Human 5-HT2C PE-conjugated Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of 5‑HT2C in HEK293 Human Cell Line Transfected with Human 5-HT2C and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human 5-HT2C or (B) irrelevant protein, and eGFP was stained with Mouse Anti-Human 5‑HT2C PE‑conjugated Monoclonal Antibody (Catalog # FAB5764P) or (B) Mouse IgG2A PE Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
5-HT2C is a 45 kDa 7TM receptor that belongs to the G-protein coupled receptor #1 family. It binds serotonin and is neuronally expressed in the limbic system of the brain. The release of dopamine due to 5-HT2C ligation regulates mood, appetite, and motivation. 5-HT2C is an important pharmacologic target in the treatment of psychosis, schizophrenia, depression, anxiety, and migrane headaches. Multiple isoforms of 5-HT2C can be generated by RNA editing. Human 5-HT2C shares 89% aa sequence identity with mouse and rat 5-HT2C.
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