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DNQX disodium salt

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DNQX disodium salt | CAS No. 1312992-24-7 | AMPA Receptor Antagonists
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Description: Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)

Chemical Name: 6,7-Dinitroquinoxaline-2,3-dione disodium salt

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products
Reviews (2)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Water-soluble form of DNQX (Cat. No. 0189). Selective non-NMDA receptor antagonist.

Technical Data

M.Wt:
296.1
Formula:
C8H2N4O6Na2
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1312992-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DNQX disodium salt

The citations listed below are publications that use Tocris products. Selected citations for DNQX disodium salt include:

8 Citations: Showing 1 - 8

  1. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
    Authors: Li Et al.
    Elife  2019;8
  2. Single-cell transcriptomic analysis of mouse neocortical development.
    Authors: Loo Et al.
    Nat Commun  2019;10:134
  3. Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus.
    Authors: Abrahao Et al.
    Neuropsychopharmacology  2017;42:1070
  4. Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
    Authors: Pan Et al.
    J Neurosci  2016;6:28137
  5. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  6. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Sci Rep  2015;112:1214
  7. Retinal input to efferent target amacrine cells in the avian retina.
    Authors: Lindstrom Et al.
    Proc Natl Acad Sci U S A  2010;27:103
  8. Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.
    Authors: Linnemann Et al.
    Vis Neurosci  2006;7:59

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Reviews for DNQX disodium salt

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Works as expected.
By Anonymous on 06/01/2020
Application: Species: Mouse

DNQX (20 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.

PMID: 32133707
Highly recommend
By Anonymous on 05/14/2019
Application: Species: Mouse

We delivered this drug intracranially in combination with AP5 to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.

PMID: 27378337
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