Cluster of Differentiation Antigen 1c/Blood Dendritic Cell Antigen 1 (CD1c/BDCA-1) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by humans but not by mice or rats. Human CD1c/BDCA-1 is a 316 amino acid protein with a predicted molecular weight of 43 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. CD1c/BDCA-1 is expressed by dendritic cells and B cells, where it traffics between endosomes and the plasma membrane. Heterodimerization with beta-2-Microglobulin is required for CD1c membrane trafficking. CD1c is thought to present a wide variety of lipids to T cells and has been shown to mediate T cell activation in response to Mycobacterium tuberculosis.
Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
R&D Systems | Catalog # RDC1272
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CD1c/BDCA-1
Additional CD1c/BDCA-1 Products
Product Documents for Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
For research use only
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