DNQX disodium salt

Tocris Bioscience | Catalog # 2312

Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Tocris Bioscience

Key Product Details

Description

Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
View all AMPA Receptor Antagonists »

Product Description

DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC50 = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.

Product Specifications for DNQX disodium salt

Molecular Weight

296.10

Formula

C8H2N4O6Na2

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6,7-Dinitroquinoxaline-2,3-dione disodium salt

CAS Number

1312992-24-7

PubChem ID

45073428

InChI Key

GPSBSOYURFUVKJ-UHFFFAOYSA-L

SMILES

[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.4 100

Preparing Stock Solutions for DNQX disodium salt

The following data is based on the product molecular weight 296.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.89 mL 33.77 mL
5 mM 0.68 mL 3.38 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 84 publications citing the usage of this product.

Product Documents for DNQX disodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DNQX disodium salt

For research use only

Citations for DNQX disodium salt

Customer Reviews for DNQX disodium salt (2)

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  • Works as expected.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Paraventricular nucleus of hypothalamus
    Verified Customer | Posted 06/01/2020
    DNQX (20 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
    DNQX disodium salt 2312
  • Highly recommend
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/14/2019
    We delivered this drug intracranially in combination with AP5 to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
    DNQX disodium salt 2312

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