Human alpha-Sarcoglycan Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: alpha-Sarcoglycan

Alpha-sarcoglycan is one of six known sarcoglycans, which are type I ( alpha - and epsilon -) or type II ( beta -, gamma -, δ- or zeta -) transmembrane glycoproteins. Sarcoglycans alpha and gamma are expressed exclusively in the sarcoplasmic reticulum in skeletal and cardiac muscle, while others are more widely expressed. Sarcoglycans form heterotetrameric, pentameric and hexameric membrane glycoprotein complexes (SGC). SGC interacts laterally with the dystroglycan complex, and both complexes are components of the dystrophin-associated glycoprotein complex (DGC), which forms a link between the cytoskeleton and the extracellular matrix. Mutations in sarcoglycans are associated with recessive autosomally inherited limb-girdle muscular dystrophy. Human alpha -sarcoglycan shares 90% amino acid sequence identity with mouse and rat alpha -sarcoglycan within the extracellular domain.

Product Datasheets

Related Research Areas

• Cardiac Stem Cell Markers
• Myogenesis Markers
• Proteoglycans
• Skeletal Muscle Markers