DMPK Antibody

Novus Biologicals | Catalog # NBP1-85010

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all DMPK Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVE

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (86%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DMPK Antibody

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010] - Analysis in human skeletal muscle and liver tissues using NBP1-85010 antibody. Corresponding DMPK RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010] - Staining of human tonsil shows very weak cytoplasmic positivity in non-germinal center cells.
Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010] - Staining of human prostate shows moderate cytoplasmic positivity in smooth muscle cells.
Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010]

Immunohistochemistry-Paraffin: DMPK Antibody [NBP1-85010] - Staining of human skeletal muscle shows strong cytoplasmic in myocytes.

Applications for DMPK Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DMPK

Dystrophia myotonica protein kinase is encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Long Name

Dystrophia Myotonica Protein Kinase

Alternate Names

DM1PK, DMK, MDPK, MT-PK

Gene Symbol

DMPK

Additional DMPK Products

Product Documents for DMPK Antibody

Certificate of Analysis

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Product Specific Notices for DMPK Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Intracellular Kinases

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Protocols

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