Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Product Details

Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: CD1c/BDCA-1

Cluster of Differentiation Antigen 1c/Blood Dendritic Cell Antigen 1 (CD1c/BDCA-1) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by humans but not by mice or rats. Human CD1c/BDCA-1 is a 316 amino acid protein with a predicted molecular weight of 43 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. CD1c/BDCA-1 is expressed by dendritic cells and B cells, where it traffics between endosomes and the plasma membrane. Heterodimerization with beta-2-Microglobulin is required for CD1c membrane trafficking. CD1c is thought to present a wide variety of lipids to T cells and has been shown to mediate T cell activation in response to Mycobacterium tuberculosis.

Entrez Gene IDs
911 (Human)
Alternate Names
BDCA1; BDCA-1; c polypeptide; CD1; CD1A; CD1c antigen; CD1c molecule; CD1c; cortical thymocyte antigen CD1C; differentiation antigen CD1-alpha-3; R7; T-cell surface glycoprotein CD1c


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