
Annoura et al.
Citations for CPCCOEt
The citations listed below are publications that use Tocris products. Selected citations for CPCCOEt include:
28 Citations: Showing 1 - 10
DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai and Ford
Cell Rep 2018;25:3148
An excitatory GABA loop operating in vivo.
Authors: Astorga Et al.
Front Cell Neurosci 2015;9:275
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
Cell Rep 2015;35:4469
Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
Authors: Oh Et al.
Alcohol Clin Exp Res 2015;10:162
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One 2014;9:e106316
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Authors: Oh Et al.
Proc Natl Acad Sci U S A 2013;110:E305
Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.
Authors: Cozzoli Et al.
Mol Pain 2012;36:1623
Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors.
Authors: Tappe-Theodor Et al.
Proc Natl Acad Sci U S A 2011;7:38
Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
Authors: Zheng and Raman
J Neurosci 2011;31:10283
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
J Biol Chem 2010;68:1007
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
Authors: Jackson Et al.
PLoS One 2010;5:e11962
Mobilization of calcium from intracellular stores facilitates somatodendritic DA release.
Authors: Patel Et al.
J Neurosci 2009;29:6568
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Authors: Shin Et al.
J Biol Chem 2008;105:746
Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
Authors: Bloodgood and Sabatini
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Authors: Kirschstein Et al.
J Neurosci 2007;27:7696
Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Authors: Jan and Westbrook
J Neurosci 2007;27:132
Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
Authors: Duguid Et al.
J Neurosci 2007;27:12464
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
Authors: El-Kouhen Et al.
Br J Pharmacol 2006;149:761
Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal.
Authors: Hashimotodani Et al.
Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand.
Authors: Jong Et al.
Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
Authors: Calò Et al.
J Neurosci 2005;25:2245
Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons.
Authors: Wu Et al.
J Neurophysiol 2004;92:1216
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
Authors: Kawasaki Et al.
J Neurosci 2004;24:8310
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
Authors: Melis Et al.
J Neurosci 2004;24:10707
Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel.
Authors: Kitano Et al.
J Neurosci 2003;278:25101
Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.
Authors: Marino Et al.
Proc Natl Acad Sci U S A 2003;100:13668
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for CPCCOEt
Average Rating: 5 (Based on 1 Review)
Have you used CPCCOEt?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
We use bath application of CPCCOEt and MPEP to block mGluRs.