Human ASAH2/N‑acylsphingosine Amidohydrolase‑2 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: ASAH2/N-acylsphingosine Amidohydrolase-2

The human ASAH2 gene encodes N-acylsphingosine amidohydrolase-2, also known as neutral or non-lysosomal ceramidase. ASAH2 is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein (1). The enzyme is abundant in the brush border membranes of the intestine, but is also expressed in tissues such as kidney, brain and liver (2, 3). An N-terminally truncated form of human ASAH2 has been shown to localize to mitochondria (4). A major physiological function of ASAH2 is the metabolism of dietary sphingolipids, but the enzyme may also be involved in the generation of messenger molecules such as sphingosine and sphingosine 1-phosphate (3).

Product Datasheets

Related Research Areas

• Bioactive Lipids and Receptors
• Lipid and Fatty Acid Transport
• Lipid/Cholesterol Metabolism Enzymes
• Steroid Hormones and Bioactive Lipids