Q: I am looking for a "Primary antibody for GABAa receptor gamma 2" raised from antigen whose aa sequence is between exon 5-10. The application will be for "Immunohistochemistry". I would like to know if you have a product to match it?

A: NB300-190 is direceted against GABA A receptor gamma 2, is suitable for use in IHC and uses a fusion protein from the cytoplasmic loop of the gamma 2 subunit as an antigen, so this should suit your needs.

GABA-A R gamma 2 Antibody

Novus Biologicals | Catalog # NBP1-49868

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Predicted:

Bovine (100%), Human (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all GABA-A R gamma 2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NNATHLQERDE corresponding to internal region according to NP_000807.2, NP_944493.2.

Epitope

NNATHLQERDE - internal region

Specificity

This antibody is expected to recognize all reported isoforms: NP_944494.1; NP_000807.2; NP_944493.2. Note the aa numbers used in the name are from NP_944494.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GABA-A R gamma 2 Antibody

Western Blot: GABA-A R gamma 2 Antibody [NBP1-49868]

Western Blot: GABA-A R gamma 2 Antibody [NBP1-49868] - Analysis of GABA -A Receptor gamma 2 in Mouse Brain lysate (35ug protein in RIPA buffer) using NBP1-49868 at 2 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for GABA-A R gamma 2 Antibody

Application

Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

1 - 3 ug/ml

Application Notes

WB: Approx. 50 kDa band observed in mouse and rat brain lysates (calculated MW of 55.1 kDa band according to mouse NP_032099.1 and 54.1 kDa band according to rat NP_899156.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R gamma 2

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.

Long Name

gamma-Aminobutyric Acid Type A Receptor, gamma-2 Polypeptide

Alternate Names

GABAAR gamma 2, GABAARg2, GABRG2

Entrez Gene IDs

2566 (Human); 14406 (Mouse); 29709 (Rat)

Gene Symbol

GABRG2

UniProt

NP_944494.1 (Human)

Additional GABA-A R gamma 2 Products

Product Documents for GABA-A R gamma 2 Antibody

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Certificate of Analysis

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Product Specific Notices for GABA-A R gamma 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

GABA Receptors

Citations for GABA-A R gamma 2 Antibody

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