Human 5-HT2C Alexa Fluor® 405-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB5764V-100UG
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Human 5-HT2C Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human 5HT2C in direct ELISAs.
Source
Monoclonal Mouse IgG2a Clone # 496214
Immunogen
NS0 mouse myeloma cell line transfected with human 5HT2C
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 405

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
A172 human glioblastoma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: 5-HT2C

5HT2C is a 45 kDa 7TM receptor for serotonin and is neuronally expressed in the limbic system of the brain. The release of dopamine due to 5HT2C ligation regulates mood, appetite, and motivation. 5HT2C is an important pharmacologic target in the treatment of psychosis, schizophrenia, depression, anxiety, and migrane headaches. Multiple isoforms of 5HT2C can be generated by RNA editing. Human 5HT2C shares 89% aa sequence identity with mouse and rat 5HT2C.

Long Name
5-Hydroxytryptamine Receptor 2C
Entrez Gene IDs
3358 (Human); 15560 (Mouse); 25187 (Rat)
Alternate Names
5-HT1C; 5-HT-1C; 5HT2C; 5-HT2C; 5-HT-2C; 5-HT2C5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine receptor 2C; HTR1C; HTR2C; serotonin 5-HT-2C receptor; Serotonin Receptor 2C

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