Frizzled-8 Antibody (23GB5470)

Novus Biologicals | Catalog # NBP3-50408

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB5470
View all Frizzled-8 Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Frizzled-8 (Uniprot: Q9H461)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Frizzled-8 Antibody (23GB5470)

Frizzled-8 Antibody (23GB5470)

Flow Cytometry: Frizzled-8 Antibody (23GB5470)[NBP3-50408] -

Flow cytometric analysis of Frizzled-8expression in HepG2 cells using Frizzled-8 antibody (1:2,000). Green, isotype control; red, Frizzled class receptor 8.
Frizzled-8 Antibody (23GB5470)

Western Blot: Frizzled-8 Antibody (23GB5470)[NBP3-50408] -

Western blotting analysis using Frizzled-8 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Frizzled-8 Antibody (23GB5470)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Frizzled-8

"Frizzled-8 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Alternate Names

Frizzled8, FZD8

Gene Symbol

FZD8

Additional Frizzled-8 Products

Product Documents for Frizzled-8 Antibody (23GB5470)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Frizzled-8 Antibody (23GB5470)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Wnt Family
Wnt Receptors

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FAQs

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