Cytochrome P450 2C8 Antibody

Novus Biologicals | Catalog # NBP1-97759

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Cytochrome P450 2C8 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KNVALTRSYIREK corresponding to internal region according to NP_000761.3, NP_001185782.1, NP_001185783.1.

Specificity

This antibody is expected to recognize all reported isoforms (NP_000761.3; NP_001185782.1; NP_001185783.1). No cross-reactivity with other 2C proteins expected. Reported variants represent identical protein: NP_001185782.1, NP_001185784.1

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Cytochrome P450 2C8 Antibody

Western Blot: Cytochrome P450 2C8 Antibody [NBP1-97759]

Western Blot: Cytochrome P450 2C8 Antibody [NBP1-97759]

Western Blot: Cytochrome P450 2C8 Antibody [NBP1-97759] - (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Cytochrome P450 2C8 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 55 kDa band observed in human liver lysates (calculated MW of 55.8 kDa band according to NP_000761.3).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cytochrome P450 2C8

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Alternate Names

CPC8, CYPIIC8, cytochrome P450 2C8, Cytochrome P450 form 1, Cytochrome P450 IIC2, Cytochrome P450 MP-12, Cytochrome P450 MP-20, cytochrome P450, family 2, subfamily C, polypeptide 8, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8, EC 1.14.14.1, flavoprotein-linked monooxygenase, microsomal monooxygenase, MP-12/MP-20, P450 form 1, S-mephenytoin 4-hydroxylase, xenobiotic monooxygenase

Entrez Gene IDs

1558 (Human)

Gene Symbol

CYP2C8

UniProt

NP_000761.3 (Human)

Additional Cytochrome P450 2C8 Products

Product Documents for Cytochrome P450 2C8 Antibody

Certificate of Analysis

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Product Specific Notices for Cytochrome P450 2C8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Cytochrome P450 2C8 Antibody

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