Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

ELISA Development (Detection)

Label

Biotin

Antibody Source

Polyclonal Goat IgG
View all Carnosine Dipeptidase 1/CNDP1 Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Carnosine Dipeptidase 1/CNDP1
Pro28-His507
Accession # Q96KN2

Specificity

Detects human Carnosine Dipeptidase 1/CNDP1 in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody

Detection of Human Carnosine Dipeptidase 1/CNDP1 by ELISA

Detection of Human Carnosine Dipeptidase 1/CNDP1 by ELISA

Identification and validation of CNPD1 reduction in CC.Detected protein levels are shown for A. the screen using Sandwich Bead Arrays (SBA) and B. validation by Sandwich Immunoassays (SIA) and expressed as mean intensity fluorescence (MIF). C. There was an excellent correlation between results obtained by SBA and SIA. CNPD1 levels measured by SIA were not influenced by D. age or E. gender. F. Distribution of circulating CNDP1 concentrations determined by SIA in Cohort 2. WS = Weight stable, CC = Cancer cachexia. P- and rho-values are given. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0123566), licensed under a CC-BY license. Not internally tested by R&D Systems.

Applications for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Carnosine Dipeptidase 1/CNDP1 (Catalog # 2489-ZN)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Carnosine Dipeptidase 1/CNDP1

The human CNDP1 gene encodes carnosine dipeptidase 1, a member of the M20 family of metalloproteases (1, 2). Also known as X-His dipeptidase, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), CNDP1 is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa = beta -Ala (carnosine) and Xaa = gamma -aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter fucntions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase.

References

  1. Teufel, M. et al. (2004) J. Biol. Chem. 278:6521.
  2. Bauer, K. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) p. 1022, Academic Press, San Diego.

Alternate Names

Carnosinase 1, CNDP1, CPGL2

Entrez Gene IDs

84735 (Human)

Gene Symbol

CNDP1

UniProt

Q96KN2

Additional Carnosine Dipeptidase 1/CNDP1 Products

Product Documents for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody

For research use only

Related Research Areas

Metalloproteases and Regulators

Citations for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody

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