Human ACLP Alexa Fluor® 488-conjugated Antibody

    
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  • Species Reactivity
    Human
  • Specificity
    Detects human ACLP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse ACLP is observed.
  • Source
    Monoclonal Mouse IgG1 Clone # 590831
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human ACLP
    Glu345-Phe1158
    Accession # Q8IUX7
  • Formulation
    Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
  • Label
    Alexa Fluor 488
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Intracellular Staining by Flow Cytometry
    0.25-1 µg/106 cells
    HASMC human human aortic smooth muscle cells
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: ACLP

Aortic carboxypeptidase-like protein (ACLP), also known as adipocyte enhancer binding protein (AEBP1), is a 175 kDa molecule that contains a discoidin-like domain (aa 383-540) and a peptidase-like domain (aa 560-942). It is expressed in proliferating adipocytes and represses the transcription of FABP4. ACLP promotes macrophage cholesterol retention, the formation of foam cells, and inflammatory responses. It is also an extracellular matrix-associated protein found in fibrotic tissues including vascular smooth muscle. An alternately spliced isoform lacks aa 1-457 and has an altered sequence at its N-terminus. Over aa 345-1158, human ACLP shares 88% aa sequence identity with mouse and rat ACLP.

  • Long Name:
    Aortic Carboxypeptidase-like Protein
  • Entrez Gene IDs:
    165 (Human)
  • Alternate Names:
    ACLP; ACLPadipocyte enhancer binding protein 1; AE binding protein 1; AE-binding protein 1adipocyte enhancer-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612
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