Catalog Number: 4688
Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Biological Activity
Inactive control of GSK J1 (IC50 > 100 μM for inhibition of JMJD3/UTX).

Cell permeable ester derivative, GSK J5 and Active Analog also available.

Technical Data
  • M.Wt:
    389.45
  • Formula:
    C22H23N5O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1394854-52-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further details of GSK J2, an inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.
Other Product-Specific Information:
Background References
  1. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
    Kruidenier et al.
    Nature, 2012;488:404
Tocris Small Molecules
Description Application Cat# Citations Images  

GSK J1

4593 2  
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