DC-SIGN/CD209 Antibody Pair [HRP]

Name: DC-SIGN/CD209 Antibody Pair [HRP]
Brand: Novus Biologicals
SKU: NBP2-79510
Price: 949 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-79510

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Product Specifications
Scientific Data
Kit Contents
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Assay Type

Sandwich ELISA

Assay Range

23.44-1500 pg/ml (example only; lot dependent)

Sensitivity

23.4375 pg/ml (example only; lot dependent)

Reactivity

Human

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Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human DC-SIGN/CD209.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for DC-SIGN/CD209 Antibody Pair [HRP]

Sandwich ELISA: DC-SIGN/CD209 Antibody Pair [HRP] [NBP2-79510] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for DC-SIGN/CD209 Antibody Pair [HRP]

Mouse Monoclonal Capture Antibody
Rabbit Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP2-89331)
Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: DC-SIGN/CD209

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Long Name

Dendritic Cell-specific ICAM-3-grabbing Non-integrin 1

Alternate Names

CD209, CLEC4L, DC-SIGN1, DCSIGN

Gene Symbol

CD209

Additional DC-SIGN/CD209 Products

Product Documents for DC-SIGN/CD209 Antibody Pair [HRP]

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Certificate of Analysis

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Product Specific Notices for DC-SIGN/CD209 Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.