Cyclosporin H

Name: Cyclosporin H
Brand: Tocris Bioscience
SKU: 6982
Price: 385 USD
Availability: InStock

Tocris Bioscience | Catalog # 6982

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Citations (3)

Product Documents

Enhances lentiviral transduction

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Enhances lentiviral transduction

View all Viral Transduction Enhancers »

Product Description

Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E₂ (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).

Product Specifications for Cyclosporin H

Molecular Weight

1202.64

Formula

C₆₂H₁₁₁N₁₁O₁₂

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5-(N-Methyl-D-valine)cyclosporin A

CAS Number

83602-39-5

PubChem ID

6476564

InChI Key

PMATZTZNYRCHOR-JLPRAAIDSA-N

SMILES

[H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	120.26	100
	Ethanol	60.13	50

Preparing Stock Solutions for Cyclosporin H

The following data is based on the product molecular weight 1202.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.83 mL	4.16 mL	8.32 mL
5 mM	0.17 mL	0.83 mL	1.66 mL
10 mM	0.08 mL	0.42 mL	0.83 mL
50 mM	0.02 mL	0.08 mL	0.17 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Petrillo Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 2018 PMID: 30416070

Product Documents for Cyclosporin H

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Cyclosporin H

For research use only

Citations for Cyclosporin H

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