Human CCR6 Alexa Fluor® 594-conjugated Antibody
Human CCR6 Alexa Fluor® 594-conjugated Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of CCR6 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CCR6 Alexa Fluor® 594‑conjugated Monoclonal Antibody (Catalog # FAB195T) or (B) Mouse IgG2B Alexa Fluor 594 Isotype Control (Catalog # IC0041T). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 degreesC as supplied.
Human CCR6 (C-C Chemokine Receptor 6) is a 45-50 kDa member of the G-protein coupled receptor #1 family. It is a 374 amino acid (aa) 7-transmembrane glyocprotein that is responsive to a limited number of ligands, including CCL20/MIP-3 alpha and the beta -Defensins HBD-1 and -2. A large number of cell types express CCR6, which in human include neutrophils, spermatogonia, intestinal epithelial columnar cells, osteoblasts, IL-17 secreting CD161 + CCR6 + TCR-V alpha 7.2 CD8 + Tcells, monocytes, macrophages, CD4 + CCR4 + CXCR3 - CCR6 + IL-17 secreting Th17 cells, CD4 + CCR4 - CXCR3 + CCR6 + IL-17 secreting and IFN-gamma secreting Th1 Th17 cells and hepatic carcinoma plus colon carcinoma cells. On mouse cells, CCR6 is found on CD4 + CD25 + CD45RO + memory Tregs, CD4 - CD8 - CD25 - CD44 + c-Kit + CCR6 + double-negative thymocytes, and CD116 + CCR6 + dendritic cells plus CD11c + B220 + CD19 + IgM + CCR6 + Peyer's Patch B cells. CCR6 activity may be cell or environment specific, and actions described to date include the promotion of cell proliferation, the downregulation of IL-12 production, and chemotaxis. The extracellular domains of human and mouse CCR6 share 52% aa sequence identity.
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