Key Product Details

Species Reactivity

Mouse

Applications

Western Blot, Neutralization

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Polyclonal Sheep IgG
View all FGF acidic/FGF1 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant mouse FGF acidic/FGF1
Phe16-Asp155
Accession # NP_034327

Specificity

Detects mouse FGF acidic/FGF1 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human FGF acidic is observed, and less than 1% cross-reactivity with recombinant mouse (rm) FGF7, rmFGF21, and rmFGF23 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for FGF acidic/FGF1 Antibody [Allophycocyanin]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Neutralization

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FGF acidic/FGF1

FGF acidic/FGF1, also known as ECGF and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF1 can translocate to the cytosol and to the nucleus. Intracellular FGF1 functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.

Long Name

Fibroblast Growth Factor acidic

Alternate Names

alpha-ECGF, beta-ECGF, FGF acidic, FGF-1, HBGF-1

Gene Symbol

FGF1

Additional FGF acidic/FGF1 Products

Product Documents for FGF acidic/FGF1 Antibody [Allophycocyanin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for FGF acidic/FGF1 Antibody [Allophycocyanin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for FGF acidic/FGF1 Antibody [Allophycocyanin]

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    • A: These proteins are not assayed for their ability to bind Heparin. More information about the FGF family of growth factors is available in this review article: Basilico, C. (1992) Adv. Can. Res. 59:115.
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