DACH1 Antibody

Name: DACH1 Antibody
Brand: Novus Biologicals
SKU: NBP2-27192
Price: 339 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-27192

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Bovine, Canine, Chicken, Equine, Primate

Predicted:

Monkey (100%), Xenopus (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

Amino acids 474-501 of human Dach1 were used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 83% homologous in Zebrafish.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DACH1 Antibody

Western Blot: DACH1 Antibody [NBP2-27192]

Western Blot: DACH1 Antibody [NBP2-27192] - Analysis of DACH1 in human placenta lysate using NBP2-27192 at 5 ug/ml.

Immunohistochemistry-Paraffin: DACH1 Antibody [NBP2-27192]

Immunohistochemistry-Paraffin: DACH1 Antibody [NBP2-27192] - Analysis of Dach1 in formalin-fixed, paraffin-embedded human kidney tissue using an isotype control (top left) and this antibody (bottom left, right) at 5 ug/ml.

Applications for DACH1 Antibody

Application

Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Western Blot

5-7ug/ml~

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DACH1

Dachshund homolog 1 belongs to the DACH/Dachshund family. It is a transcription factor involved in the regulation of organogenesis. DACH1 plays a role in retinal and pituitary precursor cell proliferation. It is reported to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. DACH1 repressed TGF-beta induction of AP-1 and Smad signaling in gene reporter assays and repressed endogenous TGF-beta-responsive genes by microarray analyses. DACH1 participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4. Mouse DACH1 protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds.

Alternate Names

Dach1, DACHdachshund homolog 1, dachshund homolog (Drosophila), dachshund homolog 1 (Drosophila), FLJ10138

Gene Symbol

DACH1

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Product Documents for DACH1 Antibody

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Certificate of Analysis

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Product Specific Notices for DACH1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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