Key Product Details

Species Reactivity

Human

Applications

Block/Neutralize, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG1 kappa Clone # hGR-2 F6

Format

Azide and BSA Free
View all Glucagon R/GCGR Primary Antibodies »

Product Specifications

Immunogen

Recombinant human Glucagon R/GCGR.

Specificity

The antibody binds to the human glucagon receptor, Glucagon R/GCGR.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free

Immunocytochemistry/ Immunofluorescence: Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free [NBP2-81065]

Immunocytochemistry/ Immunofluorescence: Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free [NBP2-81065]

Immunocytochemistry/Immunofluorescence: Glucagon R/GCGR Antibody (hGR-2 F6) [NBP2-81065] - Immunofluorescence staining of fixed HepG2 cells with [NBP2-81065]. Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells on Shi-fix coverslips, permeabilized with 0.15% Triton and stained with the chimeric mouse IgG1 version of hGR-2 F6 [NBP2-81065] at 10 ug/ml for 1h followed by Alexa Fluor 488 secondary antibody (2 ug/ml), showing punctate membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom NBP2-81065, DAPI, merged channels and an isotype control. The isotype control was stained with an unknown specificity antibody followed by Alexa Fluor 488 secondary antibody.

Applications for Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free

Application
Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody binds to the human glucaon receptor, a GPCR that is activated by glucagon and stimulates adenylate cyclase. The receptor is involved in glucose homeostasis and regulats glucose production in the liver. The antibody acts as a competitive antagonist.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Background: Glucagon R/GCGR

Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.

Long Name

Glucagon Receptor

Alternate Names

GCGR, GGR, GLR, GlucagonR

Gene Symbol

GCGR

Additional Glucagon R/GCGR Products

Product Documents for Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Glucagon R/GCGR Antibody (hGR-2 F6) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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