DC-SIGN/CD209 Antibody

Name: DC-SIGN/CD209 Antibody
Brand: Novus Biologicals
SKU: NBP2-27408
Price: 149 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-27408

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Primate

Predicted:

Baboon (94%), Orangutan (100%), Rhesus Macaque (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

A portion of amino acids 320-370 from human DC-SIGN (CD209) was used as the immunogen for this antibody.

Reactivity Notes

Based upon immunogen sequence similarity, this antibody is predicted to react with: Chimpanzee (100%), Black crested gibbon (98%), Lar gibbon (98%), southern pig-tailed macaque (98%), African green monkey (94%), siamang (92%).

Marker

Dendritic Cell Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DC-SIGN/CD209 Antibody

Western Blot: DC-SIGN/CD209 Antibody [NBP2-27408]

Western Blot: DC-SIGN/CD209 Antibody [NBP2-27408] - Analysis of DC-SIGN (CD209) in human ThP-1 lysate in the A) absence and B) presence of immunizing peptide and C) mouse RAW lysate using DC-SIGN antibody at 3 ug/ml.

Applications for DC-SIGN/CD209 Antibody

Application

Recommended Usage

Western Blot

2-4ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DC-SIGN/CD209

DC-SIGN, also called CD209, is a C type lectin receptor and an acronym for Dendritic Cell-Specific intracellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin protein. DC-SIGN (CD209) is a 45kDa receptor which binds mannans and glycans on bacteria, viruses and fungi (1). Expressed on Dendritic Cells (DCs) and DC-like macrophages, DC-SIGN is an important cell interaction molecule mediating DC-T cell or DC-Neutrophil responses. DC-SIGN is especially important in DC Th1 interaction, regulating Th1 activity through it's role as a pathogen receptor (2-4). Interaction between DC-SIGN and TLR4 has been demonstrated for induction of inflammatory responses (5). As a CLR and innate immune receptor, DC-SIGN detection and quantitation with antibody probes are used as both a phenotype and indicator of a functional role in anti-microbial responses of DC's.

Long Name

Dendritic Cell-specific ICAM-3-grabbing Non-integrin 1

Alternate Names

CD209, CLEC4L, DC-SIGN1, DCSIGN

Gene Symbol

CD209

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Certificate of Analysis

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Product Specific Notices for DC-SIGN/CD209 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.