Granulin Antibody (CL5692) - Azide and BSA Free

Novus Biologicals | Catalog # NBP3-44043

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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL5692

Format

Azide and BSA Free
View all Granulin Primary Antibodies »

Product Specifications

Immunogen

This antibody was generated using a recombinant protein sequence of P28799, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Granulin Antibody (CL5692) - Azide and BSA Free

Granulin Antibody (CL5692) - Azide and BSA Free Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Staining of human kidney shows cytoplasmic immunoreactivity in both renal glomeruli and tubules.
Granulin Antibody (CL5692) - Azide and BSA Free Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Staining of human skeletal muscle shows absence of positivity in striated muscle fibers as expected (negative control).
Granulin Antibody (CL5692) - Azide and BSA Free Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Staining of human prostate shows moderate granular cytoplasmic immunoreactivity in glandular cells.
Granulin Antibody (CL5692) - Azide and BSA Free Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Immunohistochemistry-Paraffin: Granulin Antibody [NBP3-44043]

Staining of human small intestine shows moderate granular cytoplasmic positivity in glandular cells.

Applications for Granulin Antibody (CL5692) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS with Trehalose

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Alternate Names

acrogranin, GEP, GP88, granulin, granulin-epithelin, granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, progranulin

Gene Symbol

GRN

Additional Granulin Products

Product Documents for Granulin Antibody (CL5692) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for Granulin Antibody (CL5692) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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