Human alpha-Sarcoglycan Antibody Summary
Accession # Q16586
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human alpha -Sarcoglycan by Western Blot. Western blot shows lysates of human skeletal muscle tissue and human heart tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human a-Sarcoglycan Monoclonal Antibody (Catalog # MAB7445) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for a-Sarcoglycan at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Alpha-sarcoglycan is one of six known sarcoglycans, which are type I ( alpha - and epsilon -) or type II ( beta -, gamma -, δ- or zeta -) transmembrane glycoproteins. Sarcoglycans alpha and gamma are expressed exclusively in the sarcoplasmic reticulum in skeletal and cardiac muscle, while others are more widely expressed. Sarcoglycans form heterotetrameric, pentameric and hexameric membrane glycoprotein complexes (SGC). SGC interacts laterally with the dystroglycan complex, and both complexes are components of the dystrophin-associated glycoprotein complex (DGC), which forms a link between the cytoskeleton and the extracellular matrix. Mutations in sarcoglycans are associated with recessive autosomally inherited limb-girdle muscular dystrophy. Human alpha -sarcoglycan shares 90% amino acid sequence identity with mouse and rat alpha -sarcoglycan within the extracellular domain.
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