FGF acidic/FGF1, also known as ECGF and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF1 can translocate to the cytosol and to the nucleus. Intracellular FGF1 functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.
FGF acidic/FGF1 Antibody (C16) - BSA Free
Novus Biologicals | Catalog # NBP3-41078
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Key Product Details
Species Reactivity
Human, Mouse, Rat, Porcine
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # C16
Format
BSA Free
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Product Specifications
Immunogen
Immunized with recombinant Human FGF acidic/FGF1 (Uniprot#: P05230; Met1-Asp155 (Uniprot#: P05230)
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Description
Novus Biologicals Mouse FGF acidic/FGF1 Antibody (C16) - BSA Free (NBP3-41078) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
Scientific Data Images for FGF acidic/FGF1 Antibody (C16) - BSA Free
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] -
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] - Sample: Lane1: Rat Cerebrum lysate; Lane2: Rat Heart lysate; Lane3: Mouse Heart lysate; Lane4: Mouse Kidney lysate; Lane5: Porcine Heart lysate Primary Ab: 0.8ug/ml NBP3-41078; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] -
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] - Sample: Lane1: Rat Cerebrum lysate; Lane2: Rat Heart lysate; Lane3: Mouse Heart lysate; Lane4: Mouse Kidney lysate; Lane5: Porcine Heart lysate Primary Ab: 0.8ug/ml NBP3-41078; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal AntibodyApplications for FGF acidic/FGF1 Antibody (C16) - BSA Free
Application
Recommended Usage
Western Blot
0.5-2ug/mL
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
0.01M PBS, pH7.4, 50% glycerol
Format
BSA Free
Preservative
0.05% Proclin 300
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: FGF acidic/FGF1
Long Name
Fibroblast Growth Factor acidic
Alternate Names
alpha-ECGF, beta-ECGF, FGF acidic, FGF-1, HBGF-1
Gene Symbol
FGF1
Additional FGF acidic/FGF1 Products
Product Documents for FGF acidic/FGF1 Antibody (C16) - BSA Free
Product Specific Notices for FGF acidic/FGF1 Antibody (C16) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Cellular Response to Hypoxia Protocols
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars
FAQs for FGF acidic/FGF1 Antibody (C16) - BSA Free
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A: These proteins are not assayed for their ability to bind Heparin. More information about the FGF family of growth factors is available in this review article: Basilico, C. (1992) Adv. Can. Res. 59:115.
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