Endothelin-1 Quantikine ELISA Kit

Catalog # Availability Size / Price Qty
DET100
PDET100
SET100
Control Products Available
Multi-species Endothelin-1 ELISA Standard Curve
2 Images
Product Details
Procedure
Citations (58)
FAQs
Supplemental Products
Reviews (6)

Endothelin-1 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sensitivity
0.207 pg/mL
Assay Range
0.4 - 25 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine)
Specificity
Synthetic and natural Endothelin-1
Cross-reactivity
Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Endothelin-1 immunoassay is a 4.5 hour solid phase ELISA designed to measure ET-1 in cell culture supernates, serum, plasma, and urine. It contains synthetic ET-1 and antibodies raised against synthetic ET-1. This immunoassay has been shown to accurately quantitate synthetic and naturally occurring ET-1.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 3 7.34 14.7 3.05 7.43 14.4
Standard Deviation 0.12 0.17 0.28 0.231 0.438 0.759
CV% 4 2.3 1.9 7.6 5.9 5.3

Recovery

The recovery of Endothelin-1 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 99 88-108
Human EDTA Plasma (n=4) 93 87-102
Human Heparin Plasma (n=4) 93 85-106
Human Serum (n=4) 98 86-107
Mouse EDTA Plasma (n=4) 99 102-107
Mouse Serum (n=4) 94 86-104
Rat EDTA Plasma (n=4) 99 86-113
Rat Serum (n=4) 98 88-113
Urine (n=4) 91 85-109

Linearity

To assess the linearity of the assay, samples spiked with high concentrations of Endothelin-1 were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Multi-species Endothelin-1 ELISA Linearity

Data Examples

Multi-species Endothelin-1 ELISA Standard Curve

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Endothelin-1

Endothelin-1 (ET-1), a peptide of 21 amino acid (aa) residues, is a pleiotropic molecule best known for its action as a potent vasoconstrictor (1). Originally isolated from porcine aortic endothelial cells, ET-1 is one of a family of three proteins encoded by distinct genes that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3) (2, 3). ET-2 and ET-3 differ from ET-1 by 2 and 6 amino acids, respectively (1, 2). All members of the Endothelin family contain two essential disulfide bridges and six conserved aa residues at the C-terminus. Human ET-1 is initially synthesized as a pre-pro-polypeptide of 212 amino acids (2, 4). It is proteolytically cleaved by a signal peptidase to produce pro-ET-1 and further processed by a Furin-like protease to yield a 38 aa peptide termed Big ET-1 (5, 6). Big ET-1 is then cleaved by the membrane-bound metalloprotease Endothelin-converting enzyme (ECE-1), producing the potent 21 aa mature form ET-1 (aa 1-21) (7, 8). Alternatively, ET-1 may exist in an active 31 aa form (ET-1 (aa 1-31)) following cleavage of Big ET-1 by chymase (9-12). The vascular endothelium is an abundant source of ET-1 (3, 13). It may also be expressed by leukocytes, smooth muscle cells, mesangial cells, cardiac myocytes, and astrocytes (14, 15). ET-1 can be induced in endothelial cells by many factors including mechanical stimulation, various hormones, and pro-inflammatory cytokines (16). Production is inhibited by nitric oxide (NO), Prostacyclin, and atrial natriuretic peptide (ANP) (17-19). 

Two receptors for the Endothelin family have been cloned and designated ETA and ETB (20-23). ETA and ETB belong to the large family of heptahelical G protein-coupled receptors. The ETA receptor shows a higher affinity for ET-1 than for ET-2 and lowest affinity for ET-3, while the ETB receptor shows approximately equal affinity for each of the three Endothelins (21, 22, 24). ETA is primarily responsible for the vasoconstrictor effects of ET-1 and is expressed by blood vessel smooth muscle cells (25, 26). The ETB receptor is also present in smooth muscle and the endothelia of blood vessels, kidney, lung, and brain (27). ET-1 has the ability to activate an array of signaling cascades including classical phosphatidylinositol turnover pathways leading to downstream PKC activation and Ca2+ mobilization (28-32). Other potential signaling mediators activated or produced by ET-1 include PI 3-kinase/Akt, NO, FAK, and Rho GTPases (32-37). ET-1 signaling may also be mediated indirectly via transactivation of the EGF receptor leading to downstream signaling by Ras and MAP kinases (38, 39). Injection of a single dose of ET-1 produces an initial decrease in systemic blood pressure followed by a prolonged increase in blood pressure (16, 40, 41). Blockade of Endothelin receptors with a systemic injection of an ETA/ETB antagonist causes progressive vasodilation, and elevated levels of ET-1 are found in some forms of human hypertension (42, 43). ET-1 also stimulates cardiac contraction and the growth of cardiac myocytes, regulates the release of vasoactive substances, and stimulates smooth muscle cell mitogenesis (32, 44-46). It also acts as a pro-survival factor for endothelial cells and regulates secretion by hypothalamic and pituitary cells (47, 48). ET-1 may control inflammatory responses by promoting the adhesion and migration of neutrophils and stimulating the production of pro-inflammatory cytokines (49-53). It has also been implicated in cancer progression at several levels including regulating the proliferation and migration of tumor cells and acting as a pro-angiogenic factor (54, 55). In addition, ET-1 has putative roles in other pathologies including septic shock, atherosclerosis, heart failure, renal insufficiency, pulmonary hypertension, and cerebrovascular conditions associated with subarachnoid hemorrhage (15, 56-63).

Entrez Gene IDs:
1906 (Human); 13614 (Mouse); 24323 (Rat)
Alternate Names:
ARCND3; EDN1; endothelin 1; Endothelin-1; ET1; HDLCQ7; PPET1; preproendothelin-1; QME
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 150 µL Assay Diluent
  4.   Add 150 µL of Assay Diluent to each well.

  5. 75 µL Standard, Control, or Sample
  6.   Add 75 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 1 hour on a horizontal orbital microplate shaker.
  7.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.

  8. 200 µL Conjugate
  9.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 3 hours on the shaker.
  10.   Aspirate and wash 4 times.

  11. 200 µL Substrate Solution
  12.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.

  13. 50 µL Stop Solution
  14.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Endothelin-1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

58 Citations: Showing 1 - 10
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  1. LncRNA MALAT1 functions as a biomarker of no-reflow phenomenon in ST-segment elevation myocardial infarction patients receiving primary percutaneous coronary intervention
    Authors: X Yang, R Dai, Z Qin, R Cai, Y Xu, Q Su
    Scientific Reports, 2022;12(1):3294.
    Species: Human
    Sample Types: Plasma
  2. Acute effects of leg heat therapy on walking performance and cardiovascular and inflammatory responses to exercise in patients with peripheral artery disease
    Authors: JC Monroe, Q Song, MS Emery, DM Hirai, RL Motaganaha, BT Roseguini
    Physiological Reports, 2021;8(24):e14650.
    Species: Human
    Sample Types: Plasma
  3. Differences in Endothelial Activation and Dysfunction Induced by Antiphospholipid Antibodies Among Groups of Patients With Thrombotic, Refractory, and Non-refractory Antiphospholipid Syndrome
    Authors: M Velásquez, LF Peláez, M Rojas, R Narváez-Sá, JA Velásquez, C Escudero, S San Martín, ÁP Cadavid
    Frontiers in Physiology, 2021;12(0):764702.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling
    Authors: X Nie, C Shen, J Tan, X Yang, W Wang, Y Dai, H Sun, Z Wu, J Chen
    Biomolecules, 2021;11(12):.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Diagnostic prediction model in subjects with low-risk unstable angina pectoris/non-ST segment Elevation Myocardial Infarction
    Authors: I Dakota, M Munawar, R Pranata, WM Raffaello, R Sukmawan
    European review for medical and pharmacological sciences, 2021;25(16):5145-5152.
    Species: Human
    Sample Types: Plasma
  6. Sorafenib not only impairs endothelium-dependent relaxation but also promotes vasoconstriction through the upregulation of vasoconstrictive endothelin type B receptors
    Authors: Q Yu, K Li, A Zhao, M Wei, Z Huang, Y Zhang, Y Chen, L Ting, W Chuan, L Xu, Y Zhang, C Xu, F Liu
    Toxicology and Applied Pharmacology, 2021;414(0):115420.
    Species: Rat
    Sample Types: Plasma
  7. Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53
    Authors: S Ríos-Arrab, JD Puentes-Pa, S Moreno-San, Á Szuba, J Casado, M García-Cos, J Escudero-F, M Verbeni, C Cano, C González-P, A Martín-Lag, Á Carazo, J León
    Journal of personalized medicine, 2021;11(6):.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes
    Authors: E Nassar, N Hassan, EA El-Ghonaim, H Hassan, MS Abdullah, TV Rottke, L Kiesel, B Greve, SA Ibrahim, M Götte
    Cancers, 2021;13(10):.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Prolyl Endopeptidase contributes to early neutrophilic inflammation in acute cardiac transplant rejection
    Authors: GA Payne, NS Sharma, CV Lal, C Song, L Guo, C Margaroli, L Viera, S Kumar, J Li, M Bosley, D Xing, X Xu, JM Wells, JF George, JA Tallaj, M Leesar, JE Blalock, A Gaggar
    JCI Insight, 2021;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  10. Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients
    Authors: Y Osawa, S Yoshio, Y Aoki, M Korenaga, M Imamura, T Oide, M Okawara, H Kawai, Y Tsutsui, Y Yoshida, S Yoshikawa, T Mori, T Yamazoe, T Kanto
    BMC gastroenterology, 2021;21(1):55.
    Species: Human
    Sample Types: Plasma
  11. Preoperative Serum GDF-15, Endothelin-1 Levels, and Intraoperative Factors as Short-Term Operative Risks for Patients Undergoing Cardiovascular Surgery
    Authors: T Kato, T Nakajima, T Fukuda, I Shibasaki, T Hasegawa, K Ogata, H Ogawa, S Hirota, H Ohashi, S Saito, Y Takei, M Tezuka, M Seki, T Kuwata, M Sakuma, S Abe, S Toyoda, T Inoue, H Fukuda
    Journal of Clinical Medicine, 2021;10(9):.
    Species: Human
    Sample Types: Serum
  12. Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
    Authors: HM Kang, M Hasanuzzam, SW Kim, HJ Koh, SC Lee
    PLoS ONE, 2021;16(6):e0252530.
    Species: Human
    Sample Types: Aqueous Humor
  13. Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers
    Authors: CVB Figueiredo, RP Santiago, CC da Guarda, RM Oliveira, LM Fiuza, SCMA Yahouédého, SP Carvalho, JSDS Neres, AMJ Oliveira, CA Fonseca, VML Nascimento, IM Lyra, MM Aleluia, MS Goncalves
    PLoS ONE, 2021;16(2):e0246067.
    Species: Human
    Sample Types: Serum
  14. Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model
    Authors: MR Kim, HJ Kim, SH Yu, BS Lee, SY Jeon, JJ Lee, YC Lee
    Evid Based Complement Alternat Med, 2020;2020(0):7941391.
    Species: Rat
    Sample Types: Serum
  15. Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy
    Authors: DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker
    PLoS ONE, 2020;15(4):e0232287.
    Species: Human
    Sample Types: Plasma
  16. Exercise-Induced Elevated BDNF Level Does Not Prevent Cognitive Impairment Due to Acute Exposure to Moderate Hypoxia in Well-Trained Athletes
    Authors: Z Piotrowicz, M Chalimoniu, K P?oszczyca, M Czuba, J Langfort
    Int J Mol Sci, 2020;21(15):.
    Species: Human
    Sample Types: Serum
  17. Acute Effects of Metformin and Vildagliptin after a Lipid-Rich Meal on Postprandial Microvascular Reactivity in Patients with Type 2 Diabetes and Obesity: A Randomized Trial
    Authors: A Schiappaca, PA Maranhão, MDGC Souza, DG Panazzolo, JF Nogueira N, E Bouskela, LG Kraemer-Ag
    J Clin Med, 2020;9(10):.
    Species: Human
    Sample Types: Plasma
  18. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
    Authors: RP Santiago, CVB Figueiredo, LM Fiuza, SCMA Yahouédého, RM Oliveira, MM Aleluia, SP Carvalho, CA Fonseca, VML Nascimento, LC Rocha, CC Guarda, MS Gonçalves
    Dis Markers, 2020;2020(0):8867986.
    Species: Human
    Sample Types: Serum
  19. Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension
    Authors: J Chen, J Argemi, G Odena, MJ Xu, Y Cai, V Massey, A Parrish, R Vadigepall, J Altamirano, J Cabezas, P Gines, J Caballeria, N Snider, P Sancho-Bru, S Akira, I Rusyn, B Gao, R Bataller
    Scientific Reports, 2020;10(1):15558.
    Species: Human
    Sample Types: Serum
  20. Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction
    Authors: V Selvaraju, P Ayine, M Fadamiro, JR Babu, M Brown, T Geetha
    Oxid Med Cell Longev, 2019;2019(0):9604740.
    Species: Human
    Sample Types: Urine
  21. Increased Levels of Endothelin-1 in Cerebrospinal Fluid Are a Marker of Poor Visual Recovery after Optic Neuritis in Multiple Sclerosis Patients
    Authors: M Castellazz, G Lamberti, MV Resi, E Baldi, LM Caniatti, G Galante, P Perri, M Pugliatti
    Dis. Markers, 2019;2019(0):9320791.
    Species: Human
    Sample Types: Serum
  22. Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients
    Authors: CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin
    J Clin Med, 2018;7(11):.
    Species: Human
    Sample Types: Plasma
  23. Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes
    Authors: F Mayyas, R Jaradat, KH Alzoubi
    Nutr Metab Cardiovasc Dis, 2018;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  24. Preeclamptic plasma stimulates the expression of miRNAs, leading to a decrease in endothelin-1 production in endothelial cells
    Authors: M Caldeira-D, MR Luizon, E Deffune, JE Tanus-Sant, PP Freire, RF Carvalho, H Bettiol, VC Cardoso, M Antonio Ba, RC Cavalli, VC Sandrim
    Pregnancy Hypertens, 2018;12(0):75-81.
    Species: Human
    Sample Types: Cell Culture Supernates
  25. A Pecan-Rich Diet Improves Cardiometabolic Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial
    Authors: DL McKay, M Eliasziw, CYO Chen, JB Blumberg
    Nutrients, 2018;10(3):.
    Species: Human
    Sample Types: Serum
  26. The Potential Therapeutic Role of Peroxisome ProliferatorActivated Receptors Agonist in Preeclamptic Pregnant Rats
    Authors: HIG Allam, AAA Masri
    J Coll Physicians Surg Pak, 2018;28(1):31-35.
    Species: Rat
    Sample Types: Plasma
  27. Trans-repression of NF?B pathway mediated by PPAR? improves vascular endothelium insulin resistance
    Authors: Y Kong, Y Gao, D Lan, Y Zhang, R Zhan, M Liu, Z Zhu, G Zeng, Q Huang
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Rat
    Sample Types: Serum
  28. Influence of bradykinin B2 receptor and dopamine D2 receptor on the oxidative stress, inflammatory response, and apoptotic process in human endothelial cells
    Authors: A Niewiarows, A Kozik, I Guevara-Lo
    PLoS ONE, 2018;13(11):e0206443.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction
    Authors: M Houde, A Schwertani, H Touil, L Desbiens, O Sarrhini, R Lecomte, M Lepage, H Gagnon, S Takai, G Pejler, D Jacques, F Gobeil, R Day, P D'Orléans-
    Front Pharmacol, 2018;9(0):868.
    Species: Mouse
    Sample Types: Tissue Homogenates
  30. Canagliflozin inhibits interleukin-1?-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms
    Authors: SJ Mancini, D Boyd, OJ Katwan, A Strembitsk, TA Almabrouk, S Kennedy, TM Palmer, IP Salt
    Sci Rep, 2018;8(1):5276.
    Species: Human
    Sample Types: Cell Culture Supernates
  31. Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling
    Authors: CD Ruediger, B John, S Kumar, HS Lim, G Rangnekar, KC Roberts-Th, GD Young, D Chase, P Sanders, SR Willoughby
    Indian Pacing Electrophysiol J, 2018;18(1):1-5.
    Species: Human
    Sample Types: Serum
  32. Tumor characterization by ultrasound-release of multiple protein and microRNA biomarkers, preclinical and clinical evidence
    Authors: AL D'Souza, JR Chevillet, P Ghanouni, X Yan, M Tewari, SS Gambhir
    PLoS ONE, 2018;13(3):e0194268.
    Species: Human
    Sample Types: Plasma
  33. Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ? a cross-sectional study
    Authors: YH Li, WH Sheu, WJ Lee, J- Wang, CP Fu, KW Liang, IT Lee
    Sci Rep, 2018;8(1):7378.
    Species: Human
    Sample Types: Serum
  34. The effect of low and high-intensity cycling in diesel exhaust on flow-mediated dilation, circulating NOx, endothelin-1 and blood pressure
    Authors: LV Giles, SJ Tebbutt, C Carlsten, MS Koehle
    PLoS ONE, 2018;13(2):e0192419.
    Species: Human
    Sample Types: Plasma
  35. Chronic ETAantagonist reverses hypertension and impairment of structure and function of peripheral small arteries in aortic stiffening
    Authors: X Guo, H Chen, L Han, S Haulon, GS Kassab
    Sci Rep, 2018;8(1):3076.
    Species: Rat
    Sample Types: Serum
  36. Adipose-Derived Stromal Vascular Fraction/Xenohybrid Bone Scaffold: An Alternative Source for Bone Regeneration
    Authors: I Roato, DC Belisario, M Compagno, L Verderio, A Sighinolfi, F Mussano, T Genova, F Veneziano, G Pertici, G Perale, R Ferracini
    Stem Cells Int, 2018;2018(0):4126379.
    Species: Human
    Sample Types: Cell Culture Supernates
  37. Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration
    Authors: N Chebib, F Archer, A Bobet-Erny, C Leroux, V Cottin
    Sci Rep, 2018;8(1):14698.
    Species: Human
    Sample Types: Serum
  38. Preliminary study of hypoxia-related cardiovascular mediator-markers in patients with end-stage renal disease with and without diabetes and the effects of haemodialysis
    Authors: A Treweeke, J Hall, S Lambie, SJ Leslie, IL Megson, SM MacRury
    PLoS ONE, 2017;12(5):e0178171.
    Species: Human
    Sample Types: Plasma
  39. HMGB1 contributes to glomerular endothelial cell injury in ANCA-associated vasculitis through enhancing endothelium-neutrophil interactions
    Authors: C Wang, DY Chang, M Chen, MH Zhao
    J. Cell. Mol. Med, 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  40. The endothelin B receptor plays a crucial role for the adhesion of neutrophils to the endothelium in sickle cell disease
    Authors: B Koehl, P Nivoit, W El Nemer, O Lenoir, P Hermand, C Pereira, V Brousse, L Guyonnet, G Ghinatti, M Benkerrou, Y Colin, C Le Van Kim, PL Tharaux
    Haematologica, 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  41. Peripheral venous congestion causes time- and dose-dependent release of endothelin-1 in humans
    Authors: J Lin, N Chudasama, Y Hayashi, C Hawk, SD Ramnauth, KY Wong, A Harxhi, D Onat, M Wakabayash, N Uriel, UP Jorde, TH LeJemtel, HN Sabbah, RT Demmer, PC Colombo
    Physiol Rep, 2017;5(6):.
    Species: Human
    Sample Types: Plasma
  42. Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma
    Authors: A Russignan, C Spina, N Tamassia, A Cassaro, A Rigo, A Bagnato, L Rosanò, A Bonalumi, M Gottardi, L Zanatta, A Giacomazzi, MT Scupoli, M Tinelli, U Salvadori, F Mosna, A Zamò, MA Cassatella, F Vinante, C Tecchio
    Br. J. Haematol., 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  43. Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment
    Authors: W Khalid, SS Varghese, M Sankari, ND Jayakumar
    J Clin Diagn Res, 2017;11(4):ZC78-ZC81.
    Species: Human
    Sample Types: Serum
  44. Cellular microbiology of Mycoplasma canis
    Authors: DL Michaels, JA Leibowitz, MT Azaiza, PK Shil, SM Shama, GF Kutish, SL Distelhors, MF Balish, MA May, DR Brown
    Infect Immun, 2016;0(0):.
    Species: Canine
    Sample Types: Cell Culture Supernates
  45. Habitual cocoa intake reduces arterial stiffness in postmenopausal women regardless of intake frequency: a randomized parallel-group study
    Authors: Koichi Nakazato
    Clin Interv Aging, 2016;11(0):1645-1652.
    Species: Human
    Sample Types: Plasma
  46. Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China
    Authors: Shaowei Wu
    Sci. Total Environ, 2016;560(0):141-9.
    Species: Human
    Sample Types: Plasma
  47. EDN1 Gene Variant is Associated with Neonatal Persistent Pulmonary Hypertension
    Sci Rep, 2016;6(0):29877.
    Species: Human
    Sample Types: Serum
  48. Effects of equivalent sympathetic activation during hypoglycemia on endothelial function and pro-atherothrombotic balance in healthy individuals and obese standard treated type 2 diabetes
    Authors: Stephen N Davis
    Metab. Clin. Exp., 2016;65(12):1695-1705.
    Species: Human
    Sample Types: Plasma
  49. Citreoviridin Enhances Atherogenesis in Hypercholesterolemic ApoE-Deficient Mice via Upregulating Inflammation and Endothelial Dysfunction.
    Authors: Hou H, Yuan N, Guo Q, Sun T, Li C, Liu J, Li Q, Jiang B
    PLoS ONE, 2015;10(5):e0125956.
    Species: Mouse
    Sample Types: Serum
  50. Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure.
    Authors: Wang J, Wang D, Wang H, Wang Z, Wen Y, Sun C, Zhao Y, Wu J, Liu P
    Lab Invest, 2014;94(7):740-51.
    Species: Rat
    Sample Types: Serum
  51. Endothelin A receptor antagonism enhances inhibitory effects of anti-ganglioside GD2 monoclonal antibody on invasiveness and viability of human osteosarcoma cells.
    Authors: Liu B, Wu Y, Zhou Y, Peng D
    PLoS ONE, 2014;9(4):e93576.
    Species: Human
    Sample Types: Cell Culture Supernates
  52. Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients.
    Authors: Pallis F, Conran N, Fertrin K, Olalla Saad S, Costa F, Franco-Penteado C
    Br J Haematol, 2014;164(2):286-95.
    Species: Human
    Sample Types: Plasma
  53. TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.
    Authors: Liu, Boyi, Escalera, Jasmine, Balakrishna, Shrilath, Fan, Lu, Caceres, Ana I, Robinson, Eve, Sui, Aiwei, McKay, M Craig, McAlexander, M Allen, Herrick, Christin, Jordt, Sven E
    FASEB J, 2013;27(9):3549-63.
    Species: Mouse
    Sample Types: Tissue Homogenates
  54. The mechanism through which octreotide inhibits hepatic stellate cell activity.
    Authors: Wang J, Wang L, Song G, Han B
    Mol Med Rep, 2013;7(5):1559-64.
    Species: Human
    Sample Types: Cell Culture Supernates
  55. Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice.
    Authors: Sang, Hui, Yuan, Na, Yao, Shutong, Li, Furong, Wang, Jiafu, Fang, Yongqi, Qin, Shucun
    Lipids Health Dis, 2012;11(0):166.
    Species: Mouse
    Sample Types: Serum
  56. Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP(3) pathway: implications for placental pathophysiology in preeclampsia.
    Authors: Jain A, Olovsson M, Burton GJ, Yung HW
    Am. J. Pathol., 2012;180(6):2309-20.
    Species: Human
    Sample Types: Cell Culture Supernates
  57. Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
    Authors: Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, ØIe E
    PLoS ONE, 2012;7(5):e36815.
    Species: Human
    Sample Types: Plasma
  58. The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial.
    Authors: Rafnsson A, Bohm F, Settergren M, Gonon A, Brismar K, Pernow J
    Diabetologia, 2011;55(3):600-7.
    Species: Human
    Sample Types: Plasma

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Average Rating: 4.8 (Based on 6 Reviews)

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Endothelin-1 Quantikine ELISA Kit
By Anonymous on 08/22/2019
Application: Sample Tested: EDTA Plasma

Endothelin-1 Quantikine ELISA Kit
By Anonymous on 12/17/2018
Application: Sample Tested: Urine

Endothelin-1 Quantikine ELISA Kit
By Anonymous on 10/11/2018
Application: Sample Tested: Serum and Plasma

Endothelin-1 Quantikine ELISA Kit
By Anonymous on 09/11/2018
Application: Sample Tested: Urine

Endothelin-1 Quantikine ELISA Kit
By Anonymous on 10/23/2017
Application: Sample Tested: Plasma

Plasma was used from male mice.


Endothelin-1 Quantikine ELISA Kit
By Anonymous on 08/02/2017
Application: Sample Tested: Serum and Plasma