Chemical Name: 5-(N-Methyl-D-valine)cyclosporin A
Biological ActivityCyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells.
Petrillo et al.
Cell Stem Cell., 2018;23:820
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